EUROPEAN NETWORK OF BREAST DEVELOPMENT AND CANCER LABS
Login to enter/edit your group information
LIST OF EUROPEAN LABS WORKING IN THIS RESEARCH AREA:
=> Search labs by keyword(s):    
Last name ACETO
First name NICOLA
Institution University of Basel
Country SWITZERLAND
Phone +41-61-207-0773
E-mail Nicola.Aceto@unibas.ch
Website http://www.cancermetastasislab.com/
Group leader since (year) 2015
Research interests Circulating tumor cells, metastasis, features of metastatic cells, patient samples, mouse models, single cell-resolution next-gen sequencing, microfluidics, molecular and computational biology
Models Patient samples, ex-vivo culture of human circulating tumor cells, patient-derived xenografts, genetically-engineered mouse models
Methods Single cell sequencing, microfluidics, molecular and computational biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Saturday, December 10, 2016
 
Last name ALEXANDER
First name CAROLINE
Institution University of Wisconsin-Madison
Country UNITED STATES
Phone 608-265 5182
E-mail alexander@oncology.wisc.edu
Website http://mcardle.oncology.wisc.edu/faculty/bio/alexander_c.html
Group leader since (year) 2000
Research interests Mammary gland development; mouse models; Wnt signaling; paracrine interactions; triple negative tumors; mammary stem cells; post-transcriptional regulation; Lrp5
Models Mouse breast cancer models; development of mouse mammary gland; murine breast cell culture lines
Methods mammary stem cell assays; genetic manipulation of culture models, including primary mouse mammary epithelial cells; micro channel cultures; standard molecular biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, February 18, 2014
 
Last name ALLEGRUCCI
First name CINZIA
Institution SVMS and Centre for Genetics and Genomics, University of Nottingham
Country UNITED KINGDOM
Phone +44 (0)1159516487
E-mail cinzia.allegrucci@nottingham.ac.uk
Website http://beta.nottingham.ac.uk/Genetics/Research/staff.aspx
Group leader since (year) 2009
Research interests Breast cancer, cancer stem cells, epigenetics, developmental biology, expression profiles, molecular oncology, triple negative breast cancer, autoimmunity, cancer reprogramming
Models 3D matrigel, cell lines, xenografts
Methods Microarrays,next generation sequencing, chromatin immunoprecipitation, flowcytometry, retro-lentivirus transgenesis
List of transgenic and KO
mice available
No
Comments
(including wish list)
None
Last update
Friday, May 10, 2013
 
Last name ANDRECHEK
First name ERAN
Institution Michigan State University
Country UNITED STATES
Phone 517-884-5042
E-mail andrech1@msu.edu
Website https://www.msu.edu/~andrech1/
Group leader since (year) 2009
Research interests Bioinformatics, gene expression analysis, predictive signatures, mammary development, breast cancer, transgenics, knockouts, HER2/Neu, Myc, PyMT
Models MMTV-Myc, MMTV-Neu, MMTV-PyMT, E2F knockout mice
Methods We seek to integrate bioinformatics with breast biology. We predict the roles of key cell signaling pathways with signatures and gene expression data in mammary gland development and then test these predictions using mouse model systems.
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Wednesday, June 13, 2012
 
Last name ARRIBAS
First name JOAQUIN
Institution Vall d'Hebron Institute of Oncology (VHIO) and CIBERONC
Country SPAIN
Phone +34 93 254 3450
E-mail jarribas@vhio.net
Website www.vhio.net
Group leader since (year) 1997
Research interests cellular senescence, intracellular signaling pathways, tumor immunology, anti-HER2 therapies
Models Breast cancer PDXs (more than 30) in immunodeficient and humanized models
Methods PDXs, 3D cultures
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, March 15, 2017
 
Last name BARASH
First name ITAMAR
Institution ARO, The Volcani Center
Country ISRAEL
Phone +972-8-9484418
E-mail itamar.barash@mail.huji.ac.il
Website http;//www.agri.gov.il/en/people/619.aspx
Group leader since (year) 1990
Research interests mammary gland; Stat5; mammary stem cells; translation regulation, mTOR and amino acids as a signale molecules
Models Transgenic and conditional activation/ repression of Stat5 expression in the mammary gland
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, May 1, 2014
 
Last name BENTIRES-ALJ
First name MOHAMED
Institution Department of Biomedicine University of Basel / University Hospital Basel
Country SWITZERLAND
Phone +41 (0)61 26 52 945
E-mail m.bentires-alj@unibas.ch
Website https://biomedizin.unibas.ch/research/research-group-details/home/rese...
Group leader since (year) 2006
Research interests Breast Tumor Heterogeneity, Metastasis and Resistance (cell and non-cell autonomous mechanisms). Personalised breast cancer therapy
Models 3D cultures, ex vivo culture models (HMECs...), xenograft, KO and transgenic mice, humanised mouse models
Methods Multiphoton intravital imaging, CRISPR and transposon-based screens, lineage tracing, PDX
List of transgenic and KO
mice available
No
Comments
(including wish list)
none
Last update
Friday, January 12, 2018
 
Last name BIRNBAUM
First name DANIEL
Institution Centre de Recherche en Cancérologie de Marseille, UMR599 Inserm and Institut Paoli-Calmettes
Country
Phone 33 4 91 75 84 07
E-mail daniel.birnbaum@inserm.fr
Website http://crcm-en.marseille.inserm.fr/
Group leader since (year) 1987
Research interests Molecular Oncology, Oncogenomics, Breast cancer, Leukemia, Colon cancer, Tyrosine kinases, Oncogenes, Prognosis markers, Mitosis, Centrosome.
Models Human pathologies, cell lines, mouse models.
Methods DNA microarrays, array-CGH, FISH, sequencing, tissue microarrays, videomicroscopy, confocal microscopy, transgenesis, xenografts.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, February 19, 2015
 
Last name BLAAS
First name LEANDER
Institution Karolinska Institutet
Country SWEDEN
Phone
E-mail leander.blaas@ki.se
Website http://ki.se/en/bionut/startpage
Group leader since (year)
Research interests Mammary gland development, breast cancer heterogeneity, tumor cells-of-origin
Models 3D cultures (primary human cells), mouse models, xenografts,
Methods Confocal microscopy, CRISPR/Cas9, FACS, lineage tracing
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, May 2, 2018
 
Last name BONIZZI
First name GIUSEPPINA (GIUSY)
Institution European oncology institute (IEO)
Country
Phone +390257489396
E-mail giuseppina.bonizzi@ifom-ieo-campus.it
Website
Group leader since (year)
Research interests Breast Stem cell and Breast cancer stem cell
Models 3D cultures, xenograft, KO and transgenic mice, humanized mouse
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
none
Last update
Monday, August 25, 2008
 
Last name BØRRESEN-DALE
First name ANNE-LISE
Institution Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
Country
Phone +47 22 78 13 73
E-mail a.l.borresen-dale@medisin.uio.no
Website http://www.radium.no/genetics/
Group leader since (year) >20 years
Research interests The Department's Research vision is exploring The Systems Biology of Breast Cancer Our research program is focusing on the molecular biology of breast and ovarian cancer with emphasis on identification of genotypes and gene expression profiles contributing to elevated cancer risk, radiation sensitivity, tumor aggressiveness and therapy resistance. The hypothesis is that both the geno- and phenotype of the tumor as well as the patients own genotype (the genetic “makeup” of the patient constituted by both high and low penetrance genes) play a role in breast and ovarian cancer risk, in the type of cancer developed, the disease course and the response to treatment. The results may be used to identify high-risk individuals that may benefit from preventing strategies, and to individualize the treatment of patients with respect to choice of drugs as well as to dose and duration. This may give a better therapeutic effect and less adverse reactions in the individual patient. Goals: 1. To join forces and expertise to create a world-leading Breast Cancer Research Center including The Dept of Medical Statistic Faculty of Medicine, Dept of Informatics, Faculty of Mathematics and Natural Sciences, UiO, The Norwegian Radium Hospital, Ullevål Univ. Hospital and potentially other hospitals in the Oslo area 2. To follow the linear time course of predisposition, initiation, early stages and advanced disease and to dissect the molecular mechanisms triggered at each stage 3. To follow the multidimentional interactions at various levels in a systems biology approach
Models large cohorts of breast cancer patients with long term follow up, and healty woman participating in a population based study NOWAC http://uit.no/kk/NOWAC/
Methods large scale analyses using various array technology to perform WGA on SNPs and CNVc, blood expression (mRNA and miRNA), Tumor mRNA and miRNA expression, aCGH, mutation, methylation and protein anaalyses using RPPA
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, July 20, 2010
 
Last name BRACKE
First name MARC
Institution Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Country
Phone +32 9 332 3007
E-mail brackemarc@hotmail.com
Website http://www.ugent.be/people?ugentid=801000436153
Group leader since (year) 2003
Research interests Mechanisms of tumor invasion and metastasis, mammary cancer, stromal interactions with cancer cells (myofibroblasts, adipocytes and stem cells), cytoskeleton and motility, cadherin/catenin complexes in cell-cell adhesion, endoplasmic reticulum stress, radiation-induced effects on invasion, new circulating tumor markers, invasion suppressor genes, early metastasis genes, hormones and breast cancer.
Models 3D-models for invasion in vitro (embryonic chick heart, type I collagen, Matrigel, reconstituted tissues), metastasis models in laboratory mice, aggregation models for cell-cell adhesion, interaction models between stromal and cancer cells, directional migration models (wound healing, checker board analysis, radial aggregate outgrowth).
Methods Organotypic confronting cultures for invasion, Western blot, immunoprecipitation, transfection, siRNA, time-lapse microscopy, immunohisto/cytochemistry, raising monoclonal antibodies, ELISA, assays for ER stress and apoptosis, cell irradiation, PCR…
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name BRACKENBURY
First name WILLIAM
Institution University of York
Country UNITED KINGDOM
Phone +44 (0)1904 328284
E-mail william.brackenbury@york.ac.uk
Website http://www.york.ac.uk/biology/research/molecular-cellular-medicine/wil...
Group leader since (year) 2011
Research interests Breast cancer, voltage-gated sodium channels, cell migration, adhesion, metastasis
Models Cell lines, xenografts, tumour samples
Methods Adhesion and migration assays, confocal microscopy, protein biochemistry, electrophysiology, pharmacology, realtime PCR, in vivo imaging.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, December 2, 2011
 
Last name BRAGA
First name VANIA
Institution Molecular Medicine, NHLI, Faculty of Medicine Imperial College London
Country
Phone +44 20 7594-3233
E-mail v.braga@imperial.ac.uk
Website
Group leader since (year) 1996
Research interests epithelial polarization and differentiation, signalling from cell-cell adhesion receptors, small GTPases, cell-cell adhesion, cadherin receptors, morphological transformation, cancer cell biology
Models primary cultures of keratinocytes, cell lines
Methods microinjection, microscopy, RNAi, RNAi screen, protein-protein interaction, cell-cell adhesion assays, yeast two-hybrid, Q-PCR. intracellular trafficking assays
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name BRISKEN
First name CATHRIN
Institution Swiss Institute for Experimental Cancer Research (ISREC) School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL)
Country SWITZERLAND
Phone 41-21-6925851
E-mail cathrin.brisken@epfl.ch
Website http://www.nccr-oncology.ch/scripts/index.aspx?idd=85
Group leader since (year) 2001
Research interests Mammary gland development, breast cancer, hormone action, intercellular communication, morphogenesis
Models mouse mutant strains, primary human breast epithelial cells
Methods tissue recombinations techniques, primary cultures of mouse and human breast epithelial cells, retro and lentiviral infections
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Sunday, January 11, 2009
 
Last name BUSTELO
First name XOSE
Institution Salamanca Cancer Research Center / Centro de Investigacion del Cancer de Salamanca
Country SPAIN
Phone +34 923 29 4802
E-mail xbustelo@usal.es
Website http://www.cicancer.org/vergrupo.php?IdGrupo=3
Group leader since (year) 2006
Research interests Our research is focused on the functional characterization of signal transduction molecules with oncogenic potential and, particularly, on the functional analysis of oncoproteins specialized in connecting the stimulation of membrane receptors with signaling routes that lead to both cytoskeletal change and mitogenic processes. Within this general objetive, the current research of our laboratory is aimed at solving the following biological issues: (1) Functional characterization of the Vav oncoprotein family, a group of signal transduction molecules that work as phosphorylation-dependent GDP/GTP exchange factors for the GTPases of the Rho/Rac family. (2) Functional analysis of specific members of Rho/Rac family of GTPases. (3)Characterization of intracellular positive and negative regulators of Rho/Rac GTPases. (4) Study of the cross-talk between cytoskeletal routes and other biological processes. (5) Characterization of the role of these signaling routes in cancer, paying attention to both intrinsic (proliferation, survival, metastasis) and extrinsic (angiogenesis, inflammatory response) pathways that affect the final fitness of tumors in vivo. (6) Characterization of the role of these signal transduction pathways in other high incidence health problems such as cardiovascular disease and the metabolic syndrome. (7) Development of new therapeutic avenues to treat those diseases using molecular targets belonging to those signaling routes. To achieve these aims, our laboratory utilizes a quite diverse collection of experimental tools, including biochemical analysis (i.e., determination of enzyme activities, post-translational modifications, protein-protein interactions), structural biology (i.e., determination of the three-dimensional structure of proteins), cell biology, cell signaling (i.e., characterization of the signaling routes used by the oncoproteins under study) transgenic and knockout mice, genetic models available in invertebrate species (Drosophila, yeast) as well as genomics, proteomics, and cellomics techniques.
Models Human pathologies, cell lines, knockout and knock-in mouse models.
Methods Signal transduction, cytoskeleton, DNA microarrays, proteomics, videomicroscopy, confocal microscopy, cell lines, primary epithelial cells, epithelial tumor biology, cardiovascular techniques, xenograft, KO and transgenic mice
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, May 2, 2013
 
Last name CALDAS
First name CARLOS
Institution Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge
Country
Phone +44(0)1223 404420
E-mail cc234@cam.ac.uk
Website http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/caldasc/...
Group leader since (year) 1997
Research interests Breast cancer Genomics Cancer stem cells microRNA Oncogenes and tumor supressor genes 8p12
Models Cell lines Human breast cancers Mouse models
Methods Expression microarrays Array-CGH Bioinformatics Tissue microarrays Xenografts Mammosphere assay
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name CELIÀ-TERRASSA
First name TONI
Institution Hospital del Mar Medical Research Institute (IMIM); PRBB
Country SPAIN
Phone +34 93 316 04 34
E-mail acelia@imim.es
Website https://www.imim.cat/programesrecerca/cancer/laboratori_celia/en_index...
Group leader since (year) 2018
Research interests Breast cancer metastasis; Mammary gland stem cells (MaSCs); Cancer stem cells (CSCs); Tumor immunity; Epithelial-to-mesenchymal transition; Cell plasticity; Metastatic Niche
Models Genetically engineered mouse models; Isogenic metastatic cell lines; primary MaSCs and CSCs; Patient-derived Xenografts.
Methods 3D cultures; 3D imaging; Transcriptomics; In vivo metastasis assays; Mammary galnd regeneration assays; Lineage-tracing
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, November 7, 2018
 
Last name CHARIOT
First name ALAIN
Institution Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry Unit, University of Liege, Belgium
Country
Phone 32 4 366 24 72
E-mail alain.chariot@ulg.ac.be
Website http://www.chimmed.ulg.ac.be
Group leader since (year) 2005
Research interests Insight into the NF-kB and IRF-activating signaling pathways: Elucidation of the TBK1/IKKe-dependent cascades in vivo. Insight into their deregulations in breast cancer.
Models We are currently generating a transgenic model for IKKe
Methods Yeast-two hybrid, micro-array analyses, ChIP assays, kinase assays, IPs, Real-time PCRs.
List of transgenic and KO
mice available
No
Comments
(including wish list)
We are interested in exploring the oncogenic potential of two kinases, TBK1 and IKKe, by extending our knowledge from the molecular level to an in vivo model.
Last update
Monday, September 29, 2008
 
Last name CHEN
First name XI
Institution Baylor College of Medicine
Country UNITED STATES
Phone 1-713-798-4398
E-mail xc2@bcm.edu
Website https://www.bcm.edu/people/view/xi-chen-ph-d/4f284b32-3851-11e4-a42d-0...
Group leader since (year) 2015
Research interests Endoplasmic Reticulum Stress; Unfolded Protein Response; Tumor microenvironment; Breast cancer progression and metastasis; Tumor immunology
Models Genetically engineered mouse models; patient derived xenografts; Cancer cell lines.
Methods Orthotopic transplantation; tail vein injection; biochemistry, genomics, proteomics, FACS, CRISPR/Cas9.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, December 16, 2016
 
Last name CINTI
First name SAVERIO
Institution Dept. of Experimental and Clinical Medicine, School of Medicine, University of Ancona (Politecnica delle Marche), Ancona, Italy
Country
Phone +39 0712206088
E-mail cinti@univpm.it
Website http://www.univpm.it/Entra/Engine/RAServePG.php/P/320710012049/idsel/3...
Group leader since (year) 1984
Research interests Adipose organ. Adipose tissue of the mammary gland. Interaction between epithelial cells in mammary gland and adipocytes. White adipose tissue. Brown adipose tissue. Transdifferentiation.
Models Murine, human biopsies
Methods Lineage tracing. Light microscopy. Immunohistochemistry. Immunocytochemistry. Confocal microscopy. Electron microscopy. LacZ and GFP mice. Morphometry. Micro-dissection. Whole mount tissue embedding, adipose cell culture
List of transgenic and KO
mice available
No
Comments
(including wish list)
Our data obteined with several techniques including two models of lineage tracing, support the reversible transdifferentiation of milk secretory epithelial cells (PINK ADIPOCYTES see Cinti S Trends In Endocrinology and Metabolism, 2018 and Diabetes, Type2 Diabetes and The Adipose Organ (book), Springer 2018) into adipocytes in the mammary gland. PNAS, 101, 48, 16801-16806, 2004; These phenomena are supported also by explants experiments of both fat and isolated mature adipocytes (In vivo physiological transdifferentiation of adult adipose cells, De Matteis R et al. Stem Cells. 2009 Nov;27(11):2761-8. We showed that Osteopontin and ELF5 are candidate molecules to drive WHITE-PINK transdifferentiation (Prokesch A et al Stem Cells. 2014 Oct;32(10):2756-66 ).
Last update
Sunday, December 2, 2018
 
Last name CLARKE
First name ROB
Institution University of Manchester
Country
Phone 44-(0)161-306 0802
E-mail robert.clarke@manchester.ac.uk
Website http://www.breastcentre.manchester.ac.uk/
Group leader since (year) 2003
Research interests Human breast development, breast cancer metastasis, steroid receptors, signalling and stem cells
Models Primary human breast tissue xenografts and 3D breast cell culture: matrigel and mammospheres
Methods PDX models, assays for stem cell activity, single cell analysis and 'omics.
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Breast cancer PDX models
Last update
Monday, December 3, 2018
 
Last name CLARKSON
First name RICHARD
Institution University of Cardiff School of Biosciences
Country
Phone +2920 870249
E-mail clarksonr@cf.ac.uk
Website http://www.cardiff.ac.uk/biosi/research/genetics/index.html
Group leader since (year) 2005
Research interests involution, apoptosis, programmed cell death, transcription factors, signaling, development, cancer
Models mouse and human, normal and cancer cell lines mouse primary cell culture conditional KO and conditional transgenics mouse transgenic models of BC
Methods chIP, microarrays, MRI, transgenesis, QPCR, immunodetection
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name COOMBES
First name R CHARLES
Institution Imperial College
Country
Phone 020 8383 5828
E-mail c.coombes@imperial.ac.uk
Website http://www.imperial.ac.uk/medicine/sora
Group leader since (year) 20+
Research interests I run a laboratory of approximately 200 staff in which we are engaged in the development of new forms of treatment for breast cancer, particularly endocrine therapy. Over the past 20 years, my group has completed the clinical development of two steroidal aromatase inhibitors, including 4-hydroxyandrostenedione and exemestane and my laboratory is currently engaged in studies aimed at understanding the role of estrogen receptor a and estrogen receptor ß in human breast cancer. We are engaged in developing novel methods for prediction of response to endocrine therapy and also doing research aimed at understanding the mechanisms of resistance to endocrine therapy.
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name COWIN
First name PAM
Institution NYUSOM
Country UNITED STATES
Phone 2122638715
E-mail cowinp01@nyumc.org
Website
Group leader since (year) 1987
Research interests beta-catenin, Hedgehog and GPCR signaling in embryonic and adult mammary development and cancer
Models MMTV-deltaN87-beta-catenin
Methods in vivo and in vitro analysis of stem cell, cancer stem cell and niche requirements utilizing murine breast cancer and Wnt/Hedgehog reporter mice
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, May 6, 2013
 
Last name DAIDONE
First name MARIA GRAZIA
Institution Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (MI)
Country ITALY
Phone +39-02-2390-2238
E-mail MariaGrazia.Daidone@istitutotumori.mi.it
Website http://www.istitutotumori.mi.it/
Group leader since (year) 1997
Research interests Identification and characterization of human breast cancer-initiating cells (BCICs) using different approaches.In vitro models to investigate novel therapies targeting BCICs. Gene expression profiling to identify prognostic and treatment-predictive signatures in breast tumors. Isolation and molecular characterization of circulating tumor cells. microRNA profiling of breast tumors stroma and plasma: associated with tumor progression.
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Saturday, March 26, 2011
 
Last name DALE
First name TREVOR
Institution Cardiff University
Country
Phone +44 29 2087 4652
E-mail daletc@cardiff.ac.uk
Website http://www.cardiff.ac.uk/biosi/contactsandpeople/stafflist/a-d/dale-tr...
Group leader since (year) 1992
Research interests Wnt signalling, stem cells, drug discovery, biochemistry of Wnt signalling protein complexes, signalling pathway networks.
Models gene targetted mice (knock-out and transgenic) for components of the Wnt pathway. GFP and luciferase reporter readouts for Wnt pathway activity. We have developed new in vitro organoid culture models for the normal and transformed mammary epithelium.
Methods ES cell technologies, fat pad transplantation, protein biochemistry, high content screening
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
We have tetracycline-inducible mouse models that allow induction of Wnt pathway activators and repressors in the mammary gland. We also have conditional alleles of Axin1 and Axin2.
Last update
Wednesday, May 1, 2013
 
Last name DERKSEN
First name PATRICK
Institution University Medical Center Utrecht / Pathology
Country
Phone +31 88 75 68068
E-mail pderksen@umcutrecht.nl
Website http://www.umcutrecht.nl/subsite/oncology/Research-groups/Derksen
Group leader since (year) 2007
Research interests Mouse Models; Mammary gland development and cancer; Metastasis
Models Human ILC and IDC cell lines; Conditional Mouse Models of ILC
Methods Orthotopic transplantations; lentiviral transductions; In vivo imaging
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Saturday, December 1, 2012
 
Last name DEVINOY
First name EVE
Institution Institut National de la Recherche Agronomique (INRA)
Country
Phone +33 (0) 134652921
E-mail eve.devinoy@jouy.inra.fr
Website http://w3.jouy.inra.fr/unites/gpl/index.shtml
Group leader since (year)
Research interests The unit works on genomics and physiology of lactation: hormonal signalisation, gene expression control, synthesis of milk components, membrane traffic, endo/exocytosis pathways.
Models Rabbit, cattle and mouse mammary gland tissue.
Methods Cryosections of mammary tissue for DNA, RNA FISH, IF. Preservation of nuclear structure, confocal microscopy, 3D reconstitution and modelling
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, December 18, 2012
 
Last name DI FIORE
First name PIER PAOLO
Institution Istituto Europeo di Oncologia, via Ripamonti 435, 20141 Milan (Italy) and FIRC Institute of Molecular Oncology (IFOM) Foundation, Via Adamello 16, Milano, Italy
Country
Phone +39 2 94375198
E-mail pierpaolo.difiore@ieo.eu
Website http://www.ifom-ieo-campus.it/ and http://www.ifom.eu/it/
Group leader since (year) 1987
Research interests 1. Transformation by growth factor and growth factor receptor molecules as a tool to study the normal pathways regulating cell growth and their alteration in the neoplastic process. 2.Mechanisms of mitogenic signal transduction and attenuation by growth factor receptors under normal and neoplastic conditions.3. Breast stem cell biology
Models
Methods DNA microarrays, tissue microarrays, primary cell culture, 3D breast cell culture, protein biochemistry,
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, November 8, 2018
 
Last name DONTU
First name GABRIELA
Institution King's College iLondon
Country UNITED KINGDOM
Phone 44(0)2071883027
E-mail gabriela.dontu@kcl.ac.uk
Website
Group leader since (year) 2009
Research interests mammary stem cells normal breast development breast cancer stem cells
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, May 13, 2009
 
Last name EDWARDS
First name PAUL
Institution Department of Pathology and Cancer research UK Cambridge Institute, University of Cambridge
Country
Phone
E-mail pawe1@cam.ac.uk
Website http://www.path.cam.ac.uk/directory/paul-edwards and pawefish.path.cam...
Group leader since (year) 1977
Research interests Genomics of breast cancer, particularly genome rearrangements and mobile elements. Previous interest was development of normal and neoplastic mammary gland
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Retired 2016 but still active.
Last update
Thursday, December 1, 2016
 
Last name ELIAS
First name SALAH
Institution University of Southampton
Country UNITED KINGDOM
Phone +44(0)23 8059 2985
E-mail S.K.Elias@soton.ac.uk
Website https://www.southampton.ac.uk/biosci/about/staff/ske1r17.page
Group leader since (year) 2017
Research interests We are interested in studying the mechanisms that dictate fate choices in mammary stem cells during epithelial morphogenesis, homeostasis and transformation.
Models Transgenic mouse models and 3D organoids
Methods Lineage tracing; Gene invalidation strategies; whole mount confocal imaging; light-sheet imaging; live imaging; mathematical and computational modelling; proteomics; transcriptomics; Crispr/Cas9; FACS.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, May 4, 2018
 
Last name FARNIE
First name GILLIAN
Institution University of Oxford
Country UNITED KINGDOM
Phone 01865 227377
E-mail gillian.farnie@sgc.ox.ac.uk
Website http://www.thesgc.org/node/15362 https://www.ndorms.ox.ac.uk/team/gill...
Group leader since (year) 2008
Research interests DCIS, 3D models, Cancer stem cells and therapy resistance.
Models
Methods Ppatient derived sample in vitro and in vivo culture. CSC assay, FACS, mammospheres, limiting dilution in vivo. 3D hydrogel models.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, May 29, 2018
 
Last name FERBY
First name INGVAR
Institution Ludwig Institute for Cancer Research Ltd
Country
Phone +46 18 160403
E-mail ingvar.ferby@licr.uu.se
Website http://www.licr.uu.se/D_groups/d4_Signaling-Dynamics.php
Group leader since (year) 2006
Research interests Spatiotemporal control of ErbB receptor signalling in mammary gland development and carcinogenesis
Models Knockout and transgenic mouse models.
Methods General molecular cell biology, protein biochemistry and primary cell culture.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, February 22, 2013
 
Last name FLINT
First name DAVID
Institution Strathclyde University
Country
Phone +44 141 548 2693
E-mail david.flint@strath.ac.uk
Website http://www.strath.ac.uk
Group leader since (year) 20+
Research interests insulin-like growth factors, EMT
Models 3D co-culture approaches
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, August 25, 2008
 
Last name FRE
First name SILVIA
Institution Institut Curie
Country FRANCE
Phone +33156246936
E-mail silvia.fre@curie.fr
Website http://ugbdd.curie.fr/en/article/001055-notch-signaling-stem-cells-and...
Group leader since (year) 2013
Research interests Stem Cells, Lineage Specification, Notch signaling, intestine, mammary gland, breast cancer, colon cancer, tissue morphogenesis,
Models Mouse
Methods lineage tracing, transgenic mice, organotypic cultures, FACS, mammary fat pad transplantations, RNAseq, single cell analysis
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, September 9, 2015
 
Last name GALLAGHER
First name WILLIAM
Institution UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Country
Phone +353-1-7166743
E-mail william.gallagher@ucd.ie
Website http://www.ucd.ie/conway/cv_188.html
Group leader since (year) 1999
Research interests (1) Systematic approaches to cancer biology, (2) Molecular basis of tumour progression, particularly metastasis, (3) Cancer biomarker discovery/validation, (4) Breast cancer and melanoma
Models Isogenic cell culture models, in vivo models, particularly xenograft (syngenic/orthotopic)
Methods Transcriptomics, proteomics, tissue microarrays, RNA interference, lentiviral transduction, non-invasive in vivo imaging (bioluminescence/biofluorescence, PET/CT)
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name GASCÓN
First name PERE
Institution IDIBAPS-Hospital Clinic, Barcelona
Country SPAIN
Phone +34932275400 ext.5402
E-mail gascon@clinic.ub.es; ametller@clinic.ub.es; gfuster@clinic.ub.es
Website
Group leader since (year) 2004
Research interests The Laboratory of Molecular and Translational Oncology is a research group established in 2004 by Dr. Pere Gascon to study the relationship between neuropeptides, in particular the tachykinins and tumoral progression as well as mechanisms of metastasis in breast cancer (research funded by the Instituto de Salud Carlos III- FISS 041353, FISS PI080022, FISS PI12/01706). It is noteworthy that from these studies a patent was also created --PCT/ES2009/00019; EUROPE (USA pending) --. New lines of interest have been implemented since then; indeed a new research line based on the origin of tumor heterogeneity in breast cancer has been recently started in the lab. This research line began as a result of the confluence of the studies performed by Dra. Vanessa Almendro during her long stage in the laboratory of Dr. Kornellia Polyak in the Dana Farber Cancer Institute (Harvard Medical School, Boston, US)(2008-2013) and Dr. Pere Gascón previous research, focused in the role of the microenvironment in tumor progression and metastasis. At present, the study of chemoresistance mechanisms is also an active area of research, as evidenced by the related publications of the last years, and a new project aimed to study the epigenetic mechanisms involved in acquired chemoresistance is currently undergoing (funded by FISS PI11/01234) in the lab.
Models
Methods In vitro and in vivo models related to breast cancer and colon cancer. Primary cultures (fibroblasts and epithelial cells)
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, February 19, 2015
 
Last name GEE
First name JULIA
Institution Breast Cancer (Molecular Pharmacology) Group, School of Pharmacy & Pharmacuetical Sciences, Cardiff University, Cardiff CF10 3NB, United Kingdom
Country
Phone +44 29 20874922
E-mail gee@cardiff.ac.uk
Website http://www.cf.ac.uk/phrmy/researchcentres/BCMPG/index.html
Group leader since (year) 2000
Research interests Historically our group (previously Tenovus Centre for Cancer Research) has undertaken research in the area of anti-hormone and anti-growth factor resistance in breast cancer through signal transduction/pharmacological challenge studies. Two of our key current research interests are (i) exploring very early anti-hormone-induced "compensatory" signal transduction that limits initial response, promotes cell survival and facilitates evolution of resistance and further features of progression (e.g. invasion). (ii) modelling and deciphering of signalling pathways altered as a consequence of long-term (>3yr) adjuvant antihormone exposure (versus initial acquired resistance). A pervading goal in all our studies is to reveal new therapeutic targets to subvert resistance/progression and improve response, as well as providing new markers of therapeutic response & prognosis.
Models In house panel of in vitro models derived from anti-hormone responsive ER+ HER2- and ER+ HER2+ breast cancer cells to reflect acquired resistance to various antihormones and erbB inhibitors, such as herceptin. Our recent studies extend into 3D cell culture.
Methods Cell culture and signal transduction methodologies (including Western Blotting/PCR/reporter gene construct assays, pharmacological/antibody challenge) are core for candidate pathway studies as applied to our breast cancer models. My own areas of expertise lie in immunocytochemistry, notably using phosphospecific antibodies and their application to clinical material. I have also recently coordinated Affymetrix microarray studies as applied to our panel of cell lines that are revealing novel signalling elements induced during early drug treatment or elevated in established resistance. The relevance of these changes is subsequently being explored through functional studies, including employing SiRNA knockdown.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Some of our cell lines are available for collaborative studies under MTA, and our Affymetrix mRNA profiling database can provide collaborators with an immediate indication of expression of their gene of interest in the acquired resistant model setting.
Last update
Monday, December 3, 2012
 
Last name GKRETSI
First name VASILIKI
Institution University of Cyprus
Country CYPRUS
Phone 00357-96973885
E-mail vasso.gkretsi@gmail.com
Website http://www.ucy.ac.cy/cancer_biophysics/en
Group leader since (year)
Research interests Current research is focusing on the study of the role of extracellular matrix (ECM), cell adhesion and the cytoskeleton in cancer progression and metastasis. In an attempt to better approximate the real tumor setting and microenvironment, we have developed 3-dimensional (3D) collagen-based culture systems with tunable stiffness to study the molecular mechanism of metastasis in vitro in cancer cells of different invasiveness. This approach takes also into account the cell-ECM interactions in 3D as well as the mechanical forces being exerted on the cells from the ECM. The ultimate goal would be the determination of the molecular mechanism driving cancer cell metastasis in relation to ECM stiffness and the identification of novel potential metastasis biomarkers or therapeutic taregts.
Models 3D in vitro model systems
Methods Spheroid invasion assays, Transwell invasion assay, Migration assays, Wound healing assays, Cell adhesion assays, Cell spreading assays, Culture of breast cancer cells in 3D, qPCR, Western Blotting, Immonoprecipitation, Cell proliferation assays, Immunohistochemistry, Cell staining
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, July 4, 2017
 
Last name GLUKHOVA
First name MARINA
Institution UMR 144 CNRS-Institut Curie, Institut Curie, Centre de Recherche
Country
Phone +33 1 56 24 63 31
E-mail Marina.Glukhova@curie.fr
Website http://www.curie.fr
Group leader since (year) 1995
Research interests Cell-extracellular matrix interactions mediated by integrins in mammary developmentWnt/ß-catenin signaling pathway in mammary tumorigenesisStem/progenitor cells in the adult mouse mammary epithelium
Models Transgenic mice, mouse models of human breast tumors, primary culture of mammary cells, mouse mammary cell lines
Methods Isolation of mouse mammary epithelial cells, 2-D and 3-D cultures, transplantation into the cleared mammary fat pad, FACS, microarrays
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, May 13, 2014
 
Last name GOMIS
First name ROGER
Institution Institute for Research in Biomedicine (IRB Barcelona)
Country SPAIN
Phone +34934039959
E-mail roger.gomis@irbbarcelona.org
Website www.irbbarcelona.org/en/research/growth-control-and-cancer-metastasis
Group leader since (year) 2010
Research interests Intricate signalling networks control cell division, differentiation, movement, organization and death. Understanding how cells read and transform these signals into changes in cell behaviour is a major research focus of our group. Breast cancer cells disobey these signals during tumour progression and metastasis. Metastasis is the final step in 90% of all fatal solid tumours. We aim to understand when, where, and how long metastasis drivers are needed in the process and whether these can be leveraged to improve therapeutic approaches.
Models Genetically engineered mouse models, patient derived samples, human and mouse cancer cell lines
Methods Orthotropic tumor and metastasis models, metastasis colonization assays, 2D and 3D cultures, comics and computational biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, March 8, 2018
 
Last name GOMPEL
First name ANNE
Institution INSERM UMRS 938 Saint Antoine, Paris Paris Descartes University
Country FRANCE
Phone 0033149284692/0033142348768
E-mail anne.gompel@htd.aphp.fr
Website
Group leader since (year)
Research interests human normal breast cells hormonedependency
Models primary cultures of normal human cells xenografts of normal tissues in nude mice biopsies
Methods QPCR, IHC, Western blots, si
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name GONZALEZ SUAREZ
First name EVA
Institution Bellvitge Institute for Biomedica Research (IDIBELL) Cancer Epigenetics and Biology Program (PEBC)
Country
Phone 34 932607500 Ext 3166
E-mail egsuarez@idibell.cat
Website http://www.pebc.cat/grupodetalle.php?idg=15
Group leader since (year) 2008
Research interests Breast cancer and bone metastasis. RANK signaling. Tumor initiating cells. Mechanisms of resistance to current treatments. Inflammation and cancer.
Models 3D cultures, suspension cultures, primary cell cultures, orthotopic transplants of human and mouse tumors, transgenic and KO mouse models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, May 2, 2011
 
Last name GRONER
First name BERND
Institution Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Str. 42, D-60596 Frankfurt am Main, Germany
Country
Phone +49 69 63395180
E-mail groner@em.uni-frankfurt.de
Website http://www.georg-speyer-haus.de
Group leader since (year) 1982
Research interests mammary gland biology, breast cancer, experimental therapeutics, cytokine signaling
Models mammary gland reconstitution, genetically modified mammary stem cells, in vitro differentiation
Methods cleared fat pad transplantation, lentiviral mediated transgenesis
List of transgenic and KO
mice available
No
Comments
(including wish list)
great initiative
Last update
Monday, September 29, 2008
 
Last name GUO
First name WENJUN
Institution Albert Einstein College of Medicine
Country UNITED STATES
Phone 718-678-1276
E-mail wenjun.guo@einstein.yu.edu
Website http://www.einstein.yu.edu/departments/cell-biology/faculty/guo/resear...
Group leader since (year)
Research interests Mammary gland development; mammary stem cells; breast cancer; breast cancer stem cells
Models mouse tumor models; germline and somatic genetic models; human cancer cells
Methods stem cell in vivo and in vitro assays; genetic engineering / genome editing; 3D culture
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, June 19, 2015
 
Last name GUPTA
First name SANJEEV
Institution Lambe Institute for Translational ResearchNational University of Ireland Galway
Country IRELAND
Phone +353 (0)85 1045291
E-mail Sanjeev.Gupta@nuigalway.ie
Website http://www.nuigalway.ie/medicine-nursing-and-health-sciences/medicine/...
Group leader since (year) 2010
Research interests XBP1 is a multitasking transcription factor and a key component of the unfolded protein response. Recently we have shown that NCOA3 is a transcriptional target of XBP1 and plays an important role in optimal activation of the PERK-ATF4 pathway thereby regulating tumour vascularity and invasion. Nuclear receptor coactivator 3 (NCOA3) is an oncogenic coactivator and interacts with nuclear receptors (NR) to enhance the expression of cognate target genes. Our results show that XBP1-mediates anti-estrogen resistance in part through regulating NCOA3. Increased expression of NCOA3 was associated with poor prognosis and higher levels of XBP1 in breast cancer tissues. Our results show that NCOA3 is required for induction of XBP1 during oestrogen stimulation and uncovers a positive feedback regulatory loop that maintains high levels of NCOA3 and XBP1 in breast cancer. Taken together our data identifies XBP1-NCOA3 axis that regulates cell fate decisions in ER-positive breast cancer cells. I hypothesize that XBP1-NCOA3 axis constitutes an important signalling node downstream of activated ERa and an attractive target for therapeutic intervention in ER-positive breast cancer. The main focus of my group is to elucidate how somatic mutations in the genes encoding components of oestrogen signalling regulate the activation and output of XBP1-NCOA3 axis. Additionally, we are evaluating the efficacy of XBP1 and NCOA3 targeting agents for preventing and/or reversing endocrine resistance in breast cancer.
Models cell lines, TMAs, Cancer tissue and pheripheral blood for biomarker studies
Methods GENE EXPRESSION PROFILES, LENTIVIRAL ShRNA, CRISPR-CAS9, CAM FOR ANGIOGENESIS, APOPTOSIS AND UPR
List of transgenic and KO
mice available
No
Comments
(including wish list)
PLEASE CONTACT FOR POSITION IN THE GROUP & COLLABORATIONS
Last update
Tuesday, May 2, 2017
 
Last name GUR DEDEOGLU
First name BALA
Institution Ankara University Biotechnology Institute
Country TURKEY
Phone +905327040106
E-mail gurbala@yahoo.com
Website http://biotek.ankara.edu.tr/author/bala-gur-dedeoglu/#
Group leader since (year) 2012
Research interests miRNAs, drug resistance, identification of miRNA regulated molecular mechanisms that take part in the development, progression and the treatment of breast cancer, bioinformatics; highthroughput data analysis, miRNA-TF-target gene circuits, development and applications of meta-analysis approaches.
Models breast cancer cell lines, patient samples
Methods Microarrays, gene expression (mRNA, miRNA), miRNA-target gene interactions, cell culture assays, protein expression. Bioinformatics; highthroughput data analysis, circuit, network and pathway analysis.
List of transgenic and KO
mice available
No
Comments
(including wish list)
We combine bioinformatics approcahes with molecular biology to define potential biomarkers that take part in breast cancer development, progression and treatment.
Last update
Wednesday, December 12, 2018
 
Last name HAVAS
First name KRISTINA
Institution IFOM- Italian Foundation of Molecular Oncology
Country ITALY
Phone +39 0257 4303278
E-mail kristina.havas@ifom.eu
Website https://www.ifom.eu/en/cancer-research/researchers/kristina-havas-cava...
Group leader since (year) 2016
Research interests We are interested in understanding metabolic reprogramming during the initiation, progression and response of breast cancer using in vivo animal model systems and ex vivo organotypic cultures. We aim to understand how both genetic context and the local environment, shape metabolic reprogramming in breast cancer. Specifically, we are interested in understanding the extent of metabolic plasticity throughout the evolution of breast cancer, from disease onset up to and including therapeutic response. Through more thorough understanding of this key hallmark of breast cancer we aim to design strategies for more effective patient treatment.
Models We use a combination of mouse models and organoid cultures to isolate cells which survive therapeutic treatment. This approach has allowed us to characterize residual breast cancer using multi-tiered systems biology approaches. Our goal is to utilize these platforms to identify more effective therapeutic options for breast cancer patients
Methods primary organoid cultureacyl-biotin exchange
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
We are a young group interested in understanding how metabolism impacts upon therapeutic resistance and cancer progression. We are always open to discussing new collaborations or even just ideas!
Last update
Tuesday, June 27, 2017
 
Last name HELGUERO
First name LUISA
Institution Department of Medical Sciences, University of Aveiro
Country PORTUGAL
Phone
E-mail luisa.helguero@ua.pt
Website http://www.ua.pt/ibimed/PageText.aspx?id=19419
Group leader since (year) 2012
Research interests Our main interest is to understand how mammary epithelial cell differentiation is regulated, and the links to cancer. We are currently studying the role of adaptative stress responses and protein methylases in the regulation of EMT and in estrogen receptor signalling.
Models cell lines and syngeneic mouse mammary tumour models
Methods all that are commonly available at any cell and molecular biology lab
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, May 1, 2018
 
Last name HILKENS
First name JOHN
Institution Netherlands Cancer Institute
Country
Phone +31 20 512 2018
E-mail j.hilkens@nki.nl
Website http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Ge...
Group leader since (year) 1982
Research interests The aim of my laboratory is to identify and study novel genes involved in breast cancer and unravel the collaborating genetic pathways leading to breast cancer and breast cancer progression using mouse mammary tumor virus (MMTV) induced insertional mutagenesis in mouse models. genes of interest: R-spondin genes, Irs genes and membrane associated mucins (MUC1)
Models various mouse models including K14-cre; p53f/f and MMTV cNeu transgenics
Methods High throughput in vivo MMTV mediated insertional mutagenesis screens, protein biochemistry, retroviral transduction, in vivo tumorigeneicity and metastasis assay's
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name HOPKINS
First name ANN
Institution Royal College of Surgeons in Ireland
Country IRELAND
Phone +35318093858
E-mail annhopkins@rcsi.ie
Website https://research1.rcsi.ie/pi/annhopkins/index.asp
Group leader since (year) 2005
Research interests - Altered cell-cell and cell-matrix adhesion in breast cancer progression;- The role of junction adhesion molecule-A (JAM-A) in breast cancer invasion;- Lipid rafts as modulators of cell migration;- Breast progenitor cells
Models Primary cultures of human breast tumoursTissue microarrays3-dimensional cell culture models
Methods Protein biochemistryConfocal microscopyFunctional assays relevant to cell motility
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, December 3, 2012
 
Last name HOVEY
First name RUSS
Institution University of California, Davis
Country UNITED STATES
Phone 5307521682
E-mail rchovey@ucdavis.edu
Website http://animalscience.ucdavis.edu/hoveylab/Index.html
Group leader since (year) 2002
Research interests mammary gland biology, breast cancer, lactation, endocrinology
Models a range of approaches and techniques in rodents and large animals
Methods biopsy, cell culture, in vivo genetic manipulation, transplants, milk sampling and analysis
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, June 18, 2014
 
Last name HOWARD
First name BEATRICE
Institution Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London
Country
Phone + 44 (0) 207 153 5177
E-mail beatrice.howard@icr.ac.uk
Website http://www.breakthroughcentre.org.uk/research_groups/gene_function/bre...
Group leader since (year)
Research interests mammary morphogenetic events with relevance to breast cancer etiology: Neuregulin3 (Nrg3) and Erbb4 signalling, embryonic mammary gland development, mammary lineage commitment and differentiation
Models knockout and transgenic mice, ex vivo culture
Methods general molecular, cellular and developmental biology techniques, qPCR, IF, ISH, protein analysis, microdissection, etc.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, August 25, 2008
 
Last name HUGHES
First name THOMAS A
Institution University of Leeds
Country UNITED KINGDOM
Phone +44 113 3431984
E-mail t.hughes@leeds.ac.uk
Website http://medhealth.leeds.ac.uk/info/320/molecular_gastroenterology/451/
Group leader since (year) 2008
Research interests gene regulation mechanisms; cancer stroma; cancer microenvironment; biomarkers; novel therapeutics; nanomedicine
Models cell lines; human tissue (archival; fresh/frozen; ex vivo)
Methods in vitro biochemistry; molecular biology; cell line work; in vivo models; analysis of patient material and clinical trials; systems biology and mathematical approaches
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, June 6, 2016
 
Last name HYNES
First name NANCY
Institution Friedrich Miescher Institute for Biomedical Research
Country
Phone 41 61 697 8107
E-mail hynes@fmi.ch
Website http://www.fmi.ch/hynes.n
Group leader since (year) 1981
Research interests Breast cancer, ErbB family of receptor tyrosine kinases, mammary gland development, FGFRs, Wnt pathway, cell migration,
Models Transgenic mammary tumor models, 4T1 mammary cancer model, human tumor xenograft models. mouse premature aging model
Methods Protein analysis, migration, FACs, animal cancer models, etc
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name IGGO
First name RICHARD
Institution Bergonie Cancer Institute, University of Bordeaux
Country
Phone 00 33 5 56 33 04 23
E-mail richard.iggo@me.com
Website http://www.bergonie.org/fr/basic-research/richard-iggo.html
Group leader since (year) 1991
Research interests Prediction of response to chemotherapy using gene signatures. Role of p53 in breast cancer. Quantitative transformation of normal mammary epithelial cells.
Models Orthotopic xenografts in NOD/SCID mouse mammary glands.
Methods Lentiviral infection of HMECs and BPECs to express oncogenes and inactivate tumour suppressor genes. Affymetrix expression and SNP chips from clinical samples.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, December 8, 2009
 
Last name JONKERS
First name JOS
Institution Netherlands Cancer Institute
Country
Phone +31-20-5122000
E-mail j.jonkers@nki.nl
Website http://research.nki.nl/molbio/Groups/jonkers/jonkersgroup.htm
Group leader since (year) 2003
Research interests BRCA1- and BRCA2-associated breast cancer, E-cadherin-mutated lobular breast cancer, inflammation and cancer, cancer stem cells, targeted anticancer therapeutics
Models Conditional knockout and transgenic mice, in vitro cultures, orthotopic grafting models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name KAENEL
First name PHILIP
Institution Department for Clinical Research University of Bern
Country SWITZERLAND
Phone
E-mail philip.kaenel@dkf.unibe.ch
Website
Group leader since (year)
Research interests Ephrin-B2 and EphB4 in mammary gland development
Models
Methods Flow cytometry, in vivo assays, in vitro colony-forming and mammopshere assays, confocal microscopy
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name KATAJISTO
First name PEKKA
Institution University of Helsinki
Country FINLAND
Phone +358 40 708 5349
E-mail pekka.katajisto@helsinki.fi
Website http://www.biocenter.helsinki.fi/bi/katajisto/index.html
Group leader since (year) 2013
Research interests Somatic stem cells, asymmetric cell division, fate determination, stem cell - niche interactions
Models mammary gland reconstitution, age-selective asymmetry in cell division.
Methods mammary stem cell assays, lentiviral targeting of mammary stem cells,
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, October 2, 2014
 
Last name KHALED
First name WALID
Institution University of CambridgeDepartment of Pharmacology
Country UNITED KINGDOM
Phone +441223334035
E-mail wtk22@cam.ac.uk
Website http://www.phar.cam.ac.uk/research/Khaled
Group leader since (year) 2013
Research interests Triple negative breast cancer, High throughput genetic screens, Naked mole-rats resistance to cancer
Models BCL11A mouse models, Crispr/Cas9, piggybac
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, December 2, 2014
 
Last name KLEFSTRÖM
First name JUHA
Institution Medical Faculty, University of Helsinki
Country FINLAND
Phone +358443773876
E-mail juha.klefstrom@helsinki.fi
Website http://research.med.helsinki.fi/cancerbio/klefstrom/
Group leader since (year) 2003
Research interests Breast Cancer Biology, Functional Genomics & Genetic engineering, RNAi and Genome Editing by CRISPR/Cas9, Tissue Engineering, Drug Discovery, Personalized Cancer Medicine
Models Genetically Engineered Mouse Models of Cancer, 3D culture, Ex vivo and in vivo Models of Cancer, patient-derived explants and transplantation models, syngraft models
Methods Confocal fluorescence microscopy, viral gene transfer methods, chemical biology approaches
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, February 18, 2016
 
Last name KLEIBL
First name ZDENEK
Institution Institute of biochemistry and experimental oncology, First faculty of medicine, Charles university in Prague
Country CZECH REPUBLIC
Phone +420 224965745
E-mail zdekleje@lf1.cuni.cz
Website
Group leader since (year)
Research interests breast cancer susceptibility (analysis of major predisposing genes, low penetrant genes and gene modifyers) in familial and sporadic breast cancer populations analysis of defects in DNA repair in mammary tumorigenesis (role of BRCA1 splicing variants in DSB repair kinetics) breast cancer pathogenesis (identification of somatic alterations in breast cancer lesions)
Models genetic material from >500 high-risk families (HBC, HBOC, HOC), >500 sporadic BC patients, non cancer controls. Stable breast cancer cell lines (MCF-7, HCC1936, MBA-MB231, EM-G3 (derived from early progenitors)). Primary MEC from BRCA1 mtation carriers and controls.
Methods Genotyping: HRM, dHPLC, PTT, MLPA, sequencing, fragment analysis. In vitro studies: Stable transfections, RNAi, qPCR, FL microscopy, WB Ex vivo studies: arrays (Phalanx), ms-MLPA, genotyping
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, February 17, 2011
 
Last name LE PROVOST
First name FABIENNE
Institution Laboratoire de Génétique Animale et Biologie Intégrative, Institut National de Recherche Agronomique (INRA)
Country FRANCE
Phone 33 1 34 65 25 69
E-mail Fabienne.LeProvost@jouy.inra.fr
Website http://www4.jouy.inra.fr/gabi
Group leader since (year) 2003
Research interests Mouse normal mammary gland development and differentiation. microRNA involvement in the mammary gland development and in lactation.
Models mouse models
Methods transgenic mice, transcriptomic analysis (RT-qPCR, microarray, RNA-seq), histolgy, Immunohistology, transplantation.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, March 20, 2012
 
Last name LENFANT
First name FRANCOISE
Institution INSERM U1048CHU Rangueil1 Avenue J. POUlhèsBP 8422531 432 Toulouse cedex 04
Country FRANCE
Phone 0033531224093
E-mail Francoise.Lenfant@inserm.fr
Website http://www.i2mc.inserm.fr/index.php/en/research-teams/team-9
Group leader since (year)
Research interests Estrogen Receptor ERa, Nuclear and membrane effects, mammary develpment and mammary stem cellsCarcinogenesis
Models Transgenic mice models mutated for different functions of ERaand for cell-specific functions of ERa
Methods Mammary development, stem cell purification, analysis of vascularization in tumors
List of transgenic and KO
mice available
No
Comments
(including wish list)
The goal of our lab is to dissect the modulation of Estrogen Receptor ERa in physiology and physiopathology
Last update
Friday, October 26, 2018
 
Last name LI
First name CARMAN
Institution Harvard Medical School
Country UNITED STATES
Phone
E-mail Carman_Li@hms.harvard.edu
Website
Group leader since (year)
Research interests Breast tumor and development, with a particular focus on the microenvironment and cell-cell interactions.
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Sunday, June 25, 2017
 
Last name LI
First name YI
Institution Baylor College of Medicine
Country UNITED STATES
Phone 713-798-3963
E-mail liyi@bcm.edu
Website
Group leader since (year) 2002
Research interests Breast Cancer, mouse model, ErbB2, Wnt, ID4, STAT5, MAP3K3, TVA, RCAS
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, June 27, 2012
 
Last name LLOBET-NAVAS
First name DAVID
Institution Institute of Genetic Medicine-Newcastle University
Country UNITED KINGDOM
Phone +44(0) 191 241 8631
E-mail david.llobet-navas@ncl.ac.uk
Website http://www.ncl.ac.uk/igm/staff/profile/david.llobet-navas
Group leader since (year) 2016
Research interests mammary gland development, breast cancer, microRNAs, obesity, endometrial cancer, stem cells.
Models
Methods In vitro and in vivo models related to breast cancer and endometrial cancer. RNA-sequencing, reprogramming.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, December 16, 2016
 
Last name LU
First name PAUL
Institution Paterson Institute for Cancer Research, Wellcome Trust Center for Cell Matrix Research, University of Manchester
Country UNITED KINGDOM
Phone +441614463917
E-mail paul.lu@manchester.ac.uk
Website http://www.wellcome-matrix.org/research-groups/paul-lu.html
Group leader since (year) 2010
Research interests 1). What are the roles of stromal microenvironment in regulating adult stem cells? This is an important question because adult stem cells are essential for normal remodelling and physiology of the mammary gland and are targeted in certain breast cancers. 2). How is epithelial polarity maintained in the breast? Tissue polarity is a key feature of organ integrity and loss of epithelial polarity is often observed in human breast cancer. Here we focus on the role of a group of cell polarity genes in morphogenesis, stem cell biology and tumorigenesis. 3). What role does receptor tyrosine kinase (RTK) signalling play in mammary gland epithelium-stroma interactions? And how is it regulated? RTK signalling is one of the five major signalling pathways in metazoan and is upregulated in most breast cancers. We focus on how RTK signalling is inhibited by Sprouty genes in the breast.
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, June 20, 2012
 
Last name MANDA
First name KATRIN
Institution Department of Radiotherapy and Radiation Oncology, University Medical Centre Rostock
Country GERMANY
Phone +493814949110
E-mail katrin.manda@uni-rostock.de
Website http://strahlentherapie.med.uni-rostock.de/
Group leader since (year) 2007
Research interests Normal mammary stem cells; radiation-induced carcinogenesis in breast; mammary gland development.
Models cell lines; 2D and 3D models; mammary fat-pad model; primary cell culture.
Methods Irradiation of cell cultures, colony forming assays, flow cytometry, measurement of DNA repair (gH2AX-assay), Western blot, immunohistochemistry, ELISA, PCR…
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, July 21, 2015
 
Last name MARKKANEN
First name ENNI
Institution University of Zurich
Country SWITZERLAND
Phone +41 44 635 8770
E-mail enni.markkanen@vetpharm.uzh.ch
Website http://www.vpt.uzh.ch/en/research/groupmarkkanen.html
Group leader since (year) 2015
Research interests Breast cancer, Cancer research, Canine mammary tumours, Comparative oncology, Tumour stroma, Tumour microenvironment, DNA damage, DNA repair
Models Clinical tumour samples, Cell culture, Primary cell lines, Mouse models
Methods Laser-Capture Microdissection, FFPE Next-Generation Sequencing, RT-qPCR, IHC, Western blot, siRNA, Comet assay
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, December 1, 2017
 
Last name MARTIN
First name STEWART
Institution University of Nottingham, School of Medicine, Division of Cancer and Stem Cells, Department of Clinical Oncology, Nottingham City Hospital, Nottingham NG5 1PB
Country UNITED KINGDOM
Phone +44 (0)1158231846
E-mail stewart.martin@nottingham.ac.uk
Website http://www.nottingham.ac.uk/medicine/people/stewart.martin
Group leader since (year) 2000
Research interests Prognostic and predictive biomarkers; Proteases (Calpains and Calpastatin); REDOX metabolism (biomarkers and novel inhibitors); Lymphatic cell biology (lymphovasular invasion);Radiation Biology (predictive biomarkers of radiotheraputic response, drug/radiation interactions).
Models In vitro models (2D and 3D (matrigel)) with normal and malignant cells +/- stromal interactions; vascular and lymphatic endothelium (primary and established lines); tissue microarrays (histopathology based studies).
Methods In vitro: invasion (incl endothelial transmigration), adhesion and migration (haptotaxis); usual molecular techniques (Westerns, Q-RT-PCR, si- & shRNA etc); Immunohistochemistry; Cell X-ray irradiation facility (+/- hypoxia)
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, December 1, 2016
 
Last name MAURER
First name JOCHEN
Institution University Hospital Aachen (RWTH)
Country GERMANY
Phone +492418037051
E-mail jmaurer@ukaachen.de
Website https://www.researchgate.net/profile/Jochen_Maurer
Group leader since (year) 2013
Research interests Breast cancer, cancer stem cells, developmental biology, expression profiles, molecular oncology, triple negative breast cancer, patient specific medicine, Kinase inhbitors, cancer stem cell differentiation
Models 3D embedded cultures, patient derived cell lines, xenografts, PDX models
Methods Microarrays, flow cytometry, lentiviral transgenesis, high throughput screening, automated microscopy
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, March 8, 2018
 
Last name MERCURIO
First name ARTHUR
Institution University of Massachusetts Medical School
Country UNITED STATES
Phone 508-856-8676
E-mail arthur.mercurio@umassmed.edu
Website http://profiles.umassmed.edu/profiles/display/133502
Group leader since (year) 1985
Research interests Mammary gland development and breast cancer; Integrins and integrin signaling; VEGF and VEGF receptors; cancer stem cells; extracellular matrix; laminins
Models PDX tumors; transgenic mouse models for studying integrins and VEGF receptors
Methods Integrin and ECM functional assays; stem cell assays; molecular cell biology of cancer; analysis of human tumors
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, October 31, 2014
 
Last name NORUM
First name JENS HENRIK
Institution The Norwegian Radium Hospital Oslo University Hospital
Country NORWAY
Phone +47-22781483
E-mail jennor@rr-research.no
Website http://ous-research.no/home/sorlie/Group%20members/12739
Group leader since (year)
Research interests Breast cancer cell of origin; Hedgehog and Wnt signalling; Lgr5; breast cancer progression
Models Chemically-induced mammary tumour models; transgenic mice; PDX models; humanised mouse models
Methods Lineage-tracing; PBMC induced humanisation; in situ hybridisation technologies
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, December 2, 2016
 
Last name OAKES
First name SAMANTHA
Institution Garvan Institute of Medical Research
Country AUSTRALIA
Phone 61 (2) 9295 8426
E-mail s.oakes@garvan.org.au
Website http://www.garvan.org.au/research/cancer/cancer-biology/cell-survival/...
Group leader since (year) 2013
Research interests The focus of my research is to discover the ways in which cancer cells avoid death, survive, grow and resist therapy. By understanding these mechanisms I aim to discovery new therapeutic strategies capable of eradicating disease in patients diagnosed with breast cancer. I hope to refine these new therapies in combination with conventional chemotherapy and target them to cancer cells so that patients will no longer have to suffer the burden of the dose limiting toxic side effects so commonly associated with routine cancer treatment. Other research projects include understanding the cues that regulate mammary development as these mechanisms may be dysregulated during breast cancer progression. I have contributed to the understanding of the regulation of mammary alveolar differentiation and demonstrated that the transcription factor Elf5 is the master regulator of the alveolar (milk producing) cell lineages during pregnancy. Importantly we discovered that Elf5 segregates with the steroid receptor positive cells in the mammary gland. This work has continued in my parent laboratory where we are now translating these findings for human breast cancer and discovered that Elf5 similarly drives anti-estrogen resistance in breast cancer. By targeting these mechanisms we may be able to alleviate the often fatal therapeutic resistant breast cancer recurrences that occur in a small proportion of patients treated with Tamoxifen. We further have discovered a novel gene called Jersey that is essential for mammary cell viability. Mutation of Jersey results in mammary cellular apoptosis resulting in severely perturbed alveolar functional differentiation and a consequent inability to nurse pups. Mutation of the Jersey gene results in constitutive activation of the Jersey pathway, never before linked to mammary development. The Jersey mutation also results in faster cancer growth.
Models mouse models, 2D and 3D breast cancer models, patient derived xenografts
Methods mammary transplantation, cell sorting, cloning, FACS, Immunohistochemistry, mouse models, breast Cancer 2D and 3D tissue culture, western Blotting, pre-clinical mouse models, genetic engineering, quantitative PCR, genomics, confocal Microscopy, routine histology and microscopy
List of transgenic and KO
mice available
No
Comments
(including wish list)
Keywords: Mammary gland development, breast development, breast cancer, apoptosis, cell survival, cell death, differentiation, chemotherapy, cytotoxic therapy, pre-clinical models, chemo-resistance, metastasis, tumour progression
Last update
Wednesday, June 18, 2014
 
Last name OREND
First name GERTRAUD
Institution INSERM U682, De l`homéostasie tissulaire au cancer et à l`inflammation Equipe: Impact du microenvironnement sur l`angiogenèse et l`invasion tumorale
Country FRANCE
Phone 33 (0)3 88 27 53 55
E-mail gertraud.orend@inserm.u-strasbg.fr
Website http://u682-inserm.u-strasbg.fr
Group leader since (year) 2002
Research interests Extracellular matrix in tissue homeostasis, inflammation, angiogenesis, metastasis, stem cells, tenascin-C, laminins
Models 3D cultures, ex vivo culture models (HMECs...), transgenic and KO tenascin-C and laminin-111 mice
Methods cell culture assays, BiAcore, biochemistry (western blot, IP, QPCR..), tissue analysis
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, November 19, 2009
 
Last name ORIAN-ROUSSEAU
First name VÉRONIQUE
Institution Karlsruhe Institute of Technology, Institute for Toxicology and Genetics
Country
Phone +497247826523
E-mail veronique.orian-rousseau@kit.edu
Website http://itgmv1.fzk.de/itg/orian-rousseau/orian-rousseau.html
Group leader since (year) 2003
Research interests Molecular mechanisms involved in tumor progression, Receptor Tyrosine Kinases (EGFR, c-Met, VEGFR..) activation and internalisation, Cell Adhesion Molecules (in particular CD44, ICAM), Role of CD44 in Breast Cancer Stem cells, Signal Transduction
Models CD44 knock out, Xenograft, pancreas orthotopic models
Methods KO technology, Transgenic, Angiogenesis assays,
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
CD44 floxed mice
Last update
Wednesday, December 2, 2009
 
Last name PAGES
First name GILLES
Institution University of Nice Sophia Antipolis UMR CNRS 6543
Country
Phone 00 33 4 92 03 12 31
E-mail gpages@unice.fr
Website
Group leader since (year) 1999
Research interests Normal and tumor angiogenesis. We are looking at the regulation of angiogenic factor VEGf and IL-8 in particular at the post transcriptional level. We are studying mRNA binding protein that destabilizes the mRNA. We are looking at the loss of mRNA degradative protein in breast cancer on tumor cell lines and on tumor samples. We are also looking at the effect of targetted therapy on the expression of these proteins
Models Cell with different metastatic potential with inducible expression of mRNA degradative protein, tumor samples
Methods Stable and transient transfection of genes of interest. In vivo imaging of tumor xenografts of cells with expression of luciferase. Determination of angiogenic factor by ELISA; Reporter genes (promoters and 3'UTR)
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name PAREDES
First name JOANA
Institution i3S - Institute of Investigation and Innovation in Health - University of Porto- EPIC (EPithelial Interactions in Cancer) lab
Country PORTUGAL
Phone +351 220408800 (ext. 6120)
E-mail jparedes@ipatimup.pt
Website www.i3s.up.pt
Group leader since (year) 2009
Research interests Breast cancer and mammary gland development, cell-cell adhesion, P-cadherin, E-cadherin, cell-ECM adhesion, integrins, cadherins signalling, cancer stem cells, breast cancer metastasis, cell polarity
Models normal and cancer cell cultures, 3D cell cultures, xenograft nude mice, metastatic tropic cell lines
Methods Time-lapse microscopy, confocal microscopy, FACS, Western-blot, qRT-PCR, aggregation and invasion assays, in situ proximity ligation, cell biology assays
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, December 9, 2015
 
Last name PATTABIRAMAN
First name DIWAKAR
Institution Dartmouth College, Norris Cotton Cancer Center
Country UNITED STATES
Phone
E-mail raman@dartmouth.edu
Website http://geiselmed.dartmouth.edu/raman/
Group leader since (year) 2017
Research interests Breast cancer, cancer stem cells, EMT and MET
Models Human cell lines and mouse models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, December 1, 2017
 
Last name PELICCI
First name PIER GIUSEPPE
Institution Experimental Oncology European Institute of Oncology and the Campus IFOM-IEO
Country
Phone 0039-02-57489831
E-mail piergiuseppe.pelicci@ieo.eu
Website http://www.ifom-ieo-campus.it/
Group leader since (year) 1987
Research interests 1.Hematopoietic stem cells and Acute Myeloid Leukemias 2. Breast stem cells and breast cancer 3.Effects of checkpoint activation on tissue homeostasis and molecular mechanisms of aging 4. Epigenetics and environmental cancer risk assessment
Models Mammospheres; KO and transgenic mice, humanized mouse, conditional and constitutive models
Methods Cell culture (primary cell culture; cell lines) and mouse models; 3D cultures; xenografts; standard molecular and cell biology techniques; time-lapse microscopy; FACS sorting; siRNA technology; DNA microarrays, tissue microarrays; ChIP, ChIP-chip and ChIP-Seq.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, February 19, 2015
 
Last name PICARD
First name DIDIER
Institution Department of Cell BiologyUniversity of Geneva
Country SWITZERLAND
Phone +41223796813
E-mail didier.picard@unige.ch
Website https://www.picard.ch
Group leader since (year) 1990
Research interests Estrogen receptors; Estrogen signaling; Molecular biology of breast cancer; Signaling crosstalk
Models Human cell lines
Methods Cell and molecular biology; omics
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, September 28, 2018
 
Last name PIETERSEN
First name ALEXANDRA
Institution National Cancer Centre Singapore & Duke-NUS Graduate Medical School
Country SINGAPORE
Phone +65 6223 7241
E-mail apietersen@gmail.com
Website www.pietersenlab.com
Group leader since (year) 2008
Research interests Regulation of the mammary stem cell hierarchy and its relation to breast cancer. We use mouse models to investigate the role of proto-oncogenes in regulation of stem cells, lineage restriction and differentiation. We have a particular interest in the role of epigenetic modifiers in these processes.
Models transgenic mice (KO, GFP reporters and conditional transgenes for various oncogenes)
Methods multiparameter flow cytometry, cleared fat pad transplantation, in vitro colony-forming & differentiation assays, mouse models of breast cancer, histology and (wholemount) fluorescence imaging
List of transgenic and KO
mice available
No
Comments
(including wish list)
Note that European candidates will be eligible to apply for an EMBO fellowship to work in this lab
Last update
Thursday, December 1, 2011
 
Last name PLANELLES
First name LOURDES
Institution National Center for Biotechnology, CNB/CSIC
Country SPAIN
Phone +34915854855
E-mail lplanelles@cnb.csic.es
Website http://www.cnb.csic.es/
Group leader since (year) 2007
Research interests Human breast cancer and mammary gland biology, APRIL/BAFF proteins, signaling, tumor immunology, immune system
Models Cell lines, mouse models, human pathologies
Methods KO and transgenic mice, orthotopic tumors, RNA and protein analysis, IHQ, flow citometry, primary cell manipulation, lymphocytes purification
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, February 27, 2013
 
Last name PUJANA
First name MIQUEL ANGEL
Institution Procure, Catalan Institute of Oncology, IDIBELL
Country SPAIN
Phone +34932607463
E-mail miguelangel.pujana@gmail.com
Website www.cancersytemsbiology.cat; http://ico.gencat.cat/es/recerca/Programa...
Group leader since (year) 2005
Research interests Cancer biology, therapy, resistance, network models, systems biology, genetics, BRCA1/2, triple-negative, endocrine rsistance
Models Transgenic Rosa-HMMR, loss of function Brca1/p53, cell lines resistant for endocrine therapy and mTOR inhibition, PDXs of TNBC and endocrine resistance
Methods Genetics, data integration and modeling, functional genomics, synergistic drug combinations, predictions, resistance
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Friday, March 9, 2018
 
Last name RIETHDORF
First name SABINE
Institution Institute of Tumor Biology, University Medical center Hamburg-Eppendorf, Germany
Country
Phone 0049-40-42803-2628
E-mail s.riethdorf@uke.uni-hamburg.de
Website http://www.uke.uni-hamburg.de/institute/tumorbiologie
Group leader since (year) >10
Research interests Disseminated and circulating tumor cells in bone marrow and blood, molecular and phenotypical characterization of DTC, CTC, breast cancer, stem cells
Models
Methods Enrichment, detection and characterization of DTC, CTC, automatic detection systems, in situ hybridization (DNA; RNA)
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, August 25, 2008
 
Last name RIO
First name MARIE-CHRISTINE
Institution Institut de Génétique et de Biologie Moléculaire et Cellulaire
Country
Phone 0388653424
E-mail rio@igbmc.u-strasbg.fr
Website
Group leader since (year) 1989
Research interests Molecular biology of breast cancers. Normal and pathological function of few genes: pS2/TFF1, ST3/MMP11, MLN64, MLN51 and TRAF4, all cloned in the laboratory. Proteomic of breast cancers
Models Knock-out mice for the genes cited above. Several models of tumorigenesis in mice
Methods Cellular and molecular biology Transgenic mice
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name RODRIGUEZ BARRUECO
First name RUTH
Institution Universitat de Barcelona - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)
Country SPAIN
Phone (+34) 689549390
E-mail rrodriguez@idibell.cat
Website
Group leader since (year) 2018
Research interests Breast cancer and mammary gland development Targeted therapies, resistance to treatment, metastasis, micronevironment, breast cancer stem cells properties CRISPR libraries, shRNA libraries. Whole genome and funtion focused screenings. Glycosylation and breast cancer microRNAs in breast cancer and mammary gland development
Models
Methods Generation of CRISPR libraries. shRNAs and CRISPR screenings. Cell culture, 3D cultures, Flow cytometry, mouse models, NGS.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, June 18, 2018
 
Last name ROTTENBERG
First name SVEN
Institution Institute of Animal Pathology, Vetsuisse Faculty, University of Bern
Country
Phone +41 (0)31 6312395
E-mail sven.rottenberg@vetsuisse.unibe.ch
Website under construction
Group leader since (year) 2012
Research interests mouse models for anti-cancer drug resistance
Models matched drug-naïve and -resistant mammary tumors derived from K14Cre, Brca1F/F, p53F/F; K14Cre, Brca2F/F, p53F/F models
Methods various assays to investigate DNA damage, drug uptake, in vivo drug intervention studies, shRNA and CRISPR-Cas9- based screens, 3D cancer organoid cultures of mouse mammary tumors
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, March 27, 2015
 
Last name RUSSNES
First name HEGE G.
Institution Dept. of cancer genetics, Institute for cancer research and dept. of pathology, Oslo University Hospital
Country NORWAY
Phone +4747300971
E-mail hegrus@rr-research.no
Website http://ous-research.no/russnes/
Group leader since (year) 2014
Research interests Breast cancer molecular classification, integration analyses, intra tumor heterogeneitet, biomarkers for monitoring (CTC, DTC, ctDNA), tumor evolution
Models Only human samples (clinical trials, cohort studies)
Methods DNA alterations (SNP arrays, DNA seq), gene expression (arrays, RNAseq), digital PCR, Nanostring, Cellsearch, FISH, ImmunoFISH, IHC
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, May 26, 2016
 
Last name SAHAI
First name ERIK
Institution Cancer Research UK
Country UNITED KINGDOM
Phone
E-mail erik.sahai@cancer.org.uk
Website
Group leader since (year) 2004
Research interests Invasion and metastasis Tumour Microenvironment Cancer associated fibroblasts
Models Cell lines - 4T1, MDAMB231, MDAMB468, MTLn3E Mouse model - MMTV-PyMT
Methods Organotypic cultures Intravital imaging
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, February 22, 2011
 
Last name SCHEEL
First name CHRISTINA
Institution Helmholtz Center Munich
Country GERMANY
Phone +49-89-3187-2012
E-mail christina.scheel@helmholtz-muenchen.de
Website http://www.helmholtz-muenchen.de/en/isf/research/groups/mammary-stem-c...
Group leader since (year) 2012
Research interests Mammary gland development: branching morphogenesis and alveologenesis, human organoid assays, epithelial plasticity, cell fate decisions, developmental pathways, epithelial-mesenchymal transition (EMT), breast cancer metastasis, metastatic colonisation
Models Primary human tissue-based organoid assays, genetic manipulation of culture models, cell line-derivation, standard cell and molecular biology
Methods See models, heavy on FACS and confocal-microscopy, live cell imaging
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, February 10, 2015
 
Last name SCHMITT
First name FERNANDO
Institution IPATIMUP, Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias, s/n4200-465 PortoPortugalRua Dr. Roberto Frias, s/n
Country
Phone +351-225570700
E-mail fernando.schmitt@ipatimup.pt
Website http://www.ipatimup.pt
Group leader since (year) 1995
Research interests Breast cancer pathology; basal-like carcinomas; basal cell markers; P-cadehrin role in breast carcinogenesis: regulation and function; HER-2/EGFR-targeted therapy resistance; vitamin D effect in controlling breast cancer; PTEN role in breast cancer
Models In vitro cell culture; breast cancer tissue series; tissue microarrays (TMAs); mice xenografts
Methods Microscopy; immunohisto/cytochemistry; cell culture; western-blot; immunoprecipitation; siRNA technology; real-time PCR; cell invasion and aggregation assays; time-lapse microscopy; proteomics; cDNA cloning; luciferase-reporter assays
List of transgenic and KO
mice available
No
Comments
(including wish list)
None
Last update
Thursday, December 9, 2010
 
Last name SCHOENENBERGER
First name CORA-ANN
Institution Institute for Chemistry, University of Basel
Country SWITZERLAND
Phone 0041812673846
E-mail Cora-ann.schoenenberger@unibas.ch
Website
Group leader since (year) 1998
Research interests cytoskeleton (cytoplasmic and nuclear actin), mechanobiology, mechanical properties of mammary cancer
Models Cell culture (2D & 3D), microfluidics
Methods standard biochemical & molecular techniques, light- and electronmicroscopy, microfluidics
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, May 6, 2015
 
Last name SCHREIBMAYER
First name WOLFGANG
Institution Medical University of Graz; Research Unit on "Ion Channels in Cancer Biology"
Country AUSTRIA
Phone 0043 (0) 316 380 4155
E-mail W.Schreibmayer@gmx.at
Website http://biophysik.medunigraz.at/forschung/research-unit-ion-channels-an...
Group leader since (year) 1985
Research interests In 2015, the Research Unit on “Ion Channels and Cancer Biology” was raised at Graz Medical University (MUG). This Research Unit is dedicated to the investigation of transmembrane ion channels in the plasma membrane of tumor cells and how they act as oncoproteins causing the and contributing to the significant “Hallmarks of Cancer” of malignant cells. Research goals are (i) apprehension of the transduction of extracellular signals such as neurotransmitters, growth factors and mechanical stress by ion channels within the plasma membrane, (ii) the malfunction of this process under pathophysiological conditions when cells undergo malignant transformation and (iii) translational application of insight gained at the basic science level, particularly the establishment of new prognostic markers, evaluation of new drugable targets and the development of new medication for the therapy of cancer.The comprehensive Research Unit on “Ion Channels and Cancer Biology” is located both at MUGs preclinical Institute for Biophysics and the Oncology Department.Focus on G-Protein activated Potassium Channels (GIRKs), mechanosensitive Ion Channels (PIEZO) and breast cancer.
Models benign and malign mammary epithelial celllines. CAM Assay.
Methods Electrophysiology: Two Electrode Voltage Clamp / Patch Clamp / Single Channel Recording.Fluorescence Microscopy: cLSM.Time Lapse Microscopy: Motility /Migration.Molecular Biology: fabrication of Genome integrated overexpression /knockdown.Cell Biology: vital parameter assays.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, June 25, 2015
 
Last name SCHULER
First name LINDA
Institution University of Wisconsin--Madison
Country UNITED STATES
Phone 001-608-263-9825
E-mail schulerl@svm.vetmed.wisc.edu
Website
Group leader since (year) long time
Research interests hormonal contributions (especially prolactin) to the development, progression and therapeutic responsiveness of breast cancer
Models human breast cancer cell lines, NRL-PRL transgenic mouse model
Methods in vitro and in vivo
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name SERRA
First name VIOLETA
Institution Vall d'Hebron Institute of Oncology - Barcelona
Country SPAIN
Phone +34 93 2746766
E-mail vserra@vhio.net
Website http://www.vhio.net/research/preclinical-research/experimental-therape...
Group leader since (year) 2014
Research interests Studying early molecular responses following PI3K inhibition to rationally design novel combination therapy in breast cancer. Developing predictive and pharmacodynamic biomarkers of PI3K-pathway inhibitors. •Unveiling novel mechanisms of resistance against targeted therapies in germline BRCA1/2 breast cancer.
Models Establishing a patient tumor-derived breast cancer preclinical model to explore hypothesis-based combinatorial therapies.
Methods
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Thursday, November 8, 2018
 
Last name SHARMA
First name PRIYANKA
Institution Center for Genomic Regulation
Country SPAIN
Phone 602359008
E-mail priyanka.sharma@crg.eu
Website https://www.crg.eu/en/programmes-groups/beato-lab
Group leader since (year)
Research interests
Models T47D cell line and steroid hormone regulation
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
MIGUEL Beato LAB
Last update
Tuesday, December 18, 2018
 
Last name SIERRA
First name ANGELS
Institution IDIBELL
Country
Phone 34 93 2607429
E-mail asierra@idibell.org
Website http://www.idibell.org/
Group leader since (year) 1997
Research interests Apoptotis, Breast cancer, Diagnostic markers, Metastasis pathogenesis, New diagnostic tools
Models Metastatic variants from human breast carcinomas, Brain and lung metastasis models in nude mice, Primary cultures of metastatic cells
Methods Bioinformatics, Cell biology, IHC, Proteomics, Tissue array
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name SIMIAN
First name MARINA
Institution Instituto de Oncología "Angel H. Roffo"
Country ARGENTINA
Phone +5491153856555
E-mail marina.simian@galuzzi.com
Website
Group leader since (year) 2006
Research interests Tumor microenvironment and tamoxifen resistance, estrogen receptor-integrin cross talk, progesterone receptor signalling and mammary gland morphogenesis, mammary gland stem cells and breast cancer stem cells.
Models PR-A and PR-B transgenic mouse models, LM05 cells lines, M05 mouse mammary tumor
Methods Primary cell cultures, transgenic mice, whole mounts, flow citometry, confocal microscopy, TIRF, stem cell culture, protein biochemistry, etc.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, April 2, 2013
 
Last name SLEEMAN
First name JONATHAN
Institution University of Heidelberg, Medical Faculty Mannheim, Ludolf-Krehl-Str 13-17, 68167 Mannheim, Germany and Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, 76021 Karlsruhe, Germany
Country
Phone +49 621 383 9955
E-mail sleeman@medma.uni-heidelberg.de
Website http://www.ma.uni-heidelberg.de/inst/cbtm/mbio/
Group leader since (year) 1997
Research interests Tumor metastasis, particularly the role of the lymphatic system in tumor dissemination, the role of cancer stem cells in metastasis and the microenvironment that supports metastatic growth
Models Knockout and transgenic mice, transplantable syngeneic and xenograft tumor models, in vitro cell models
Methods Animal technology, standard immunohistochemistry, molecular and cell biology techniques, primary cell culture, FACS sorting, microarray, in vitro metastasis assays, time lapse, cell encapsulation, synthetic organic chemistry, various immunoassays, yeast 2 hybrid, confocal, whole mounts, etc
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name SMALLEY
First name MATT
Institution European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff
Country
Phone +442920875862
E-mail SmalleyMJ@Cardiff.ac.uk
Website http://www.cardiff.ac.uk/research/cancer-stem-cell/contacts-and-people...
Group leader since (year) 2006
Research interests Stem cells in normal and neoplastic mammary epithelium; control of self-renewal and differentiation in mammary stem cells
Models Advanced mouse breast cancer models; primary culture of normal cells
Methods Harvest of primary mouse mammary epithelium; multicolour flow cytomtery; cleared fat pad transplantation; qPCR
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Current lab members: Kirsty Greenow, Howard Kendrick, Huw Morgan, Giusy Tornillo
Last update
Wednesday, May 7, 2014
 
Last name SMITH
First name GILBERT
Institution National Cancer Institute
Country UNITED STATES
Phone 1-0-301-496-2385
E-mail gs4d@nih.gov
Website http://ccr.cancer.gov/staff/staff.asp?profileid=5602
Group leader since (year) 1970
Research interests Mammary gland development, stem cell hierarchy in epithelium, growth senescence, cancer, mutations relevant to mammary epithelial transformation
Models CzechII mice (no MMTV provirus in genome); WAPCre/Rosa26flox-STOP-flox-lacZ model, reprogramming non-mammary cells in mouse mammary glands during outgrowth
Methods Tissue culture Transplantation Microscopy
List of transgenic and KO
mice available
No
Comments
(including wish list)
Not in Europe but happy to connect and collaborate/consult with members of this group...
Last update
Wednesday, January 5, 2011
 
Last name SONNENBERG
First name ARNOUD
Institution The Netherlands Cancer Inst.
Country
Phone 31-20-5121942
E-mail a.sonnenberg@nki.nl
Website
Group leader since (year) 1990
Research interests Role of laminin-binding integrins and associated proteins in mammary gland development, mammary differentiation and tumorigenesis. Hemidesmosomes, integrin signaling, diagnostic markers for mammary gland development and stem cells in normal and neoplastic epithelium
Models Conditional knockout mice for the integrin alpha3 (Iga3), beta4 (Itgb4) and the tetraspanin CD151.
Methods Microscopy, immunohistochemistry, cell culture, protein biochemistry, KO and transgenic mice, etc.
List of transgenic and KO
mice available
No
Comments
(including wish list)
None
Last update
Monday, September 29, 2008
 
Last name SØRLIE
First name THERESE
Institution The Norwegian Radium Hospital Oslo University Hospital
Country NORWAY
Phone +4722781364
E-mail tsorlie@rr-research.no
Website http://www.ous-research.no/sorlie/
Group leader since (year) 2012
Research interests Breast cancer initiation and progression; DCIS; cell of tumor origin; genotype-phenotype interactions
Models PDX; chemically-induced mouse models; GEMMs; humananized mouse models
Methods genome-wide profiling technologies, lineage-tracing;in situ hybridization technoloiges
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, June 22, 2016
 
Last name STEIN
First name TORSTEN
Institution Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Country
Phone +44 (0)141 211 1942
E-mail Torsten.Stein@glasgow.ac.uk
Website http://www.gla.ac.uk/researchinstitutes/cancersciences/staff/torstenst...
Group leader since (year) 2006
Research interests mammary gland development; involution; terminal end buds; breast cancer development. We are trying to identify and characterise novel pathways that are involved or control key stages of mammary gland development, and that may be deregulated in breast cancer. Particular genes of interest: Annexin A8, Reelin, TSC-22.
Models normal mouse; TSC-22D1i2 transgenic mice
Methods microarrays, IF, IHC, standard cell and molecular biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
none
Last update
Wednesday, May 1, 2013
 
Last name STERNECK
First name ESTA
Institution National Cancer Institute
Country UNITED STATES
Phone +1-301-846-1471
E-mail sternecg@mail.nih.gov
Website https://ccr.cancer.gov/esta-sterneck
Group leader since (year) 2003
Research interests We investigate cell signaling pathways that regulate mammary gland development and breast tumorigenesis, with specific focus on the transcription factor CCAAT/enhancer binding protein delta (CEBPD), hypoxia, inflammation, endoplasmic reticiulum stress, cancer stem cells.
Models MMTV-Neu, MMTV-NIC, LysM-Cre, CEBPD ko and floxed, CEBPB ko and floxed
Methods human cell lines, xenografts, PDX, mouse GEM
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Thursday, November 30, 2017
 
Last name STREULI
First name CHARLES
Institution University of Manchester
Country
Phone +44 161 275 5626
E-mail cstreuli@manchester.ac.uk
Website http://www.wellcome-matrix.org/
Group leader since (year) 1991
Research interests mammary gland development and function; integrin signalling mechanisms, small GTPases; extracellular matrix; early breast cancer; circadian clocks; human breast density
Models primary mammary cell cultures; mammary-specific gene deletion in vivo and culture
Methods primary cell culture; 3D culture; 3D immunstaining; gene deletion in vivo with mammary-specific Cre; gene deletion in primary culture with 4-OHT (CreER) or viral infection with shRNA lentiviruses
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, December 17, 2014
 
Last name STYLIANOPOULOS
First name TRIANTAFYLLOS
Institution University of Cyprus
Country CYPRUS
Phone +35722892238
E-mail tstylian@ucy.ac.cy
Website http://www.ucy.ac.cy/cancer_biophysics/en
Group leader since (year) 2010
Research interests drug delivery, tumor microenvironment, tumor normalization strategies, metastasis
Models mathematical models, orthotopic breast and pancreatic tumor models, 3D in vitro models of solid tumors
Methods systemic drug administration, immunofluorescence staining, Real-time PCR, western blotting, tumor spheroids, invasion assays, mechanical testing for tumor stiffness, interstitial fluid pressure measurement, Atomic Force Microscopy
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Tuesday, July 4, 2017
 
Last name SWARBRICK
First name ALEX
Institution Garvan Institute of Medical Research
Country AUSTRALIA
Phone +61-2-9295-8366
E-mail alex.swarbrick@gmail.com
Website http://www.garvan.org.au/about-us/our-people/dr-alex-swarbrick
Group leader since (year) 2007
Research interests Stem cell pathways in mammary development, breast cancer and metastatic progression. MicroRNAs in cancer progression. Inhibitor of Differentiation proteins, Id1, Id2, Id3, Id4 Hedgehog pathway in breast cancer. Development of novel therapeutics / biomarkers for therapeutic response to existing agents
Models Chimeric (transplant) Mouse models of mammary development and cancer. ID1- and ID4- GFP knock-in mice. LSL-SmoM2 and Ptc-LacZ knockin mice. C3-SV40 Large T transgenic. Cell lines in vivo: Comma-d-b, 4T1, M6, MDA-MB-231
Methods In vivo and in vitro stem and progenitor assays. In vivo imaging. Inducible gene expression and knockdown
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Monday, November 29, 2010
 
Last name TSCHAN
First name MARIO P.
Institution Experimental Pathology, TP2, University of Bern
Country SWITZERLAND
Phone +41 31 632 8780
E-mail mario.tschan@pathology.unibe.ch
Website http://www.pathology.unibe.ch/content/forschung/experimental_pathology...
Group leader since (year) 2005
Research interests Autophagy (Autophagic Pathways in Myeloid Development and Resistance Mechanisms), Resistance Mechanisms in Targeted Cancer Therapies (Breast and Lung Cancer, Acute Myeloid Leukemias), Retinoid Acid Therapy, Apoptosis, Transcription Factors and microRNAs Regulating ATG Genes and Genes involved in AML Differentiation/Cell Survival
Models Human Breast Cancer Cell Line Models, Breast Cancer Patient Samples (TMA), Mammospheres, Establishing 3D Perfusion Reactor for Breast Cancer (Cell Lines and Primary Tissue)
Methods Lentiviral vectors (KD, overexpression, constitutive/inducible), Autophagy detection (GFP-RFP-LC3B tandem constructs, long-lived protein degradation analysis, endogenous LC3B detection in Cells and FFPE tissue,...), AML and Breast Cancer Cell Line Models, Tissue Micro Arrays, Proximity Ligation Assays, Promoter Reporter and ChIP assays, FACS, RNA and Protein Analyses
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, September 1, 2015
 
Last name TWIGGER
First name ALECIA-JANE
Institution Hartmann Human Lactation Research Group, The University of Western Australia
Country AUSTRALIA
Phone +61 477 095 552
E-mail aleciajane.twigger@gmail.com
Website http://humanlactationresearchgroup.com/the-group/
Group leader since (year)
Research interests Breastmilk cells, mammary gland development and maturation, breast cancer, lactation, mammary cell differentiation, mammary and breastmilk stem cells, breastfeeding difficulties, trophic factors, breastmilk constituents, aberrant breast growth, mammary transcriptome
Models
Methods Breastmilk cell, breast cancer and hESC 2D and 3D culture, RT-PCR, RNA-Seq, flow cytometry, western blotting, ELISAs, cell differentiation, breastmilk analysis
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, December 21, 2015
 
Last name UCAR
First name AHMET
Institution University of Manchester
Country UNITED KINGDOM
Phone +44-161-3067116
E-mail ahmet.ucar@manchester.ac.uk
Website http://www.breastcentre.manchester.ac.uk/Research-Groups/Ahmet-Ucar
Group leader since (year) 2017
Research interests Mammary gland development and function, breast tumourigenesis, Rac signalling, Mammary epithelial stem cells, and breast cancer stem cells.
Models Genetically modified mouse models, primary cell culture, and established breast cancer cell lines
Methods Whole mount staining, histology, Flow cytometry analyses, genetic modification via lentivviral transduction, cleared fat pad transplantation, whole-breast transplantation
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, August 25, 2017
 
Last name UMAR
First name ARZU
Institution Erasmus University Medical Center Rotterdam
Country NETHERLANDS
Phone +31107044373
E-mail a.umar@erasmusmc.nl
Website http://www.erasmusmc.nl/47454/51019/696357/829175/research-umar
Group leader since (year) 2009
Research interests Breast cancer proteomics biomarker discovery therapy resistance functional proteomics protein-protein interactions cancer cell - T-cell interactions anti-cancer immune response
Models cell lines
Methods laser capture microdissction nanoscale liquid chromatography high resolution mass spectrometry in situ proximity ligation assay co-cultures FACS Western Blot immunohistochemistry
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, April 2, 2013
 
Last name VAN AMERONGEN
First name RENEE
Institution University of Amsterdam
Country NETHERLANDS
Phone +31-20-5255682
E-mail r.vanamerongen@uva.nl
Website http://www.vanamerongenlab.nl
Group leader since (year) 2013
Research interests Wnt signalling, mammary gland biology, breast cancer, stem cells
Models Cre/lox mediated lineage tracing: Axin2-CreERT2 // mTmG // Confetti; Doxycycline inducible models: tetO-Wnt5A // R26rtTA
Methods 3D primary organoid cultures, in vivo lineage tracing, FACS sorting, CRISPR editing, functional imaging (FCS)
List of transgenic and KO
mice available
No
Comments
(including wish list)
The goal of my lab is to understand how Wnt signaling controls mammary gland development and function at the molecular, cell and tissue level. To this end, we have established an experimental pipeline that allows us to probe the role of Wnt signaling in mammary gland development and breast cancer "from mouse to molecule". This includes analyses at the DNA/RNA level (RNAseq/CHIPseq), CRISPR genome editing in cells (in combination with advanced microscopy analysis such as fluorescence correlation spectroscopy), primary 3D organoid cultures, cell sorting, fat pad transplantation assays and complex mouse models for in situ analysis of mammary stem cells. All of this is built on a strong basis in Wnt-signal transduction, with expertise in both beta-catenin dependendent and -independent signalling.
Last update
Thursday, December 1, 2016
 
Last name VAN DE WATER
First name BOB
Institution Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
Country
Phone 31 71-5276223
E-mail b.water@lacdr.leidenuniv.nl
Website
Group leader since (year) 1999
Research interests Role of cell-ECM signaling in mammary gland development and breast cancer development and progression/metastasis. Integrated signaling between receptor protein tyrosine kinase and focal adhesion kinase (FAK). FAK-mediated signaling.
Models Conditional knockouts for FAK and p53. Mammary gland reconstitution models. Orthotopic breast tumor/metastasis models. 2D and 3D migration/invasion models. 3D branching morphogenesis models. Models for focal adhesion dynamics.
Methods siRNA and shRNA libraries. Retro- and lenti-viral transduction of MMEC and breast tumor cell lines. 2D and 3D MEC cultures. Live cell imaging (spectral imaging, TIRF microscopy, confocal, DIC) followed by quantitative image analysis. Fluorescence and bioluminescence analysis of breast cancer progression. Conditional expression of DN and DA target genes in orthotopic breast tumor models. Intravital imaging of breast tumor cell migration in primary tumor. Gene expression profilling.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name VAN LOHUIZEN
First name MAARTEN
Institution The Netherlands Cancer Institute
Country
Phone +31-20-5122030
E-mail m.v.lohuizen@nki.nl
Website http://research.nki.nl/lohuizenlab/
Group leader since (year) 1995
Research interests We study epigenetic gene regulation and transcriptional repression by Polycomb-group (Pc-G) protein complexes, and the effects of deregulation of Pc-G genes on development, Cell cycle control, cancer formation and stem cell maintenance. In addition, we are performing large-scale genetic screens in primary cells and in cancer-predisposed mice to identify cancer-relevant combinations of collaborating oncogenes and tumor-suppressor genes.
Models Diverse animal models: Bmi1 KO and conditional KO mice; EZH2 conditional KO mice, RNF2 conditional KO mice;Tissue-specific inducible Bmi1 transgenic mice;MMTV-Wnt1; MMTV-NEU; MMTV-Myc;
Methods mouse and human ES cell technologies, fat pad transplantation, 2D MEC culture, protein biochemistry, high content screening, lentiviral or retroviral transduction, stem cell FACS sorting, DAMid chromatin profiling, High throughput in vivo retroviral insertional mutagenesis screens
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name VAN RHEENEN
First name JACCO
Institution Hubrecht Institute
Country NETHERLANDS
Phone +31 (0)30-2121905
E-mail j.vanrheenen@hubrecht.eu
Website http://www.niob.knaw.nl/research/vanrheenen/index.html
Group leader since (year) 2008
Research interests Complication of metastasis, the process in which cells detach from the primary tumor to form new distant tumor sites, is the primary reason why women die from breast cancer. The metastatic behavior of tumor cells is highly dependent on the cell’s intrinsic characteristics and on the tumor microenvironment, such as stromal cells and the extracellular matrix. We study both by combining conditional mouse models that recapitulate human breast tumors and intravital imaging techniques (high resolution imaging of metastasis in living animals in real time). By these experiments we hope to indentify new drug targets that combined with current clinical approaches may lead to new therapies.
Models allograft tumor models:1) Ola/FVB mice with Kep1_11 cells (Cdh-/-;Trp53-/-, Derksen et al, Canc Cell 2004)2) BalbC with 4T1 cell line. Genetic model:MMTV-Neu tumor model
Methods Our lab studies the behavior of metastasizing tumor cells inside living mice by intravital imaging; the imaging of living tissue. Whole mice bearing metastasizing tumors are imaged at subcellular resolution by confocal or two-photon microscopy. Our lab, together with the labs of Drs Segall and Condeelis (Albert Einstein College of Medicine, Bronx, NY, USA) has developed a mammary gland imaging window in order to image and track cells for multiple days inside mammary tumors in living mice. Moreover, we use intravital FRET imaging to study activity of several signaling pathways inside metastasizing tumor cells.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name VANHAESEBROECK
First name BART
Institution Centre for Cell Signalling - Institute of Cancer - Barts and the London Medical School -
Country
Phone 00-44-207-882-8201
E-mail bart.vanh@qmul.ac.uk
Website http://www.cancer.qmul.ac.uk/research/cell_signalling/
Group leader since (year) 1998
Research interests Signal transduction - cancer and inflammation
Models mouse models - knock-in gene-targeting - PI 3-kinase and related pathways
Methods standard cell and molecular biology - biochemistry - mass spectrometry
List of transgenic and KO
mice available
No
Comments
(including wish list)
special interest in cancer and inflammation, in relation to breast cancer
Last update
Monday, September 29, 2008
 
Last name VENEZIANI
First name BIANCA MARIA
Institution Dipartimento di Medicina Molecolare e Biotecnologie Mediche Scuola di Medicina e Chirurgia Università di Napoli "Federico II"
Country ITALY
Phone 390817463758
E-mail bianca.veneziani@unina.it
Website http://dmmbm.dip.unina.it/
Group leader since (year) 2000
Research interests Human breast cancer, steroid receptors, signalling and stem cells. Mechanisms of resistance to current treatments. Stromal and adipose tissue of the mammary gland.
Models Breast cancer epithelial-stromal co-cultures, mammospheres.
Methods Primary cell culture, breast cancer cell lines, in vitro analysis of the tumor-stroma interaction, cryopreservation, qPCR, FACS, stem cell sorting, RNA and protein analyses.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, December 2, 2013
 
Last name VIVANCO
First name MARIA
Institution CIC bioGUNE, Cell Biology and Stem Cells Unit, Bilbao, SPAIN
Country
Phone +34 94 406 1322
E-mail mdmvivanco@cicbiogune.es
Website http://www.cicbiogune.es/
Group leader since (year) 1997
Research interests Steroid hormone receptors, transcription and cell signalling, mechanisms of resistance to therapy, human mammary gland, breast cancer, normal and cancer stem cells, regulation of self-renewal and differentiation in human breast stem cells
Models human mammary epithelial cells (normal and tumour)
Methods human mammary primary cultures, 2D and 3D cultures, FACS, qPCR, multiplex RT-PCR, confocal microscopy, general molecular and cellular biology techniques
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Friday, May 3, 2013
 
Last name VON EYSS
First name BJOERN
Institution Leibniz Institute on Aging - Fritz Lipmann Institute
Country GERMANY
Phone + 49 (0) 3641-65-6047
E-mail bjoern.voneyss@leibniz-fli.de
Website http://www.leibniz-fli.de/research/research-groups/von-eyss/
Group leader since (year) 2016
Research interests Hippo Signalling Breast Cancer Lineage Commitment
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, November 16, 2016
 
Last name WAKEFIELD
First name LALAGE
Institution National Cancer Institute
Country UNITED STATES
Phone +1-301-496-8351
E-mail lw34g@nih.gov
Website http://ccr.cancer.gov/staff/staff.asp?profileid=13665
Group leader since (year) 1989
Research interests TGF-beta pathway in mammary gland development and neoplasia. Development of TGF-beta path targeted therapeutics. Metastasis. Breast cancer stem cells.
Models Human xenograft, mouse syngeneic transplant, genetically engineered mouse breast cancer models
Methods Transcriptomics, Chip-Chip/Seq, RNAi, confocal microscopy, transgenesis, ex vivo metastasis assays, immunophenotyping, techniques for quantitative analysis of TGF-beta pathway
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, November 11, 2010
 
Last name WATSON
First name CHRISTINE
Institution University of cambridge
Country
Phone +44 1223 333725
E-mail cjw53@cam.ac.uk
Website http://www.path.cam.ac.uk~madgroup
Group leader since (year)
Research interests
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name WESTERMARCK
First name JUKKA
Institution Centre for Biotechnology, University of Turku
Country FINLAND
Phone +35823338621
E-mail jukwes@utu.fi
Website http://www.btk.fi/research/research-groups/westermarck/
Group leader since (year) 2002
Research interests Breast cancer, therapy resistance, patient stratification, basal-like breast cancer, Her2, Protein Phosphatase 2A (PP2A), CIP2A, MYC, RAS, phosphoproteomics, phosphorylation dependent signalling
Models Cell culture, mammospheres, CIP2A knock-out mouse models, xenografts
Methods MS proteomics, RNA sequencing, Tissue microarrays, drug response screens, RNAi, viral gene transduction, western blot, systems biology
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Sunday, January 3, 2016
 
Last name WHITELAW
First name BRUCE
Institution Roslin Institute and Royal (Dick) School of Veterinary Studies Univeristy fo Edinburgh Roslin Midlothian EH25 9PS, UK
Country
Phone +44-(0)131-527-4200
E-mail bruce.whitelaw@rolsin.ed.ac.uk
Website
Group leader since (year) 1994
Research interests gene transfer gene expression systems cancer stem cell biology mammary growth and development
Models transgenic mice transgenic sheep and pigs
Methods general molecular biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Monday, September 29, 2008
 
Last name WIESMÜLLER
First name LISA
Institution Gynaecological Oncology, Head Department of Obstetrics and Gynaecology of the University of Ulm
Country GERMANY
Phone +49-(0)731-500-58800/58801
E-mail lisa.wiesmueller@uni-ulm.de
Website http://www.uni-ulm.de/klinik/ufk/cms/html/forschung_gyn-onko.htm
Group leader since (year) 2001
Research interests apoptosis breast cancer risk chemoprevention DNA double strand break repair homologous recombination replication fork stalling prediction of therapeutic responsiveness
Models - patient cell lines - peripheral lymphocytes, fibroblasts, and primary epithelial cells from mammary gland of probands/patients - MEFs from mice differing in breast cancer susceptibilities
Methods - analysis of distinct DNA double strand repair pathways - nuclear foci analysis for DNA damage/repair factors - apoptosis analyses - characterization of genotoxic, chemopreventive, and therapeutic agents agents
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Wednesday, January 5, 2011
 
Last name WOOD
First name TERRI
Institution New Jersey Medical School Cancer Center/Rutgers Biomedical & Health Sciences
Country UNITED STATES
Phone 973-972-6529
E-mail terri.wood@rutgers.edu
Website http://njmsuhcc.umdnj.edu/home/index.php/Wood-Lab.html
Group leader since (year) 1993
Research interests Mammary/breast development and cancer, insulin-like growth factors, stem cells, signaling pathways
Models Transgenic/KO mice, in vitro non-adherent mammospheres
Methods sphere limiting dilution assay
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, May 1, 2014
 
Last name YOUNG
First name LEONIE
Institution Royal College of Surgeons in Ireland
Country IRELAND
Phone +35314028576
E-mail lyoung@rcsi.ie
Website http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=35&pip=pubs#t...
Group leader since (year) 2001
Research interests - Coactivator proteins in endocrine-resistant breast cancer - Identification of biomarkers to predict endocrine-sensitivity and endocrine-resistance in breast cancer patients
Models Breast cancer patient primary cultures Tissue microarrays Murine tumour models
Methods Immunohistochemistry In situ FRET CHIP-Seq Transcription factor binding
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Last update
Thursday, November 5, 2009
 
Last name ZARAGOZÁ
First name ROSA
Institution University of Valencia
Country SPAIN
Phone +34963864187
E-mail rosa.zaragoza@uv.es
Website
Group leader since (year)
Research interests Mammary gland involution; pregnancy-associated breast cancer; Calpains; intracellular signaling pathways
Models cell lines, mouse models: KO and transgenic mice.
Methods Microarrays; confocal microscopy: Proteomics; Western blot, immunoprecipitation, transfection, siRNA; Adhesion and migration assays,
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Tuesday, January 30, 2018
 
Last name ZHANG
First name XIANG
Institution Baylor College of Medicine
Country UNITED STATES
Phone 7137986239
E-mail xiangz@bcm.edu
Website https://www.bcm.edu/research/labs/xiang-zhang
Group leader since (year) 2011
Research interests Tumor microenvironment, metastasis, bone metastasis, metastasis model development, tumor immunology, immunotherapy, breast cancer.
Models Genetically engineered mouse models, patient-derived xenografts, human and murine cancer cell lines.
Methods Orthotopic tumor transplantation, intra-vascular injection-based metastatic colonization assays, 2D and 3D co-culturing of cancer cells and other cells, immune cell profiling, Omics.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Welcome opportunities of collaboration.
Last update
Wednesday, December 14, 2016
 
Last name ZIPPO
First name ALESSIO
Institution CIBIO, University of Trento
Country ITALY
Phone 00390461283735
E-mail alessio.zippo@unitn.it
Website https://www.cibio.unitn.it/675/laboratory-of-chromatin-biology-epigene...
Group leader since (year) 2013
Research interests Breast cancer, cancer stem cells, gene expression control, epigenetics, autoimmunity, cancer reprogramming, Tumor Heterogeneity, Metastasis
Models ex-vivo culture models, organoids, xenografts.
Methods Live cell imaging, confocal, super-resolution microscopy, ChIP-seq, ATAC-seq, RNA-seq, CRISPR/Cas9 systems
List of transgenic and KO
mice available
No
Comments
(including wish list)
Last update
Thursday, November 8, 2018