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EUROPEAN NETWORK OF BREAST DEVELOPMENT AND CANCER LABS
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| LIST OF EUROPEAN LABS WORKING IN THIS RESEARCH AREA: |
| Last name |
BENTIRES-ALJ
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| First name |
MOHAMED (MOMO) |
| Institution |
Friedrich Miescher Institute for Biomedical Research (FMI) |
| Country |
SWITZERLAND |
| Phone |
+ 41 (0) 61 69 74048 |
| E-mail |
Bentires@fmi.ch |
| Website |
http://www.fmi.ch/bentires-alj.m
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| Group leader since (year) |
2006 |
| Research interests |
Breast development and cancer, protein tyrosine phosphatases, epithelial-stroma interactions, stem cells, 11q13 amplification, signaling |
| Models |
3D cultures, ex vivo culture models (HMECs...), xenograft, KO and transgenic mice, humanized mouse |
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
none |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, January 08, 2009 |
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| |
| Last name |
BIRNBAUM
|
| First name |
DANIEL |
| Institution |
Centre de Recherche en Cancérologie de Marseille, UMR599 Inserm and Institut Paoli-Calmettes |
| Country |
|
| Phone |
33 4 91 75 84 07 |
| E-mail |
birnbaum@marseille.inserm.fr |
| Website |
http://crcm-en.marseille.inserm.fr/
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| Group leader since (year) |
1987 |
| Research interests |
Molecular Oncology, Oncogenomics, Breast cancer, Leukemia, Colon cancer, Tyrosine kinases, Oncogenes, Prognosis markers, Mitosis, Centrosome. |
| Models |
Human pathologies, cell lines, mouse models. |
| Methods |
DNA microarrays, array-CGH, FISH, sequencing, tissue microarrays, videomicroscopy, confocal microscopy, transgenesis, xenografts. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, September 29, 2008 |
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| Last name |
BONIZZI
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| First name |
GIUSEPPINA (GIUSY) |
| Institution |
European oncology institute (IEO) |
| Country |
|
| Phone |
+390257489396 |
| E-mail |
giuseppina.bonizzi@ifom-ieo-campus.it |
| Website |
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| Group leader since (year) |
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| Research interests |
Breast Stem cell and Breast cancer stem cell |
| Models |
3D cultures, xenograft, KO and transgenic mice, humanized mouse |
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
none |
Mailing list
(managed by webmaster) |
Yes
|
Last update
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Monday, August 25, 2008 |
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| Last name |
BØRRESEN-DALE
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| First name |
ANNE-LISE |
| Institution |
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet |
| Country |
|
| Phone |
+47 22 78 13 73 |
| E-mail |
a.l.borresen-dale@medisin.uio.no |
| Website |
http://www.radium.no/genetics/
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| Group leader since (year) |
>20 years |
| Research interests |
The Department's Research vision is exploring The Systems Biology of Breast Cancer Our research program is focusing on the molecular biology of breast and ovarian cancer with emphasis on identification of genotypes and gene expression profiles contributing to elevated cancer risk, radiation sensitivity, tumor aggressiveness and therapy resistance. The hypothesis is that both the geno- and phenotype of the tumor as well as the patients own genotype (the genetic “makeup” of the patient constituted by both high and low penetrance genes) play a role in breast and ovarian cancer risk, in the type of cancer developed, the disease course and the response to treatment. The results may be used to identify high-risk individuals that may benefit from preventing strategies, and to individualize the treatment of patients with respect to choice of drugs as well as to dose and duration. This may give a better therapeutic effect and less adverse reactions in the individual patient. Goals: 1. To join forces and expertise to create a world-leading Breast Cancer Research Center including The Dept of Medical Statistic Faculty of Medicine, Dept of Informatics, Faculty of Mathematics and Natural Sciences, UiO, The Norwegian Radium Hospital, Ullevål Univ. Hospital and potentially other hospitals in the Oslo area 2. To follow the linear time course of predisposition, initiation, early stages and advanced disease and to dissect the molecular mechanisms triggered at each stage 3. To follow the multidimentional interactions at various levels in a systems biology approach |
| Models |
large cohorts of breast cancer patients with long term follow up, and healty woman participating in a population based study NOWAC http://uit.no/kk/NOWAC/ |
| Methods |
large scale analyses using various array technology to perform WGA on SNPs and CNVc, blood expression (mRNA and miRNA), Tumor mRNA and miRNA expression, aCGH, mutation, methylation and protein anaalyses using RPPA |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Tuesday, July 20, 2010 |
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| |
| Last name |
BRACKE
|
| First name |
MARC |
| Institution |
Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. |
| Country |
|
| Phone |
+32 9 332 3007 |
| E-mail |
brackemarc@hotmail.com |
| Website |
http://www.ugent.be/people?ugentid=801000436153
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| Group leader since (year) |
2003 |
| Research interests |
Mechanisms of tumor invasion and metastasis, mammary cancer, stromal interactions with cancer cells (myofibroblasts, adipocytes and stem cells), cytoskeleton and motility, cadherin/catenin complexes in cell-cell adhesion, endoplasmic reticulum stress, radiation-induced effects on invasion, new circulating tumor markers, invasion suppressor genes, early metastasis genes, hormones and breast cancer. |
| Models |
3D-models for invasion in vitro (embryonic chick heart, type I collagen, Matrigel, reconstituted tissues), metastasis models in laboratory mice, aggregation models for cell-cell adhesion, interaction models between stromal and cancer cells, directional migration models (wound healing, checker board analysis, radial aggregate outgrowth). |
| Methods |
Organotypic confronting cultures for invasion, Western blot, immunoprecipitation, transfection, siRNA, time-lapse microscopy, immunohisto/cytochemistry, raising monoclonal antibodies, ELISA, assays for ER stress and apoptosis, cell irradiation, PCR… |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, September 29, 2008 |
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| |
| Last name |
BRAGA
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| First name |
VANIA |
| Institution |
Molecular Medicine, NHLI, Faculty of Medicine
Imperial College London |
| Country |
|
| Phone |
+44 20 7594-3233 |
| E-mail |
v.braga@imperial.ac.uk |
| Website |
|
| Group leader since (year) |
1996 |
| Research interests |
epithelial polarization and differentiation, signalling from cell-cell adhesion receptors, small GTPases, cell-cell adhesion, cadherin receptors, morphological transformation, cancer cell biology |
| Models |
primary cultures of keratinocytes, cell lines |
| Methods |
microinjection, microscopy, RNAi, RNAi screen, protein-protein interaction, cell-cell adhesion assays, yeast two-hybrid, Q-PCR. intracellular trafficking assays |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
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| Last name |
BRISKEN
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| First name |
CATHRIN |
| Institution |
Swiss Institute for Experimental Cancer Research (ISREC)
School of Life Sciences
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
| Country |
SWITZERLAND |
| Phone |
41-21-6925851 |
| E-mail |
cathrin.brisken@epfl.ch |
| Website |
http://www.nccr-oncology.ch/scripts/index.aspx?idd=85
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| Group leader since (year) |
2001 |
| Research interests |
Mammary gland development, breast cancer, hormone action, intercellular communication, morphogenesis |
| Models |
mouse mutant strains,
primary human breast epithelial cells |
| Methods |
tissue recombinations techniques, primary cultures of mouse and human breast epithelial cells, retro and lentiviral infections |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Sunday, January 11, 2009 |
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| Last name |
BUESS
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| First name |
MARTIN |
| Institution |
Department of Research |
| Country |
|
| Phone |
0041 61 265 50 74 |
| E-mail |
mbuess@uhbs.ch |
| Website |
|
| Group leader since (year) |
2005 |
| Research interests |
Understanding the pathophysiology of breast cancer gene expression profiles by in vitro analysis of the tumor-stroma interaction |
| Models |
|
| Methods |
primary cell culture, breast cancer cell lines, qPCR, HEEBO microarrays, FACS, standard molecular and cell biology techniques |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
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| |
| Last name |
CALDAS
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| First name |
CARLOS |
| Institution |
Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge |
| Country |
|
| Phone |
+44(0)1223 404420 |
| E-mail |
cc234@cam.ac.uk |
| Website |
http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/caldasc/...
|
| Group leader since (year) |
1997 |
| Research interests |
Breast cancer
Genomics
Cancer stem cells
microRNA
Oncogenes and tumor supressor genes
8p12 |
| Models |
Cell lines
Human breast cancers
Mouse models |
| Methods |
Expression microarrays
Array-CGH
Bioinformatics
Tissue microarrays
Xenografts
Mammosphere assay |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
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| |
| Last name |
CHARIOT
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| First name |
ALAIN |
| Institution |
Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry Unit, University of Liege, Belgium |
| Country |
|
| Phone |
32 4 366 24 72 |
| E-mail |
alain.chariot@ulg.ac.be |
| Website |
http://www.chimmed.ulg.ac.be
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| Group leader since (year) |
2005 |
| Research interests |
Insight into the NF-kB and IRF-activating signaling pathways: Elucidation of the TBK1/IKKe-dependent cascades in vivo. Insight into their deregulations in breast cancer. |
| Models |
We are currently generating a transgenic model for IKKe |
| Methods |
Yeast-two hybrid, micro-array analyses, ChIP assays, kinase assays, IPs, Real-time PCRs. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
We are interested in exploring the oncogenic potential of two kinases, TBK1 and IKKe, by extending our knowledge from the molecular level to an in vivo model. |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
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| |
| Last name |
CINTI
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| First name |
SAVERIO |
| Institution |
Section of Anatomy, Dept. of Molecular Patholgy and Innovative Therapies, School of Medicine, University of Ancona (Politecnica delle Marche), Ancona, Italy |
| Country |
|
| Phone |
+39 0712206088 |
| E-mail |
cinti@univpm.it |
| Website |
http://www.univpm.it/Entra/Engine/RAServePG.php/P/320710012049/idsel/3...
|
| Group leader since (year) |
>20 |
| Research interests |
Adipose organ. Adipose tissue of the mammary gland. Interaction between epithelial cells in mammary gland and adipocytes. White adipose tissue. Brown adipose tissue. Transdifferentiation. |
| Models |
|
| Methods |
Light microscopy. Immunohistochemistry. Immunocytochemistry. Confocal microscopy. Electron microscopy. LacZ and GFP mice. Morphometry. Micro-dissection. Whole mount tissue embedding, adipose cell culture |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
Our data support the reversible transdifferentiation of milk secretory epithelial cells into adipocytes in the mammary gland. PNAS, 101, 48, 16801-16806, 2004; In vivo physiological transdifferentiation of adult adipose cells, De Matteis R, Zingaretti MC, Murano I, Vitali A, Frontini A, Giannulis I, Barbatelli G, Marcucci F, Bordicchia M, Sarzani R, Raviola E, Cinti S, Stem Cells. 2009 Nov;27(11):2761-8. |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, May 06, 2010 |
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| |
| Last name |
CLARKE
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| First name |
ROB |
| Institution |
University of Manchester |
| Country |
|
| Phone |
44-(0)161-446 3210 |
| E-mail |
robert.clarke@manchester.ac.uk |
| Website |
http://www.breastcentre.manchester.ac.uk/
|
| Group leader since (year) |
2003 |
| Research interests |
Human breast cancer, normal breast tissue, steroid receptors, signalling and stem cells |
| Models |
Primary human breast tissue xenografts and 3D breast cell culture: matrigel and mammospheres |
| Methods |
FACS and MACS for stem cell enrichment. RNA and protein analyses. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
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| |
| Last name |
CLARKSON
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| First name |
RICHARD |
| Institution |
University of Cardiff School of Biosciences |
| Country |
|
| Phone |
+2920 870249 |
| E-mail |
clarksonr@cf.ac.uk |
| Website |
http://www.cardiff.ac.uk/biosi/research/genetics/index.html
|
| Group leader since (year) |
2005 |
| Research interests |
involution, apoptosis, programmed cell death, transcription factors, signaling, development, cancer |
| Models |
mouse and human, normal and cancer cell lines
mouse primary cell culture
conditional KO and conditional transgenics
mouse transgenic models of BC |
| Methods |
chIP, microarrays, MRI, transgenesis, QPCR, immunodetection |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
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| |
| Last name |
COOMBES
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| First name |
R CHARLES |
| Institution |
Imperial College |
| Country |
|
| Phone |
020 8383 5828 |
| E-mail |
c.coombes@imperial.ac.uk |
| Website |
http://www.imperial.ac.uk/medicine/sora
|
| Group leader since (year) |
20+ |
| Research interests |
I run a laboratory of approximately 200 staff in which we are engaged in the development of new forms of treatment for breast cancer, particularly endocrine therapy. Over the past 20 years, my group has completed the clinical development of two steroidal aromatase inhibitors, including 4-hydroxyandrostenedione and exemestane and my laboratory is currently engaged in studies aimed at understanding the role of estrogen receptor a and estrogen receptor ß in human breast cancer.
We are engaged in developing novel methods for prediction of response to endocrine therapy and also doing research aimed at understanding the mechanisms of resistance to endocrine therapy. |
| Models |
|
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, August 25, 2008 |
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| |
| Last name |
DALE
|
| First name |
TREVOR |
| Institution |
Cardiff University |
| Country |
|
| Phone |
+44 29 2087 4652 |
| E-mail |
daletc@cardiff.ac.uk |
| Website |
http://www.cardiff.ac.uk/biosi/contactsandpeople/stafflist/a-d/dale-tr...
|
| Group leader since (year) |
1992 |
| Research interests |
Wnt signalling, stem cells, drug discovery, biochemistry of Wnt signalling protein complexes, signalling pathway networks. |
| Models |
gene targetted mice (knock-out and transgenic) for components of the Wnt pathway. GFP and luciferase reporter readouts for Wnt pathway activity. |
| Methods |
ES cell technologies, fat pad transplantation, protein biochemistry, high content screening |
List of transgenic and KO
mice available |
Yes
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, May 24, 2010 |
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| Last name |
DERKSEN
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| First name |
PATRICK |
| Institution |
University Medical Center Utrecht / Medical Oncology / Lab. of Experimental Oncology |
| Country |
|
| Phone |
+31 88 75 68068 |
| E-mail |
p.w.b.derksen@umcutrecht.nl |
| Website |
http://www.umcutrecht.nl/subsite/oncology/Research-groups/Derksen
|
| Group leader since (year) |
2007 |
| Research interests |
Mouse Models; Mammary gland development and cancer; Metastasis |
| Models |
Human ILC and IDC cell lines; Conditional Mouse Models of ILC |
| Methods |
Orthotopic transplantations; lentiviral transductions; In vivo imaging |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Tuesday, December 01, 2009 |
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| |
| Last name |
DEVILEE
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| First name |
PETER |
| Institution |
Leiden University Medical Center |
| Country |
|
| Phone |
+31 71 526 9510 |
| E-mail |
p.devilee@lumc.nl |
| Website |
http://www.lumc.nl
|
| Group leader since (year) |
1992 |
| Research interests |
Breast cancer susceptibility, somatic genetics, aneuploidy, loss of heterozygosity, genetical genomics |
| Models |
Brca1 conditional KO, human breast cancer families, breast cancer populations |
| Methods |
SNP genotyping, large scale sequencing, gene expression analysis |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
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| |
| Last name |
DI FIORE
|
| First name |
PIER PAOLO |
| Institution |
FIRC Institute of Molecular Oncology (IFOM) Foundation, Via Adamello 16, Milano, Italy |
| Country |
|
| Phone |
+39 02 574303257 |
| E-mail |
pierpaolo.difiore@ifom-ieo-campus.it |
| Website |
http://www.ifom-ieo-campus.it/
|
| Group leader since (year) |
1987 |
| Research interests |
1. Transformation by growth factor and growth factor receptor molecules as a tool to study the normal pathways regulating cell growth and their alteration in the neoplastic process.
2. Mechanisms of mitogenic signal transduction and attenuation by growth factor receptors under normal and neoplastic conditions.
3. Breast stem cell biology |
| Models |
|
| Methods |
DNA microarrays, tissue microarrays, primary cell culture, 3D breast cell culture, protein biochemistry, |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
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| |
| Last name |
DONTU
|
| First name |
GABRIELA |
| Institution |
King's College iLondon |
| Country |
UNITED KINGDOM |
| Phone |
44(0)2071883027 |
| E-mail |
gabriela.dontu@kcl.ac.uk |
| Website |
|
| Group leader since (year) |
2009 |
| Research interests |
mammary stem cells
normal breast development
breast cancer stem cells |
| Models |
|
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Wednesday, May 13, 2009 |
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| |
| Last name |
EDWARDS
|
| First name |
PAUL |
| Institution |
Department of Pathology and Hutchison-MRC Research Institute, University of Cambridge |
| Country |
|
| Phone |
+44 1223 763338 |
| E-mail |
pawe1@cam.ac.uk |
| Website |
http://www.path.cam.ac.uk/pages/edwards/
|
| Group leader since (year) |
1977 |
| Research interests |
Genomics of breast cancer, particularly chromosome translocations. Currently (2007) engaged in comprehensive analysis of translocation breakpoints in breast cancer cell lines, collecting fusion genes.
Previous interest was development of normal and neoplastic mammary gland, particularly using genetic manipulation of gland by transplantation. |
| Models |
|
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, December 21, 2009 |
|
|
| |
| Last name |
FERBY
|
| First name |
INGVAR |
| Institution |
University College London (UCL) |
| Country |
|
| Phone |
+44 (0)20 7679 6293 |
| E-mail |
i.ferby@ucl.ac.uk |
| Website |
http://www.ucl.ac.uk/wibr/research/cancer/if
|
| Group leader since (year) |
2006 |
| Research interests |
Spatiotemporal control of ErbB receptor signalling in mammary gland development and carcinogenesis |
| Models |
Knockout and transgenic mouse models. |
| Methods |
General molecular cell biology, protein biochemistry and primary cell culture. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
FLINT
|
| First name |
DAVID |
| Institution |
Strathclyde University |
| Country |
|
| Phone |
+44 141 548 2693 |
| E-mail |
david.flint@strath.ac.uk |
| Website |
http://www.strath.ac.uk
|
| Group leader since (year) |
20+ |
| Research interests |
insulin-like growth factors, EMT |
| Models |
3D co-culture approaches |
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, August 25, 2008 |
|
|
| |
| Last name |
GALLAGHER
|
| First name |
WILLIAM |
| Institution |
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland |
| Country |
|
| Phone |
+353-1-7166743 |
| E-mail |
william.gallagher@ucd.ie |
| Website |
http://www.ucd.ie/conway/cv_188.html
|
| Group leader since (year) |
1999 |
| Research interests |
(1) Systematic approaches to cancer biology, (2) Molecular basis of tumour progression, particularly metastasis, (3) Cancer biomarker discovery/validation, (4) Breast cancer and melanoma |
| Models |
Isogenic cell culture models, in vivo models, particularly xenograft (syngenic/orthotopic) |
| Methods |
Transcriptomics, proteomics, tissue microarrays, RNA interference, lentiviral transduction, non-invasive in vivo imaging (bioluminescence/biofluorescence, PET/CT) |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
GEE
|
| First name |
JULIA |
| Institution |
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, UK |
| Country |
|
| Phone |
+44 29 20875226 |
| E-mail |
gee@cardiff.ac.uk |
| Website |
http://www.cf.ac.uk/phrmy/researchcentres/Tenovus/index.html
|
| Group leader since (year) |
2000 |
| Research interests |
Historically the Tenovus Centre for Cancer Research has undertaken research in the area of anti-hormone and anti-growth factor resistance in breast cancer through signal transduction/pharmacological challenge studies. Our current Tenovus-funded main programme is exploring very early anti-hormone-induced signal transduction that limits initial response and promotes cell survival permitting evolution of resistance. Such drug-induced compensatory signalling also promotes further features of progression (e.g. invasion) under particular cellular contexts. A pervading goal in our studies is to reveal new therapeutic targets to subvert resistance/progression and improve response, as well as providing new markers of therapeutic response & prognosis. |
| Models |
In house panel of in vitro models derived from MCF-7 and T47D reflective of acquired resistance to various antihormones and erbB inhbitors. Our collaborations are also utilising these models in 2D/3D cell culture. |
| Methods |
Cell culture and signal transduction methodologies (including Western Blotting/PCR/reporter assays, pharmacological/antibody challenge) are core for candidate pathway studies as applied to our breast cancer models. My own areas of expertise lie in immunocytochemistry, notably using phosphospecific antibodies and their application to clinical material. I have also recently coordinated Affymetrix microarray studies as applied to our panel of cell lines that are revealing novel signalling elements induced during early drug treatment or elevated in established resistance. The relevance of these changes is subsequently being explored through functional studies, including employing SiRNA knockdown. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
GLUKHOVA
|
| First name |
MARINA |
| Institution |
UMR 144 CNRS-Institut Curie, Institut Curie, Centre de Recherche |
| Country |
|
| Phone |
+33 1 42 34 63 31 |
| E-mail |
Marina.Glukhova@curie.fr |
| Website |
http://www.curie.fr/equipe/327
|
| Group leader since (year) |
1995 |
| Research interests |
Cell-extracellular matrix interactions mediated by integrins in mammary development
Wnt/ß-catenin signaling pathway in mammary tumorigenesis
Stem/progenitor cells in the adult mouse mammary epithelium |
| Models |
Transgenic mice, mouse models of human breast tumors, primary culture of mammary cells, mouse mammary cell lines |
| Methods |
Isolation of mouse mammary epithelial cells, 2-D and 3-D cultures, transplantation into the cleared mammary fat pad, FACS, microarrays |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
GOMPEL
|
| First name |
ANNE |
| Institution |
INSERM UMRS 938 Saint Antoine, Paris
Paris Descartes University |
| Country |
FRANCE |
| Phone |
0033149284692/0033142348768 |
| E-mail |
anne.gompel@htd.aphp.fr |
| Website |
|
| Group leader since (year) |
|
| Research interests |
human normal breast cells
hormonedependency |
| Models |
primary cultures of normal human cells
xenografts of normal tissues in nude mice
biopsies |
| Methods |
QPCR, IHC, Western blots, si |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Thursday, June 10, 2010 |
|
|
| |
| Last name |
GONZALEZ SUAREZ
|
| First name |
EVA |
| Institution |
Catalan Institute of Oncology (ICO) Cancer Epigenetics and Biology Program (PEBC) |
| Country |
|
| Phone |
34 932607500 Ext 3166 |
| E-mail |
egsuarez@iconcologia.net |
| Website |
http://www.pebc.cat/grupodetalle.php?idg=15
|
| Group leader since (year) |
2007 |
| Research interests |
Breast cancer and bone metastasis. RANK signaling. Tumor initiating cells. Mechanisms of resistance to current treatments. Inflammation and cancer. |
| Models |
3D cultures, suspension cultures, primary cell cultures, orthotopic transplants of human and mouse tumors, transgenic and KO mouse models |
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
GRONER
|
| First name |
BERND |
| Institution |
Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Str. 42, D-60596 Frankfurt am Main, Germany |
| Country |
|
| Phone |
+49 69 63395180 |
| E-mail |
groner@em.uni-frankfurt.de |
| Website |
http://www.georg-speyer-haus.de
|
| Group leader since (year) |
1982 |
| Research interests |
mammary gland biology, breast cancer, experimental therapeutics, cytokine signaling |
| Models |
mammary gland reconstitution, genetically modified mammary stem cells, in vitro differentiation |
| Methods |
cleared fat pad transplantation, lentiviral mediated transgenesis |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
great initiative |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
HILKENS
|
| First name |
JOHN |
| Institution |
Netherlands Cancer Institute |
| Country |
|
| Phone |
+31 20 512 2018 |
| E-mail |
j.hilkens@nki.nl |
| Website |
http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Ge...
|
| Group leader since (year) |
1982 |
| Research interests |
The aim of my laboratory is to identify and study novel genes involved in breast cancer and unravel the collaborating genetic pathways leading to breast cancer and breast cancer progression using mouse mammary tumor virus (MMTV) induced insertional mutagenesis in mouse models. genes of interest: R-spondin genes, Irs genes and membrane associated mucins (MUC1) |
| Models |
various mouse models including K14-cre; p53f/f and MMTV cNeu transgenics |
| Methods |
High throughput in vivo MMTV mediated insertional mutagenesis screens, protein biochemistry, retroviral transduction, in vivo tumorigeneicity and metastasis assay's |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
HOPKINS
|
| First name |
ANN |
| Institution |
Royal College of Surgeons in Ireland |
| Country |
IRELAND |
| Phone |
+35318093858 |
| E-mail |
annhopkins@rcsi.ie |
| Website |
http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=253&pip=team#...
|
| Group leader since (year) |
2005 |
| Research interests |
- Altered cell-cell and cell-matrix adhesion in breast cancer progression;
- The role of junction adhesion molecule-A (JAM-A) in breast cancer invasion;
- Lipid rafts as modulators of cell migration;
- Breast progenitor cells |
| Models |
Primary cultures of human breast tumours
Tissue microarrays
3-dimensional cell culture models |
| Methods |
Protein biochemistry
Confocal microscopy
Functional assays relevant to cell motility |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, November 05, 2009 |
|
|
| |
| Last name |
HOWARD
|
| First name |
BEATRICE |
| Institution |
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London |
| Country |
|
| Phone |
+ 44 (0) 207 153 5177 |
| E-mail |
beatrice.howard@icr.ac.uk |
| Website |
http://www.breakthroughcentre.org.uk/research_groups/gene_function/bre...
|
| Group leader since (year) |
|
| Research interests |
mammary morphogenetic events with relevance to breast cancer etiology: Neuregulin3 (Nrg3) and Erbb4 signalling, embryonic mammary gland development, mammary lineage commitment and differentiation |
| Models |
knockout and transgenic mice, ex vivo culture |
| Methods |
general molecular, cellular and developmental biology techniques, qPCR, IF, ISH, protein analysis, microdissection, etc. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, August 25, 2008 |
|
|
| |
| Last name |
HYNES
|
| First name |
NANCY |
| Institution |
Friedrich Miescher Institute for Biomedical Research |
| Country |
|
| Phone |
41 61 697 8107 |
| E-mail |
hynes@fmi.ch |
| Website |
http://www.fmi.ch/hynes.n
|
| Group leader since (year) |
1981 |
| Research interests |
Breast cancer, ErbB family of receptor tyrosine kinases, mammary gland development, FGFRs, Wnt pathway, cell migration, |
| Models |
Transgenic mammary tumor models, 4T1 mammary cancer model, human tumor xenograft models. mouse premature aging model |
| Methods |
Protein analysis, migration, FACs, animal cancer models, etc |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
IGGO
|
| First name |
RICHARD |
| Institution |
Bergonie Cancer Institute, University of Bordeaux |
| Country |
|
| Phone |
00 33 5 56 33 04 23 |
| E-mail |
richard.iggo@me.com |
| Website |
http://www.bergonie.org/fr/basic-research/richard-iggo.html
|
| Group leader since (year) |
1991 |
| Research interests |
Prediction of response to chemotherapy using gene signatures. Role of p53 in breast cancer. Quantitative transformation of normal mammary epithelial cells. |
| Models |
Orthotopic xenografts in NOD/SCID mouse mammary glands. |
| Methods |
Lentiviral infection of HMECs and BPECs to express oncogenes and inactivate tumour suppressor genes. Affymetrix expression and SNP chips from clinical samples. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Tuesday, December 08, 2009 |
|
|
| |
| Last name |
JONKERS
|
| First name |
JOS |
| Institution |
Netherlands Cancer Institute |
| Country |
|
| Phone |
+31-20-5122000 |
| E-mail |
j.jonkers@nki.nl |
| Website |
http://research.nki.nl/molbio/Groups/jonkers/jonkersgroup.htm
|
| Group leader since (year) |
2003 |
| Research interests |
BRCA1- and BRCA2-associated breast cancer, E-cadherin-mutated lobular breast cancer, inflammation and cancer, cancer stem cells, targeted anticancer therapeutics |
| Models |
Conditional knockout and transgenic mice, in vitro cultures, orthotopic grafting models |
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
KAENEL
|
| First name |
PHILIP |
| Institution |
Department for Clinical Research University of Bern |
| Country |
SWITZERLAND |
| Phone |
|
| E-mail |
philip.kaenel@dkf.unibe.ch |
| Website |
|
| Group leader since (year) |
|
| Research interests |
Ephrin-B2 and EphB4 in mammary gland development |
| Models |
|
| Methods |
Flow cytometry, in vivo assays, in vitro colony-forming and mammopshere assays, confocal microscopy |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Friday, June 18, 2010 |
|
|
| |
| Last name |
KRESS
|
| First name |
CLEMENCE |
| Institution |
Institut National de la Recherche Agronomique (INRA) |
| Country |
|
| Phone |
+33 (0) 1 34 65 25 54 |
| E-mail |
Clemence.Kress@jouy.inra.fr |
| Website |
http://w3.jouy.inra.fr/unites/gpl/index.shtml
|
| Group leader since (year) |
|
| Research interests |
The unit works on genomics and physiology of lactation: hormonal signalisation, gene expression control, synthesis of milk components, membrane traffic, endo/exocytosis pathways. |
| Models |
Rabbit, cattle and mouse mammary gland tissue. |
| Methods |
Cryosections of mammary tissue for DNA, RNA FISH, IF. Preservation of nuclear structure, confocal microscopy, 3D reconstitution and modelling |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, August 25, 2008 |
|
|
| |
| Last name |
OREND
|
| First name |
GERTRAUD |
| Institution |
INSERM U682, De l`homéostasie tissulaire au cancer et à l`inflammation
Equipe: Impact du microenvironnement sur l`angiogenèse et l`invasion tumorale |
| Country |
FRANCE |
| Phone |
33 (0)3 88 27 53 55 |
| E-mail |
gertraud.orend@inserm.u-strasbg.fr |
| Website |
http://u682-inserm.u-strasbg.fr
|
| Group leader since (year) |
2002 |
| Research interests |
Extracellular matrix in tissue homeostasis, inflammation, angiogenesis, metastasis, stem cells, tenascin-C, laminins |
| Models |
3D cultures, ex vivo culture models (HMECs...), transgenic and KO tenascin-C and laminin-111 mice |
| Methods |
cell culture assays, BiAcore, biochemistry (western blot, IP, QPCR..), tissue analysis |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, November 19, 2009 |
|
|
| |
| Last name |
ORIAN-ROUSSEAU
|
| First name |
VÉRONIQUE |
| Institution |
Karlsruhe Institute of Technology, Institute for Toxicology and Genetics |
| Country |
|
| Phone |
+497247826523 |
| E-mail |
veronique.orian-rousseau@kit.edu |
| Website |
http://itgmv1.fzk.de/itg/orian-rousseau/orian-rousseau.html
|
| Group leader since (year) |
2003 |
| Research interests |
Molecular mechanisms involved in tumor progression, Receptor Tyrosine Kinases (EGFR, c-Met, VEGFR..) activation and internalisation, Cell Adhesion Molecules (in particular CD44, ICAM), Role of CD44 in Breast Cancer Stem cells, Signal Transduction |
| Models |
CD44 knock out, Xenograft, pancreas orthotopic models |
| Methods |
KO technology, Transgenic, Angiogenesis assays, |
List of transgenic and KO
mice available |
Yes
|
Comments
(including wish list) |
CD44 floxed mice |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Wednesday, December 02, 2009 |
|
|
| |
| Last name |
PAGES
|
| First name |
GILLES |
| Institution |
University of Nice Sophia Antipolis UMR CNRS 6543 |
| Country |
|
| Phone |
00 33 4 92 03 12 31 |
| E-mail |
gpages@unice.fr |
| Website |
|
| Group leader since (year) |
1999 |
| Research interests |
Normal and tumor angiogenesis. We are looking at the regulation of angiogenic factor VEGf and IL-8 in particular at the post transcriptional level. We are studying mRNA binding protein that destabilizes the mRNA. We are looking at the loss of mRNA degradative protein in breast cancer on tumor cell lines and on tumor samples. We are also looking at the effect of targetted therapy on the expression of these proteins |
| Models |
Cell with different metastatic potential with inducible expression of mRNA degradative protein, tumor samples |
| Methods |
Stable and transient transfection of genes of interest. In vivo imaging of tumor xenografts of cells with expression of luciferase. Determination of angiogenic factor by ELISA; Reporter genes (promoters and 3'UTR) |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
PELICCI
|
| First name |
PIER GIUSEPPE |
| Institution |
Experimental Oncology European Institute of Oncology and the Campus IFOM-IEO |
| Country |
|
| Phone |
0039-02-57489831 |
| E-mail |
piergiuseppe.pelicci@ifom-ieo-campus.it |
| Website |
http://www.ifom-ieo-campus.it/
|
| Group leader since (year) |
1987 |
| Research interests |
1.Hematopoietic stem cells and Acute Myeloid Leukemias 2. Breast stem cells and breast cancer 3.Effects of checkpoint activation on tissue homeostasis and molecular mechanisms of aging 4. Epigenetics and environmental cancer risk assessment |
| Models |
Mammospheres; KO and transgenic mice, humanized mouse, conditional and constitutive models |
| Methods |
Cell culture (primary cell culture; cell lines) and mouse models; 3D cultures; xenografts; standard molecular and cell biology techniques; time-lapse microscopy; FACS sorting; siRNA technology; DNA microarrays, tissue microarrays; ChIP, ChIP-chip and ChIP-Seq. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, December 17, 2009 |
|
|
| |
| Last name |
RIETHDORF
|
| First name |
SABINE |
| Institution |
Institute of Tumor Biology, University Medical center Hamburg-Eppendorf, Germany |
| Country |
|
| Phone |
0049-40-42803-2628 |
| E-mail |
s.riethdorf@uke.uni-hamburg.de |
| Website |
http://www.uke.uni-hamburg.de/institute/tumorbiologie
|
| Group leader since (year) |
>10 |
| Research interests |
Disseminated and circulating tumor cells in bone marrow and blood, molecular and phenotypical characterization of DTC, CTC, breast cancer, stem cells |
| Models |
|
| Methods |
Enrichment, detection and characterization of DTC, CTC, automatic detection systems, in situ hybridization (DNA; RNA) |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, August 25, 2008 |
|
|
| |
| Last name |
RIO
|
| First name |
MARIE-CHRISTINE |
| Institution |
Institut de Génétique et de Biologie Moléculaire et Cellulaire |
| Country |
|
| Phone |
0388653424 |
| E-mail |
rio@igbmc.u-strasbg.fr |
| Website |
|
| Group leader since (year) |
1989 |
| Research interests |
Molecular biology of breast cancers. Normal and pathological function of few genes: pS2/TFF1, ST3/MMP11, MLN64, MLN51 and TRAF4, all cloned in the laboratory.
Proteomic of breast cancers |
| Models |
Knock-out mice for the genes cited above.
Several models of tumorigenesis in mice |
| Methods |
Cellular and molecular biology
Transgenic mice |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
ROTTENBERG
|
| First name |
SVEN |
| Institution |
The Netherlands Cancer Institute |
| Country |
|
| Phone |
+31 20 5122082 |
| E-mail |
s.rottenberg@nki.nl |
| Website |
|
| Group leader since (year) |
|
| Research interests |
mouse models for anti-cancer drug resistance |
| Models |
K14-cre, Brca1F/F, p53F/F
Ref.:
Liu et al., PNAS 104, 12111-12116, 2007
Rottenberg et al., PNAS 104, 12117-22, 2007 |
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, August 25, 2008 |
|
|
| |
| Last name |
SCHMITT
|
| First name |
FERNANDO |
| Institution |
IPATIMUP, Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias, s/n4200-465 PortoPortugalRua Dr. Roberto Frias, s/n |
| Country |
|
| Phone |
+351-225570700 |
| E-mail |
fernando.schmitt@ipatimup.pt |
| Website |
http://www.ipatimup.pt
|
| Group leader since (year) |
1995 |
| Research interests |
Breast cancer pathology; basal-like carcinomas; basal cell markers; breast cancer stem cells; P-cadehrin role in breast carcinogenesis: regulation and function; HER-2/EGFR-targeted therapy resistance; vitamin D effect in controlling breast cancer; PTEN role in breast cancer |
| Models |
In vitro cell culture; breast cancer tissue series; tissue microarrays (TMAs); mice xenografts |
| Methods |
Microscopy; immunohisto/cytochemistry; cell culture; western-blot; immunoprecipitation; siRNA technology; real-time PCR; cell invasion and aggregation assays; time-lapse microscopy; proteomics; cDNA cloning; luciferase-reporter assays |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
None |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
SCHULER
|
| First name |
LINDA |
| Institution |
University of Wisconsin--Madison |
| Country |
UNITED STATES |
| Phone |
001-608-263-9825 |
| E-mail |
schulerl@svm.vetmed.wisc.edu |
| Website |
|
| Group leader since (year) |
long time |
| Research interests |
hormonal contributions (especially prolactin) to the development, progression and therapeutic responsiveness of breast cancer |
| Models |
human breast cancer cell lines, NRL-PRL transgenic mouse model |
| Methods |
in vitro and in vivo |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, July 12, 2010 |
|
|
| |
| Last name |
SIERRA
|
| First name |
ANGELS |
| Institution |
IDIBELL |
| Country |
|
| Phone |
34 93 2607429 |
| E-mail |
asierra@idibell.org |
| Website |
http://www.idibell.org/
|
| Group leader since (year) |
1997 |
| Research interests |
Apoptotis, Breast cancer, Diagnostic markers, Metastasis pathogenesis, New diagnostic tools |
| Models |
Metastatic variants from human breast carcinomas, Brain and lung metastasis models in nude mice, Primary cultures of metastatic cells |
| Methods |
Bioinformatics, Cell biology, IHC, Proteomics, Tissue array |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
SLEEMAN
|
| First name |
JONATHAN |
| Institution |
University of Heidelberg, Medical Faculty Mannheim, Ludolf-Krehl-Str 13-17, 68167 Mannheim, Germany and Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, 76021 Karlsruhe, Germany |
| Country |
|
| Phone |
+49 621 383 9955 |
| E-mail |
sleeman@medma.uni-heidelberg.de |
| Website |
http://www.ma.uni-heidelberg.de/inst/cbtm/mbio/
|
| Group leader since (year) |
1997 |
| Research interests |
Tumor metastasis, particularly the role of the lymphatic system in tumor dissemination, the role of cancer stem cells in metastasis and the microenvironment that supports metastatic growth |
| Models |
Knockout and transgenic mice, transplantable syngeneic and xenograft tumor models, in vitro cell models |
| Methods |
Animal technology, standard immunohistochemistry, molecular and cell biology techniques, primary cell culture, FACS sorting, microarray, in vitro metastasis assays, time lapse, cell encapsulation, synthetic organic chemistry, various immunoassays, yeast 2 hybrid, confocal, whole mounts, etc |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
SMALLEY
|
| First name |
MATT |
| Institution |
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research |
| Country |
|
| Phone |
+44 (0)207 153 5546 |
| E-mail |
matthew.smalley@icr.ac.uk |
| Website |
http://www.breakthroughcentre.org.uk/research_groups/mammary_stem_cell...
|
| Group leader since (year) |
2006 |
| Research interests |
Stem cells in normal and neoplastic mammary epithelium; control of self-renewal and differentiation in mammary stem cells |
| Models |
In vivo mouse mammary gland |
| Methods |
Harvest of primary mouse mammary epithelium; multicolour flow cytomtery; cleared fat pad transplantation; qPCR |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
SMITH
|
| First name |
GILBERT |
| Institution |
National Cancer Institute |
| Country |
UNITED STATES |
| Phone |
1-0-301-496-2385 |
| E-mail |
gs4d@nih.gov |
| Website |
|
| Group leader since (year) |
|
| Research interests |
Mammary gland development, stem cell hierarchy in epithelium, growth senescence, cancer, mutations relevant to mammary epithelial transformation |
| Models |
CzechII mice (no MMTV provirus in genome); WAPCre/Rosa26flox-STOP-flox-lacZ model, reprogramming non-mammary cells in mouse mammary glands during outgrowth |
| Methods |
Tissue culture
Transplantation
Microscopy |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
Not in Europe but happy to connect and collaborate/consult with members of this group... |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, June 21, 2010 |
|
|
| |
| Last name |
SONNENBERG
|
| First name |
ARNOUD |
| Institution |
The Netherlands Cancer Inst. |
| Country |
|
| Phone |
31-20-5121942 |
| E-mail |
a.sonnenberg@nki.nl |
| Website |
|
| Group leader since (year) |
1990 |
| Research interests |
Role of laminin-binding integrins and associated proteins in mammary gland development, mammary differentiation and tumorigenesis. Hemidesmosomes, integrin signaling, diagnostic markers for mammary gland development and stem cells in normal and neoplastic epithelium |
| Models |
Conditional knockout mice for the integrin alpha3 (Iga3), beta4 (Itgb4) and the tetraspanin CD151. |
| Methods |
Microscopy, immunohistochemistry, cell culture, protein biochemistry, KO and transgenic mice, etc. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
None |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
STEIN
|
| First name |
TORSTEN |
| Institution |
Division of Cancer Sciences and Molecular Pathology, University of Glasgow |
| Country |
|
| Phone |
+44 (0)141 211 1942 |
| E-mail |
T.Stein@clinmed.gla.ac.uk |
| Website |
http://www.gla.ac.uk/departments/cancersciences/pathologyandgeneregula...
|
| Group leader since (year) |
2006 |
| Research interests |
mammary gland development; involution; terminal end buds; breast cancer development. We are trying to identify and characterise novel pathways that are involved or control key stages of mammary gland development, and that may be deregulated in breast cancer. Particular genes of interest: Annexin A8, Reelin, TSC-22. |
| Models |
normal mouse; TSC-22D1i2 transgenic mice |
| Methods |
microarrays, IF, IHC, standard cell and molecular biology |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
none |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Tuesday, December 01, 2009 |
|
|
| |
| Last name |
STINGL
|
| First name |
JOHN |
| Institution |
Cancer Research UK Cambridge Research Institute |
| Country |
UNITED KINGDOM |
| Phone |
44 1223 404 353 |
| E-mail |
john.stingl@cancer.org.uk |
| Website |
http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/stinglj/...
|
| Group leader since (year) |
2008 |
| Research interests |
Mouse and human mammary gland stem cells. Basal-like breast cancer. Mechanisms of resistance to anti-estrogen therapies |
| Models |
|
| Methods |
In vivo mammary stem cell assays. In vitro colony forming assays. Flow cytometry |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Tuesday, March 03, 2009 |
|
|
| |
| Last name |
STREULI
|
| First name |
CHARLES |
| Institution |
University of Manchester |
| Country |
|
| Phone |
+44 161 27 5626 |
| E-mail |
cstreuli@manchester.ac.uk |
| Website |
http://www.breastcentre.manchester.ac.uk/
|
| Group leader since (year) |
1991 |
| Research interests |
normal mammary gland development and function; integrins and integrin signalling; extracellular matrix; apoptosis; inhibitor-of-apoptosis-proteins; early breast cancer |
| Models |
primary mammary cell cultures; mammary-specific gene deletion in vivo and culture |
| Methods |
primary cell culture; 3D culture; 3D immunstaining; gene deletion in vivo with mammary-specific Cre; gene deletion in primary culture with 4-OHT (CreER) or viral infection with adenoCre; apoptosis methods; siRNA oligos, shRNA vectors and shRNA lentiviruses |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
VAN DE WATER
|
| First name |
BOB |
| Institution |
Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands |
| Country |
|
| Phone |
31 71-5276223 |
| E-mail |
b.water@lacdr.leidenuniv.nl |
| Website |
|
| Group leader since (year) |
1999 |
| Research interests |
Role of cell-ECM signaling in mammary gland development and breast cancer development and progression/metastasis. Integrated signaling between receptor protein tyrosine kinase and focal adhesion kinase (FAK). FAK-mediated signaling. |
| Models |
Conditional knockouts for FAK and p53. Mammary gland reconstitution models. Orthotopic breast tumor/metastasis models. 2D and 3D migration/invasion models. 3D branching morphogenesis models. Models for focal adhesion dynamics. |
| Methods |
siRNA and shRNA libraries. Retro- and lenti-viral transduction of MMEC and breast tumor cell lines. 2D and 3D MEC cultures. Live cell imaging (spectral imaging, TIRF microscopy, confocal, DIC) followed by quantitative image analysis. Fluorescence and bioluminescence analysis of breast cancer progression. Conditional expression of DN and DA target genes in orthotopic breast tumor models. Intravital imaging of breast tumor cell migration in primary tumor. Gene expression profilling. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
VAN LOHUIZEN
|
| First name |
MAARTEN |
| Institution |
The Netherlands Cancer Institute |
| Country |
|
| Phone |
+31-20-5122030 |
| E-mail |
m.v.lohuizen@nki.nl |
| Website |
http://research.nki.nl/lohuizenlab/
|
| Group leader since (year) |
1995 |
| Research interests |
We study epigenetic gene regulation and transcriptional repression by Polycomb-group (Pc-G) protein complexes, and the effects of deregulation of Pc-G genes on development, Cell cycle control, cancer formation and stem cell maintenance. In addition, we are performing large-scale genetic screens in primary cells and in cancer-predisposed mice to identify cancer-relevant combinations of collaborating oncogenes and tumor-suppressor genes. |
| Models |
Diverse animal models: Bmi1 KO and conditional KO mice; EZH2 conditional KO mice, RNF2 conditional KO mice;Tissue-specific inducible Bmi1 transgenic mice;MMTV-Wnt1; MMTV-NEU; MMTV-Myc; |
| Methods |
mouse and human ES cell technologies, fat pad transplantation, 2D MEC culture, protein biochemistry, high content screening, lentiviral or retroviral transduction, stem cell FACS sorting, DAMid chromatin profiling, High throughput in vivo retroviral insertional mutagenesis screens |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
VAN RHEENEN
|
| First name |
JACCO |
| Institution |
Hubrecht Institute |
| Country |
NETHERLANDS |
| Phone |
+31 (0)30-2121905 |
| E-mail |
j.vanrheenen@hubrecht.eu |
| Website |
http://www.niob.knaw.nl/research/vanrheenen/index.html
|
| Group leader since (year) |
2008 |
| Research interests |
Complication of metastasis, the process in which cells detach from the primary tumor to form new distant tumor sites, is the primary reason why women die from breast cancer. The metastatic behavior of tumor cells is highly dependent on the cell’s intrinsic characteristics and on the tumor microenvironment, such as stromal cells and the extracellular matrix. We study both by combining conditional mouse models that recapitulate human breast tumors and intravital imaging techniques (high resolution imaging of metastasis in living animals in real time). By these experiments we hope to indentify new drug targets that combined with current clinical approaches may lead to new therapies. |
| Models |
allograft tumor models:1) Ola/FVB mice with Kep1_11 cells (Cdh-/-;Trp53-/-, Derksen et al, Canc Cell 2004)2) BalbC with 4T1 cell line. Genetic model:MMTV-Neu tumor model |
| Methods |
Our lab studies the behavior of metastasizing tumor cells inside living mice by intravital imaging; the imaging of living tissue. Whole mice bearing metastasizing tumors are imaged at subcellular resolution by confocal or two-photon microscopy. Our lab, together with the labs of Drs Segall and Condeelis (Albert Einstein College of Medicine, Bronx, NY, USA) has developed a mammary gland imaging window in order to image and track cells for multiple days inside mammary tumors in living mice. Moreover, we use intravital FRET imaging to study activity of several signaling pathways inside metastasizing tumor cells. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, January 11, 2010 |
|
|
| |
| Last name |
VANHAESEBROECK
|
| First name |
BART |
| Institution |
Centre for Cell Signalling - Institute of Cancer - Barts and the London Medical School - |
| Country |
|
| Phone |
00-44-207-882-8201 |
| E-mail |
bart.vanh@qmul.ac.uk |
| Website |
http://www.cancer.qmul.ac.uk/research/cell_signalling/
|
| Group leader since (year) |
1998 |
| Research interests |
Signal transduction - cancer and inflammation |
| Models |
mouse models - knock-in gene-targeting - PI 3-kinase and related pathways |
| Methods |
standard cell and molecular biology - biochemistry - mass spectrometry |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
special interest in cancer and inflammation, in relation to breast cancer |
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
VELTMAAT
|
| First name |
JACQUELINE |
| Institution |
A*STAR Institute of Molecular and Cell Biology |
| Country |
SINGAPORE |
| Phone |
+65 6586 9618 |
| E-mail |
jmveltmaat@imcb.a-star.edu.sg |
| Website |
http://www.imcb.a-star.edu.sg/php/jv.php
|
| Group leader since (year) |
2006 |
| Research interests |
- molecular regulation of embryonic phase of mammary gland development (in particular induction) as well as postnatal morphogenesis and differentiation
- creation of software for image analysis |
| Models |
mouse mutants |
| Methods |
histology, RNA-RNA in situ hybridization and immunochemistry on whole mount and sectioned embryos, tissue separation and recombination, organ culture, transplantation, micro-array |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, July 08, 2010 |
|
|
| |
| Last name |
VENEZIANI
|
| First name |
BIANCA MARIA |
| Institution |
Dipartimento di Biologia e Patologia Cellulare e Molecolare Facoltà di Medicina e Chirurgia Università di Napoli "Federico II" |
| Country |
ITALY |
| Phone |
390817463758 |
| E-mail |
bianca.veneziani@unina.it |
| Website |
http://www.dbpcm.org/cms/
|
| Group leader since (year) |
2000 |
| Research interests |
Human breast cancer, steroid receptors, signalling and stem cells. Mechanisms of resistance to current treatments. Stromal and adipose tissue of the mammary gland. |
| Models |
Breast cancer epithelial-stromal co-cultures, mammospheres. |
| Methods |
Primary cell culture, breast cancer cell lines, in vitro analysis of the tumor-stroma interaction, cryopreservation, qPCR, FACS, stem cell sorting, RNA and protein analyses. |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Friday, January 29, 2010 |
|
|
| |
| Last name |
VIVANCO
|
| First name |
MARIA |
| Institution |
CIC bioGUNE, Cell Biology and Stem Cells Unit,
Bilbao, Spain |
| Country |
|
| Phone |
+34 94 406 1322 |
| E-mail |
mdmvivanco@cicbiogune.es |
| Website |
http://www.cicbiogune.es/
|
| Group leader since (year) |
1997 |
| Research interests |
Steroid hormone receptors, human mammary gland, breast cancer, stem cells, regulation of self-renewal and differentiation in human breast stem cells |
| Models |
human mammary epithelial cells |
| Methods |
2D and 3D cultures, FACS, qPCR, multiplex RT-PCR, general molecular and cellular biology |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
WATSON
|
| First name |
CHRISTINE |
| Institution |
University of cambridge |
| Country |
|
| Phone |
+44 1223 333725 |
| E-mail |
cjw53@cam.ac.uk |
| Website |
http://www.path.cam.ac.uk~madgroup
|
| Group leader since (year) |
|
| Research interests |
|
| Models |
|
| Methods |
|
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, June 07, 2010 |
|
|
| |
| Last name |
WHITELAW
|
| First name |
BRUCE |
| Institution |
Roslin Institute and Royal (Dick) School of Veterinary Studies
Univeristy fo Edinburgh
Roslin
Midlothian EH25 9PS, UK |
| Country |
|
| Phone |
+44-(0)131-527-4200 |
| E-mail |
bruce.whitelaw@rolsin.ed.ac.uk |
| Website |
|
| Group leader since (year) |
1994 |
| Research interests |
gene transfer
gene expression systems
cancer
stem cell biology
mammary growth and development |
| Models |
transgenic mice
transgenic sheep and pigs |
| Methods |
general molecular biology |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Monday, September 29, 2008 |
|
|
| |
| Last name |
WIESMÜLLER
|
| First name |
LISA |
| Institution |
Gynaecological Oncology, Head
Department of Obstetrics and Gynaecology of the University of Ulm |
| Country |
GERMANY |
| Phone |
+49-(0)731-500-58800/58801 |
| E-mail |
lisa.wiesmueller@uni-ulm.de |
| Website |
http://www.uni-ulm.de/klinik/ufk/cms/html/forschung_gyn-onko.htm
|
| Group leader since (year) |
2001 |
| Research interests |
apoptosis
breast cancer risk
chemoprevention
DNA double strand break repair
homologous recombination
replication fork stalling
prediction of therapeutic responsiveness |
| Models |
- patient cell lines
- peripheral lymphocytes, fibroblasts, and primary epithelial cells from mammary gland of probands/patients
- MEFs from mice differing in breast cancer susceptibilities |
| Methods |
- analysis of distinct DNA double strand repair pathways
- nuclear foci analysis for DNA damage/repair factors
- apoptosis analyses
- characterization of genotoxic, chemopreventive, and therapeutic agents agents |
List of transgenic and KO
mice available |
No
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
No
|
Last update
|
Monday, September 07, 2009 |
|
|
| |
| Last name |
YOUNG
|
| First name |
LEONIE |
| Institution |
Royal College of Surgeons in Ireland |
| Country |
IRELAND |
| Phone |
+35314028576 |
| E-mail |
lyoung@rcsi.ie |
| Website |
http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=35&pip=pubs#t...
|
| Group leader since (year) |
2001 |
| Research interests |
- Coactivator proteins in endocrine-resistant breast cancer
- Identification of biomarkers to predict endocrine-sensitivity and endocrine-resistance in breast cancer patients |
| Models |
Breast cancer patient primary cultures
Tissue microarrays
Murine tumour models |
| Methods |
Immunohistochemistry
In situ FRET
CHIP-Seq
Transcription factor binding |
List of transgenic and KO
mice available |
Yes
|
Comments
(including wish list) |
|
Mailing list
(managed by webmaster) |
Yes
|
Last update
|
Thursday, November 05, 2009 |
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