European Network of Breast Development and Cancer labs

EUROPEAN NETWORK OF BREAST DEVELOPMENT AND CANCER LABS

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LIST OF EUROPEAN LABS WORKING IN THIS RESEARCH AREA:

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Last name	BENTIRES-ALJ
First name	MOHAMED (MOMO)
Institution	Friedrich Miescher Institute for Biomedical Research (FMI)
Country	SWITZERLAND
Phone	+ 41 (0) 61 69 74048
E-mail	Bentires@fmi.ch
Website	http://www.fmi.ch/bentires-alj.m
Group leader since (year)	2006
Research interests	Breast development and cancer, protein tyrosine phosphatases, epithelial-stroma interactions, stem cells, 11q13 amplification, signaling
Models	3D cultures, ex vivo culture models (HMECs...), xenograft, KO and transgenic mice, humanized mouse
Methods
List of transgenic and KO mice available	No
Comments (including wish list)	none
Last update	Wednesday, January 05, 2011

Last name	BIRNBAUM
First name	DANIEL
Institution	Centre de Recherche en Cancérologie de Marseille, UMR599 Inserm and Institut Paoli-Calmettes
Country
Phone	33 4 91 75 84 07
E-mail	birnbaum@marseille.inserm.fr
Website	http://crcm-en.marseille.inserm.fr/
Group leader since (year)	1987
Research interests	Molecular Oncology, Oncogenomics, Breast cancer, Leukemia, Colon cancer, Tyrosine kinases, Oncogenes, Prognosis markers, Mitosis, Centrosome.
Models	Human pathologies, cell lines, mouse models.
Methods	DNA microarrays, array-CGH, FISH, sequencing, tissue microarrays, videomicroscopy, confocal microscopy, transgenesis, xenografts.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	BONIZZI
First name	GIUSEPPINA (GIUSY)
Institution	European oncology institute (IEO)
Country
Phone	+390257489396
E-mail	giuseppina.bonizzi@ifom-ieo-campus.it
Website
Group leader since (year)
Research interests	Breast Stem cell and Breast cancer stem cell
Models	3D cultures, xenograft, KO and transgenic mice, humanized mouse
Methods
List of transgenic and KO mice available	No
Comments (including wish list)	none
Last update	Monday, August 25, 2008

Last name	BØRRESEN-DALE
First name	ANNE-LISE
Institution	Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
Country
Phone	+47 22 78 13 73
E-mail	a.l.borresen-dale@medisin.uio.no
Website	http://www.radium.no/genetics/
Group leader since (year)	>20 years
Research interests	The Department's Research vision is exploring The Systems Biology of Breast Cancer Our research program is focusing on the molecular biology of breast and ovarian cancer with emphasis on identification of genotypes and gene expression profiles contributing to elevated cancer risk, radiation sensitivity, tumor aggressiveness and therapy resistance. The hypothesis is that both the geno- and phenotype of the tumor as well as the patients own genotype (the genetic “makeup” of the patient constituted by both high and low penetrance genes) play a role in breast and ovarian cancer risk, in the type of cancer developed, the disease course and the response to treatment. The results may be used to identify high-risk individuals that may benefit from preventing strategies, and to individualize the treatment of patients with respect to choice of drugs as well as to dose and duration. This may give a better therapeutic effect and less adverse reactions in the individual patient. Goals: 1. To join forces and expertise to create a world-leading Breast Cancer Research Center including The Dept of Medical Statistic Faculty of Medicine, Dept of Informatics, Faculty of Mathematics and Natural Sciences, UiO, The Norwegian Radium Hospital, Ullevål Univ. Hospital and potentially other hospitals in the Oslo area 2. To follow the linear time course of predisposition, initiation, early stages and advanced disease and to dissect the molecular mechanisms triggered at each stage 3. To follow the multidimentional interactions at various levels in a systems biology approach
Models	large cohorts of breast cancer patients with long term follow up, and healty woman participating in a population based study NOWAC http://uit.no/kk/NOWAC/
Methods	large scale analyses using various array technology to perform WGA on SNPs and CNVc, blood expression (mRNA and miRNA), Tumor mRNA and miRNA expression, aCGH, mutation, methylation and protein anaalyses using RPPA
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Tuesday, July 20, 2010

Last name	BRACKE
First name	MARC
Institution	Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Country
Phone	+32 9 332 3007
E-mail	brackemarc@hotmail.com
Website	http://www.ugent.be/people?ugentid=801000436153
Group leader since (year)	2003
Research interests	Mechanisms of tumor invasion and metastasis, mammary cancer, stromal interactions with cancer cells (myofibroblasts, adipocytes and stem cells), cytoskeleton and motility, cadherin/catenin complexes in cell-cell adhesion, endoplasmic reticulum stress, radiation-induced effects on invasion, new circulating tumor markers, invasion suppressor genes, early metastasis genes, hormones and breast cancer.
Models	3D-models for invasion in vitro (embryonic chick heart, type I collagen, Matrigel, reconstituted tissues), metastasis models in laboratory mice, aggregation models for cell-cell adhesion, interaction models between stromal and cancer cells, directional migration models (wound healing, checker board analysis, radial aggregate outgrowth).
Methods	Organotypic confronting cultures for invasion, Western blot, immunoprecipitation, transfection, siRNA, time-lapse microscopy, immunohisto/cytochemistry, raising monoclonal antibodies, ELISA, assays for ER stress and apoptosis, cell irradiation, PCR…
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	BRACKENBURY
First name	WILLIAM
Institution	University of York
Country	UNITED KINGDOM
Phone	+44 (0)1904 328284
E-mail	william.brackenbury@york.ac.uk
Website	http://www.york.ac.uk/biology/research/molecular-cellular-medicine/wil...
Group leader since (year)	2011
Research interests	Breast cancer, voltage-gated sodium channels, cell migration, adhesion, metastasis
Models	Cell lines, xenografts, tumour samples
Methods	Adhesion and migration assays, confocal microscopy, protein biochemistry, electrophysiology, pharmacology, realtime PCR, in vivo imaging.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Friday, December 02, 2011

Last name	BRAGA
First name	VANIA
Institution	Molecular Medicine, NHLI, Faculty of Medicine Imperial College London
Country
Phone	+44 20 7594-3233
E-mail	v.braga@imperial.ac.uk
Website
Group leader since (year)	1996
Research interests	epithelial polarization and differentiation, signalling from cell-cell adhesion receptors, small GTPases, cell-cell adhesion, cadherin receptors, morphological transformation, cancer cell biology
Models	primary cultures of keratinocytes, cell lines
Methods	microinjection, microscopy, RNAi, RNAi screen, protein-protein interaction, cell-cell adhesion assays, yeast two-hybrid, Q-PCR. intracellular trafficking assays
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	BRISKEN
First name	CATHRIN
Institution	Swiss Institute for Experimental Cancer Research (ISREC) School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL)
Country	SWITZERLAND
Phone	41-21-6925851
E-mail	cathrin.brisken@epfl.ch
Website	http://www.nccr-oncology.ch/scripts/index.aspx?idd=85
Group leader since (year)	2001
Research interests	Mammary gland development, breast cancer, hormone action, intercellular communication, morphogenesis
Models	mouse mutant strains, primary human breast epithelial cells
Methods	tissue recombinations techniques, primary cultures of mouse and human breast epithelial cells, retro and lentiviral infections
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Sunday, January 11, 2009

Last name	BUESS
First name	MARTIN
Institution	Department of Research
Country
Phone	0041 61 265 50 74
E-mail	mbuess@uhbs.ch
Website
Group leader since (year)	2005
Research interests	Understanding the pathophysiology of breast cancer gene expression profiles by in vitro analysis of the tumor-stroma interaction
Models
Methods	primary cell culture, breast cancer cell lines, qPCR, HEEBO microarrays, FACS, standard molecular and cell biology techniques
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	BUSTELO
First name	XOSE
Institution	Salamanca Cancer Research Center / Centro de Investigacion del Cancer de Salamanca
Country	SPAIN
Phone	+34 923 29 4802
E-mail	xbustelo@usal.es
Website	http://www.cicancer.org/vergrupo.php?IdGrupo=3
Group leader since (year)	2006
Research interests	Our research is focused on the functional characterization of signal transduction molecules with oncogenic potential and, particularly, on the functional analysis of oncoproteins specialized in connecting the stimulation of membrane receptors with signaling routes that lead to both cytoskeletal change and mitogenic processes. Within this general objetive, the current research of our laboratory is aimed at solving the following biological issues: (1) Functional characterization of the Vav oncoprotein family, a group of signal transduction molecules that work as phosphorylation-dependent GDP/GTP exchange factors for the GTPases of the Rho/Rac family. (2) Functional analysis of specific members of Rho/Rac family of GTPases. (3)Characterization of intracellular positive and negative regulators of Rho/Rac GTPases. (4) Study of the cross-talk between cytoskeletal routes and other biological processes. (5) Characterization of the role of these signaling routes in cancer, paying attention to both intrinsic (proliferation, survival, metastasis) and extrinsic (angiogenesis, inflammatory response) pathways that affect the final fitness of tumors in vivo. (6) Characterization of the role of these signal transduction pathways in other high incidence health problems such as cardiovascular disease and the metabolic syndrome. (7) Development of new therapeutic avenues to treat those diseases using molecular targets belonging to those signaling routes. To achieve these aims, our laboratory utilizes a quite diverse collection of experimental tools, including biochemical analysis (i.e., determination of enzyme activities, post-translational modifications, protein-protein interactions), structural biology (i.e., determination of the three-dimensional structure of proteins), cell biology, cell signaling (i.e., characterization of the signaling routes used by the oncoproteins under study) transgenic and knockout mice, genetic models available in invertebrate species (Drosophila, yeast) as well as genomics, proteomics, and cellomics techniques.
Models	Human pathologies, cell lines, mouse models.
Methods	Signal transduction, cytoskeleton, DNA microarrays, proteomics, videomicroscopy, confocal microscopy, cell lines, primary epithelial cells, epithelial tumor biology, cardiovascular techniques, xenograft, KO and transgenic mice
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, December 01, 2011

Last name	CALDAS
First name	CARLOS
Institution	Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge
Country
Phone	+44(0)1223 404420
E-mail	cc234@cam.ac.uk
Website	http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/caldasc/...
Group leader since (year)	1997
Research interests	Breast cancer Genomics Cancer stem cells microRNA Oncogenes and tumor supressor genes 8p12
Models	Cell lines Human breast cancers Mouse models
Methods	Expression microarrays Array-CGH Bioinformatics Tissue microarrays Xenografts Mammosphere assay
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	CHARIOT
First name	ALAIN
Institution	Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry Unit, University of Liege, Belgium
Country
Phone	32 4 366 24 72
E-mail	alain.chariot@ulg.ac.be
Website	http://www.chimmed.ulg.ac.be
Group leader since (year)	2005
Research interests	Insight into the NF-kB and IRF-activating signaling pathways: Elucidation of the TBK1/IKKe-dependent cascades in vivo. Insight into their deregulations in breast cancer.
Models	We are currently generating a transgenic model for IKKe
Methods	Yeast-two hybrid, micro-array analyses, ChIP assays, kinase assays, IPs, Real-time PCRs.
List of transgenic and KO mice available	No
Comments (including wish list)	We are interested in exploring the oncogenic potential of two kinases, TBK1 and IKKe, by extending our knowledge from the molecular level to an in vivo model.
Last update	Monday, September 29, 2008

Last name	CINTI
First name	SAVERIO
Institution	Section of Anatomy, Dept. of Molecular Patholgy and Innovative Therapies, School of Medicine, University of Ancona (Politecnica delle Marche), Ancona, Italy
Country
Phone	+39 0712206088
E-mail	cinti@univpm.it
Website	http://www.univpm.it/Entra/Engine/RAServePG.php/P/320710012049/idsel/3...
Group leader since (year)	>20
Research interests	Adipose organ. Adipose tissue of the mammary gland. Interaction between epithelial cells in mammary gland and adipocytes. White adipose tissue. Brown adipose tissue. Transdifferentiation.
Models
Methods	Light microscopy. Immunohistochemistry. Immunocytochemistry. Confocal microscopy. Electron microscopy. LacZ and GFP mice. Morphometry. Micro-dissection. Whole mount tissue embedding, adipose cell culture
List of transgenic and KO mice available	No
Comments (including wish list)	Our data support the reversible transdifferentiation of milk secretory epithelial cells into adipocytes in the mammary gland. PNAS, 101, 48, 16801-16806, 2004; In vivo physiological transdifferentiation of adult adipose cells, De Matteis R, Zingaretti MC, Murano I, Vitali A, Frontini A, Giannulis I, Barbatelli G, Marcucci F, Bordicchia M, Sarzani R, Raviola E, Cinti S, Stem Cells. 2009 Nov;27(11):2761-8.
Last update	Thursday, May 06, 2010

Last name	CLARKE
First name	ROB
Institution	University of Manchester
Country
Phone	44-(0)161-446 3210
E-mail	robert.clarke@manchester.ac.uk
Website	http://www.breastcentre.manchester.ac.uk/
Group leader since (year)	2003
Research interests	Human breast cancer, normal breast tissue, steroid receptors, signalling and stem cells
Models	Primary human breast tissue xenografts and 3D breast cell culture: matrigel and mammospheres
Methods	FACS and MACS for stem cell enrichment. RNA and protein analyses.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	CLARKSON
First name	RICHARD
Institution	University of Cardiff School of Biosciences
Country
Phone	+2920 870249
E-mail	clarksonr@cf.ac.uk
Website	http://www.cardiff.ac.uk/biosi/research/genetics/index.html
Group leader since (year)	2005
Research interests	involution, apoptosis, programmed cell death, transcription factors, signaling, development, cancer
Models	mouse and human, normal and cancer cell lines mouse primary cell culture conditional KO and conditional transgenics mouse transgenic models of BC
Methods	chIP, microarrays, MRI, transgenesis, QPCR, immunodetection
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	COOMBES
First name	R CHARLES
Institution	Imperial College
Country
Phone	020 8383 5828
E-mail	c.coombes@imperial.ac.uk
Website	http://www.imperial.ac.uk/medicine/sora
Group leader since (year)	20+
Research interests	I run a laboratory of approximately 200 staff in which we are engaged in the development of new forms of treatment for breast cancer, particularly endocrine therapy. Over the past 20 years, my group has completed the clinical development of two steroidal aromatase inhibitors, including 4-hydroxyandrostenedione and exemestane and my laboratory is currently engaged in studies aimed at understanding the role of estrogen receptor a and estrogen receptor ß in human breast cancer. We are engaged in developing novel methods for prediction of response to endocrine therapy and also doing research aimed at understanding the mechanisms of resistance to endocrine therapy.
Models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	DAIDONE
First name	MARIA GRAZIA
Institution	Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (MI)
Country	ITALY
Phone	+39-02-2390-2238
E-mail	MariaGrazia.Daidone@istitutotumori.mi.it
Website	http://www.istitutotumori.mi.it/
Group leader since (year)	1997
Research interests	Identification and characterization of human breast cancer-initiating cells (BCICs) using different approaches.In vitro models to investigate novel therapies targeting BCICs. Gene expression profiling to identify prognostic and treatment-predictive signatures in breast tumors. Isolation and molecular characterization of circulating tumor cells. microRNA profiling of breast tumors stroma and plasma: associated with tumor progression.
Models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Saturday, March 26, 2011

Last name	DALE
First name	TREVOR
Institution	Cardiff University
Country
Phone	+44 29 2087 4652
E-mail	daletc@cardiff.ac.uk
Website	http://www.cardiff.ac.uk/biosi/contactsandpeople/stafflist/a-d/dale-tr...
Group leader since (year)	1992
Research interests	Wnt signalling, stem cells, drug discovery, biochemistry of Wnt signalling protein complexes, signalling pathway networks.
Models	gene targetted mice (knock-out and transgenic) for components of the Wnt pathway. GFP and luciferase reporter readouts for Wnt pathway activity.
Methods	ES cell technologies, fat pad transplantation, protein biochemistry, high content screening
List of transgenic and KO mice available	Yes
Comments (including wish list)	We have tetracycline-inducible mouse models that allow induction of Wnt pathway activators and repressors in the mammary gland.
Last update	Wednesday, December 01, 2010

Last name	DERKSEN
First name	PATRICK
Institution	University Medical Center Utrecht / Medical Oncology / Lab. of Experimental Oncology
Country
Phone	+31 88 75 68068
E-mail	p.w.b.derksen@umcutrecht.nl
Website	http://www.umcutrecht.nl/subsite/oncology/Research-groups/Derksen
Group leader since (year)	2007
Research interests	Mouse Models; Mammary gland development and cancer; Metastasis
Models	Human ILC and IDC cell lines; Conditional Mouse Models of ILC
Methods	Orthotopic transplantations; lentiviral transductions; In vivo imaging
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Tuesday, December 01, 2009

Last name	DEVILEE
First name	PETER
Institution	Leiden University Medical Center
Country
Phone	+31 71 526 9510
E-mail	p.devilee@lumc.nl
Website	http://www.lumc.nl
Group leader since (year)	1992
Research interests	Breast cancer susceptibility, somatic genetics, aneuploidy, loss of heterozygosity, genetical genomics
Models	Brca1 conditional KO, human breast cancer families, breast cancer populations
Methods	SNP genotyping, large scale sequencing, gene expression analysis
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	DI FIORE
First name	PIER PAOLO
Institution	FIRC Institute of Molecular Oncology (IFOM) Foundation, Via Adamello 16, Milano, Italy
Country
Phone	+39 02 574303257
E-mail	pierpaolo.difiore@ifom-ieo-campus.it
Website	http://www.ifom-ieo-campus.it/
Group leader since (year)	1987
Research interests	1. Transformation by growth factor and growth factor receptor molecules as a tool to study the normal pathways regulating cell growth and their alteration in the neoplastic process. 2. Mechanisms of mitogenic signal transduction and attenuation by growth factor receptors under normal and neoplastic conditions. 3. Breast stem cell biology
Models
Methods	DNA microarrays, tissue microarrays, primary cell culture, 3D breast cell culture, protein biochemistry,
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	DONTU
First name	GABRIELA
Institution	King's College iLondon
Country	UNITED KINGDOM
Phone	44(0)2071883027
E-mail	gabriela.dontu@kcl.ac.uk
Website
Group leader since (year)	2009
Research interests	mammary stem cells normal breast development breast cancer stem cells
Models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, May 13, 2009

Last name	EDWARDS
First name	PAUL
Institution	Department of Pathology and Hutchison-MRC Research Institute, University of Cambridge
Country
Phone	+44 1223 763338
E-mail	pawe1@cam.ac.uk
Website	http://www.path.cam.ac.uk/pages/edwards/
Group leader since (year)	1977
Research interests	Genomics of breast cancer, particularly chromosome translocations. Currently (2007) engaged in comprehensive analysis of translocation breakpoints in breast cancer cell lines, collecting fusion genes. Previous interest was development of normal and neoplastic mammary gland, particularly using genetic manipulation of gland by transplantation.
Models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, December 21, 2009

Last name	FERBY
First name	INGVAR
Institution	University College London (UCL)
Country
Phone	+44 (0)20 7679 6293
E-mail	i.ferby@ucl.ac.uk
Website	http://www.ucl.ac.uk/wibr/research/cancer/if
Group leader since (year)	2006
Research interests	Spatiotemporal control of ErbB receptor signalling in mammary gland development and carcinogenesis
Models	Knockout and transgenic mouse models.
Methods	General molecular cell biology, protein biochemistry and primary cell culture.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	FLINT
First name	DAVID
Institution	Strathclyde University
Country
Phone	+44 141 548 2693
E-mail	david.flint@strath.ac.uk
Website	http://www.strath.ac.uk
Group leader since (year)	20+
Research interests	insulin-like growth factors, EMT
Models	3D co-culture approaches
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, August 25, 2008

Last name	GALLAGHER
First name	WILLIAM
Institution	UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Country
Phone	+353-1-7166743
E-mail	william.gallagher@ucd.ie
Website	http://www.ucd.ie/conway/cv_188.html
Group leader since (year)	1999
Research interests	(1) Systematic approaches to cancer biology, (2) Molecular basis of tumour progression, particularly metastasis, (3) Cancer biomarker discovery/validation, (4) Breast cancer and melanoma
Models	Isogenic cell culture models, in vivo models, particularly xenograft (syngenic/orthotopic)
Methods	Transcriptomics, proteomics, tissue microarrays, RNA interference, lentiviral transduction, non-invasive in vivo imaging (bioluminescence/biofluorescence, PET/CT)
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	GEE
First name	JULIA
Institution	Breast Cancer (Molecular Pharmacology) Group, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3NB, United Kingdom
Country
Phone	+44 29 20875226
E-mail	gee@cardiff.ac.uk
Website	http://www.cf.ac.uk/phrmy/researchcentres/Tenovus/index.html
Group leader since (year)	2000
Research interests	Historically our group (previously Tenovus Centre for Cancer Research) has undertaken research in the area of anti-hormone and anti-growth factor resistance in breast cancer through signal transduction/pharmacological challenge studies. Two of our key current research interests are (i) exploring very early anti-hormone-induced "compensatory" signal transduction that limits initial response, promotes cell survival and facilitates evolution of resistance and further features of progression (e.g. invasion). (ii) modelling and deciphering of signalling pathways altered as a consequence of long-term (>3yr) antihormone exposure (versus initial acquired resistance). A pervading goal in all our studies is to reveal new therapeutic targets to subvert resistance/progression and improve response, as well as providing new markers of therapeutic response & prognosis.
Models	In house panel of in vitro models derived from anti-hormone responsive ER+ HER2- and ER+ HER2+ breast cancer cells to reflect acquired resistance to various antihormones and erbB inhibitors, such as herceptin. Our recent studies extend into 3D cell culture.
Methods	Cell culture and signal transduction methodologies (including Western Blotting/PCR/reporter gene construct assays, pharmacological/antibody challenge) are core for candidate pathway studies as applied to our breast cancer models. My own areas of expertise lie in immunocytochemistry, notably using phosphospecific antibodies and their application to clinical material. I have also recently coordinated Affymetrix microarray studies as applied to our panel of cell lines that are revealing novel signalling elements induced during early drug treatment or elevated in established resistance. The relevance of these changes is subsequently being explored through functional studies, including employing SiRNA knockdown.
List of transgenic and KO mice available	No
Comments (including wish list)	Some of our cell lines are available for collaborative studies under MTA, and our Affymetrix mRNA profiling database can provide collaborators with an immediate indication of expression of their gene of interest in the acquired resistant model setting.
Last update	Tuesday, May 03, 2011

Last name	GLUKHOVA
First name	MARINA
Institution	UMR 144 CNRS-Institut Curie, Institut Curie, Centre de Recherche
Country
Phone	+33 1 42 34 63 31
E-mail	Marina.Glukhova@curie.fr
Website	http://www.curie.fr/equipe/327
Group leader since (year)	1995
Research interests	Cell-extracellular matrix interactions mediated by integrins in mammary development Wnt/ß-catenin signaling pathway in mammary tumorigenesis Stem/progenitor cells in the adult mouse mammary epithelium
Models	Transgenic mice, mouse models of human breast tumors, primary culture of mammary cells, mouse mammary cell lines
Methods	Isolation of mouse mammary epithelial cells, 2-D and 3-D cultures, transplantation into the cleared mammary fat pad, FACS, microarrays
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	GOMPEL
First name	ANNE
Institution	INSERM UMRS 938 Saint Antoine, Paris Paris Descartes University
Country	FRANCE
Phone	0033149284692/0033142348768
E-mail	anne.gompel@htd.aphp.fr
Website
Group leader since (year)
Research interests	human normal breast cells hormonedependency
Models	primary cultures of normal human cells xenografts of normal tissues in nude mice biopsies
Methods	QPCR, IHC, Western blots, si
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	GONZALEZ SUAREZ
First name	EVA
Institution	Bellvitge Institute for Biomedica Research (IDIBELL) Cancer Epigenetics and Biology Program (PEBC)
Country
Phone	34 932607500 Ext 3166
E-mail	egsuarez@idibell.cat
Website	http://www.pebc.cat/grupodetalle.php?idg=15
Group leader since (year)	2008
Research interests	Breast cancer and bone metastasis. RANK signaling. Tumor initiating cells. Mechanisms of resistance to current treatments. Inflammation and cancer.
Models	3D cultures, suspension cultures, primary cell cultures, orthotopic transplants of human and mouse tumors, transgenic and KO mouse models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, May 02, 2011

Last name	GRONER
First name	BERND
Institution	Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Str. 42, D-60596 Frankfurt am Main, Germany
Country
Phone	+49 69 63395180
E-mail	groner@em.uni-frankfurt.de
Website	http://www.georg-speyer-haus.de
Group leader since (year)	1982
Research interests	mammary gland biology, breast cancer, experimental therapeutics, cytokine signaling
Models	mammary gland reconstitution, genetically modified mammary stem cells, in vitro differentiation
Methods	cleared fat pad transplantation, lentiviral mediated transgenesis
List of transgenic and KO mice available	No
Comments (including wish list)	great initiative
Last update	Monday, September 29, 2008

Last name	HILKENS
First name	JOHN
Institution	Netherlands Cancer Institute
Country
Phone	+31 20 512 2018
E-mail	j.hilkens@nki.nl
Website	http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Ge...
Group leader since (year)	1982
Research interests	The aim of my laboratory is to identify and study novel genes involved in breast cancer and unravel the collaborating genetic pathways leading to breast cancer and breast cancer progression using mouse mammary tumor virus (MMTV) induced insertional mutagenesis in mouse models. genes of interest: R-spondin genes, Irs genes and membrane associated mucins (MUC1)
Models	various mouse models including K14-cre; p53f/f and MMTV cNeu transgenics
Methods	High throughput in vivo MMTV mediated insertional mutagenesis screens, protein biochemistry, retroviral transduction, in vivo tumorigeneicity and metastasis assay's
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	HOPKINS
First name	ANN
Institution	Royal College of Surgeons in Ireland
Country	IRELAND
Phone	+35318093858
E-mail	annhopkins@rcsi.ie
Website	http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=253&pip=team#...
Group leader since (year)	2005
Research interests	- Altered cell-cell and cell-matrix adhesion in breast cancer progression; - The role of junction adhesion molecule-A (JAM-A) in breast cancer invasion; - Lipid rafts as modulators of cell migration; - Breast progenitor cells
Models	Primary cultures of human breast tumours Tissue microarrays 3-dimensional cell culture models
Methods	Protein biochemistry Confocal microscopy Functional assays relevant to cell motility
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, November 05, 2009

Last name	HOWARD
First name	BEATRICE
Institution	Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London
Country
Phone	+ 44 (0) 207 153 5177
E-mail	beatrice.howard@icr.ac.uk
Website	http://www.breakthroughcentre.org.uk/research_groups/gene_function/bre...
Group leader since (year)
Research interests	mammary morphogenetic events with relevance to breast cancer etiology: Neuregulin3 (Nrg3) and Erbb4 signalling, embryonic mammary gland development, mammary lineage commitment and differentiation
Models	knockout and transgenic mice, ex vivo culture
Methods	general molecular, cellular and developmental biology techniques, qPCR, IF, ISH, protein analysis, microdissection, etc.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, August 25, 2008

Last name	HYNES
First name	NANCY
Institution	Friedrich Miescher Institute for Biomedical Research
Country
Phone	41 61 697 8107
E-mail	hynes@fmi.ch
Website	http://www.fmi.ch/hynes.n
Group leader since (year)	1981
Research interests	Breast cancer, ErbB family of receptor tyrosine kinases, mammary gland development, FGFRs, Wnt pathway, cell migration,
Models	Transgenic mammary tumor models, 4T1 mammary cancer model, human tumor xenograft models. mouse premature aging model
Methods	Protein analysis, migration, FACs, animal cancer models, etc
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	IGGO
First name	RICHARD
Institution	Bergonie Cancer Institute, University of Bordeaux
Country
Phone	00 33 5 56 33 04 23
E-mail	richard.iggo@me.com
Website	http://www.bergonie.org/fr/basic-research/richard-iggo.html
Group leader since (year)	1991
Research interests	Prediction of response to chemotherapy using gene signatures. Role of p53 in breast cancer. Quantitative transformation of normal mammary epithelial cells.
Models	Orthotopic xenografts in NOD/SCID mouse mammary glands.
Methods	Lentiviral infection of HMECs and BPECs to express oncogenes and inactivate tumour suppressor genes. Affymetrix expression and SNP chips from clinical samples.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Tuesday, December 08, 2009

Last name	JONKERS
First name	JOS
Institution	Netherlands Cancer Institute
Country
Phone	+31-20-5122000
E-mail	j.jonkers@nki.nl
Website	http://research.nki.nl/molbio/Groups/jonkers/jonkersgroup.htm
Group leader since (year)	2003
Research interests	BRCA1- and BRCA2-associated breast cancer, E-cadherin-mutated lobular breast cancer, inflammation and cancer, cancer stem cells, targeted anticancer therapeutics
Models	Conditional knockout and transgenic mice, in vitro cultures, orthotopic grafting models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	KAENEL
First name	PHILIP
Institution	Department for Clinical Research University of Bern
Country	SWITZERLAND
Phone
E-mail	philip.kaenel@dkf.unibe.ch
Website
Group leader since (year)
Research interests	Ephrin-B2 and EphB4 in mammary gland development
Models
Methods	Flow cytometry, in vivo assays, in vitro colony-forming and mammopshere assays, confocal microscopy
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	KLEIBL
First name	ZDENEK
Institution	Institute of biochemistry and experimental oncology, First faculty of medicine, Charles university in Prague
Country	CZECH REPUBLIC
Phone	+420 224965745
E-mail	zdekleje@lf1.cuni.cz
Website
Group leader since (year)
Research interests	breast cancer susceptibility (analysis of major predisposing genes, low penetrant genes and gene modifyers) in familial and sporadic breast cancer populations analysis of defects in DNA repair in mammary tumorigenesis (role of BRCA1 splicing variants in DSB repair kinetics) breast cancer pathogenesis (identification of somatic alterations in breast cancer lesions)
Models	genetic material from >500 high-risk families (HBC, HBOC, HOC), >500 sporadic BC patients, non cancer controls. Stable breast cancer cell lines (MCF-7, HCC1936, MBA-MB231, EM-G3 (derived from early progenitors)). Primary MEC from BRCA1 mtation carriers and controls.
Methods	Genotyping: HRM, dHPLC, PTT, MLPA, sequencing, fragment analysis. In vitro studies: Stable transfections, RNAi, qPCR, FL microscopy, WB Ex vivo studies: arrays (Phalanx), ms-MLPA, genotyping
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, February 17, 2011

Last name	KRESS
First name	CLEMENCE
Institution	Institut National de la Recherche Agronomique (INRA)
Country
Phone	+33 (0) 1 34 65 25 54
E-mail	Clemence.Kress@jouy.inra.fr
Website	http://w3.jouy.inra.fr/unites/gpl/index.shtml
Group leader since (year)
Research interests	The unit works on genomics and physiology of lactation: hormonal signalisation, gene expression control, synthesis of milk components, membrane traffic, endo/exocytosis pathways.
Models	Rabbit, cattle and mouse mammary gland tissue.
Methods	Cryosections of mammary tissue for DNA, RNA FISH, IF. Preservation of nuclear structure, confocal microscopy, 3D reconstitution and modelling
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, August 25, 2008

Last name	MARTIN
First name	STEWART
Institution	University of Nottingham, School of Molecular Medical Sciences, Department of Clinical Oncology, Nottingham City Hospital, Nottingham NG5 1PB
Country	UNITED KINGDOM
Phone	+44(0)1158231846
E-mail	stewart.martin@nottingham.ac.uk
Website	http://www.nottingham.ac.uk/mol/people/stewart.martin
Group leader since (year)	2000
Research interests	Prognostic and predictive biomarkers; Proteases (Calpains and Calpastatin); REDOX metabolism (biomarkers and novel inhibitors); Lymphatic cell biology (lymphovasular invasion);Radiation Biology (predictive biomarkers of radiotheraputic response, drug/radiation interactions).
Models	In vitro models (2D and 3D (matrigel)) with normal and malignant cells +/- stromal interactions; vascular and lymphatic endothelium (primary and established lines); tissue microarrays (histopathology based studies).
Methods	In vitro: invasion (incl endothelial transmigration), adhesion and migration (haplotaxis); usual molecular techniques (Westerns, Q-RT-PCR, si- & shRNA etc); Immunohistochemistry; Cell X-ray irradiation facility (+/- hypoxia)
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, December 01, 2011

Last name	OREND
First name	GERTRAUD
Institution	INSERM U682, De l`homéostasie tissulaire au cancer et à l`inflammation Equipe: Impact du microenvironnement sur l`angiogenèse et l`invasion tumorale
Country	FRANCE
Phone	33 (0)3 88 27 53 55
E-mail	gertraud.orend@inserm.u-strasbg.fr
Website	http://u682-inserm.u-strasbg.fr
Group leader since (year)	2002
Research interests	Extracellular matrix in tissue homeostasis, inflammation, angiogenesis, metastasis, stem cells, tenascin-C, laminins
Models	3D cultures, ex vivo culture models (HMECs...), transgenic and KO tenascin-C and laminin-111 mice
Methods	cell culture assays, BiAcore, biochemistry (western blot, IP, QPCR..), tissue analysis
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, November 19, 2009

Last name	ORIAN-ROUSSEAU
First name	VÉRONIQUE
Institution	Karlsruhe Institute of Technology, Institute for Toxicology and Genetics
Country
Phone	+497247826523
E-mail	veronique.orian-rousseau@kit.edu
Website	http://itgmv1.fzk.de/itg/orian-rousseau/orian-rousseau.html
Group leader since (year)	2003
Research interests	Molecular mechanisms involved in tumor progression, Receptor Tyrosine Kinases (EGFR, c-Met, VEGFR..) activation and internalisation, Cell Adhesion Molecules (in particular CD44, ICAM), Role of CD44 in Breast Cancer Stem cells, Signal Transduction
Models	CD44 knock out, Xenograft, pancreas orthotopic models
Methods	KO technology, Transgenic, Angiogenesis assays,
List of transgenic and KO mice available	Yes
Comments (including wish list)	CD44 floxed mice
Last update	Wednesday, December 02, 2009

Last name	PAGES
First name	GILLES
Institution	University of Nice Sophia Antipolis UMR CNRS 6543
Country
Phone	00 33 4 92 03 12 31
E-mail	gpages@unice.fr
Website
Group leader since (year)	1999
Research interests	Normal and tumor angiogenesis. We are looking at the regulation of angiogenic factor VEGf and IL-8 in particular at the post transcriptional level. We are studying mRNA binding protein that destabilizes the mRNA. We are looking at the loss of mRNA degradative protein in breast cancer on tumor cell lines and on tumor samples. We are also looking at the effect of targetted therapy on the expression of these proteins
Models	Cell with different metastatic potential with inducible expression of mRNA degradative protein, tumor samples
Methods	Stable and transient transfection of genes of interest. In vivo imaging of tumor xenografts of cells with expression of luciferase. Determination of angiogenic factor by ELISA; Reporter genes (promoters and 3'UTR)
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	PELICCI
First name	PIER GIUSEPPE
Institution	Experimental Oncology European Institute of Oncology and the Campus IFOM-IEO
Country
Phone	0039-02-57489831
E-mail	piergiuseppe.pelicci@ifom-ieo-campus.it
Website	http://www.ifom-ieo-campus.it/
Group leader since (year)	1987
Research interests	1.Hematopoietic stem cells and Acute Myeloid Leukemias 2. Breast stem cells and breast cancer 3.Effects of checkpoint activation on tissue homeostasis and molecular mechanisms of aging 4. Epigenetics and environmental cancer risk assessment
Models	Mammospheres; KO and transgenic mice, humanized mouse, conditional and constitutive models
Methods	Cell culture (primary cell culture; cell lines) and mouse models; 3D cultures; xenografts; standard molecular and cell biology techniques; time-lapse microscopy; FACS sorting; siRNA technology; DNA microarrays, tissue microarrays; ChIP, ChIP-chip and ChIP-Seq.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, December 17, 2009

Last name	PIETERSEN
First name	ALEXANDRA
Institution	National Cancer Centre Singapore & Duke-NUS Graduate Medical School
Country	SINGAPORE
Phone	+65 6223 7241
E-mail	apietersen@gmail.com
Website	www.pietersenlab.com
Group leader since (year)	2008
Research interests	Regulation of the mammary stem cell hierarchy and its relation to breast cancer. We use mouse models to investigate the role of proto-oncogenes in regulation of stem cells, lineage restriction and differentiation. We have a particular interest in the role of epigenetic modifiers in these processes.
Models	transgenic mice (KO, GFP reporters and conditional transgenes for various oncogenes)
Methods	multiparameter flow cytometry, cleared fat pad transplantation, in vitro colony-forming & differentiation assays, mouse models of breast cancer, histology and (wholemount) fluorescence imaging
List of transgenic and KO mice available	No
Comments (including wish list)	Note that European candidates will be eligible to apply for an EMBO fellowship to work in this lab
Last update	Thursday, December 01, 2011

Last name	RIETHDORF
First name	SABINE
Institution	Institute of Tumor Biology, University Medical center Hamburg-Eppendorf, Germany
Country
Phone	0049-40-42803-2628
E-mail	s.riethdorf@uke.uni-hamburg.de
Website	http://www.uke.uni-hamburg.de/institute/tumorbiologie
Group leader since (year)	>10
Research interests	Disseminated and circulating tumor cells in bone marrow and blood, molecular and phenotypical characterization of DTC, CTC, breast cancer, stem cells
Models
Methods	Enrichment, detection and characterization of DTC, CTC, automatic detection systems, in situ hybridization (DNA; RNA)
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, August 25, 2008

Last name	RIO
First name	MARIE-CHRISTINE
Institution	Institut de Génétique et de Biologie Moléculaire et Cellulaire
Country
Phone	0388653424
E-mail	rio@igbmc.u-strasbg.fr
Website
Group leader since (year)	1989
Research interests	Molecular biology of breast cancers. Normal and pathological function of few genes: pS2/TFF1, ST3/MMP11, MLN64, MLN51 and TRAF4, all cloned in the laboratory. Proteomic of breast cancers
Models	Knock-out mice for the genes cited above. Several models of tumorigenesis in mice
Methods	Cellular and molecular biology Transgenic mice
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	ROTTENBERG
First name	SVEN
Institution	The Netherlands Cancer Institute
Country
Phone	+31 20 5122082
E-mail	s.rottenberg@nki.nl
Website
Group leader since (year)
Research interests	mouse models for anti-cancer drug resistance
Models	K14-cre, Brca1F/F, p53F/F Ref.: Liu et al., PNAS 104, 12111-12116, 2007 Rottenberg et al., PNAS 104, 12117-22, 2007
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, August 25, 2008

Last name	SAHAI
First name	ERIK
Institution	Cancer Research UK
Country	UNITED KINGDOM
Phone
E-mail	erik.sahai@cancer.org.uk
Website
Group leader since (year)	2004
Research interests	Invasion and metastasis Tumour Microenvironment Cancer associated fibroblasts
Models	Cell lines - 4T1, MDAMB231, MDAMB468, MTLn3E Mouse model - MMTV-PyMT
Methods	Organotypic cultures Intravital imaging
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Tuesday, February 22, 2011

Last name	SCHMITT
First name	FERNANDO
Institution	IPATIMUP, Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias, s/n4200-465 PortoPortugalRua Dr. Roberto Frias, s/n
Country
Phone	+351-225570700
E-mail	fernando.schmitt@ipatimup.pt
Website	http://www.ipatimup.pt
Group leader since (year)	1995
Research interests	Breast cancer pathology; basal-like carcinomas; basal cell markers; P-cadehrin role in breast carcinogenesis: regulation and function; HER-2/EGFR-targeted therapy resistance; vitamin D effect in controlling breast cancer; PTEN role in breast cancer
Models	In vitro cell culture; breast cancer tissue series; tissue microarrays (TMAs); mice xenografts
Methods	Microscopy; immunohisto/cytochemistry; cell culture; western-blot; immunoprecipitation; siRNA technology; real-time PCR; cell invasion and aggregation assays; time-lapse microscopy; proteomics; cDNA cloning; luciferase-reporter assays
List of transgenic and KO mice available	No
Comments (including wish list)	None
Last update	Thursday, December 09, 2010

Last name	SCHOENENBERGER
First name	CORA-ANN
Institution	M.E. Müller Institute for Structural Biology Biozentrum University of Basel
Country	SWITZERLAND
Phone	0041812672096
E-mail	Cora-ann.schoenenberger@unibas.ch
Website
Group leader since (year)	1998
Research interests	cytoskeleton (cytoplasmic and nuclear actin), mechanobiology, mechanical properties of mammary cancer
Models	Cell culture (2D & 3D)
Methods	standard biochemical & molecular techniques, light- and electronmicroscopy, atomic force microscopy
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, October 20, 2010

Last name	SCHULER
First name	LINDA
Institution	University of Wisconsin--Madison
Country	UNITED STATES
Phone	001-608-263-9825
E-mail	schulerl@svm.vetmed.wisc.edu
Website
Group leader since (year)	long time
Research interests	hormonal contributions (especially prolactin) to the development, progression and therapeutic responsiveness of breast cancer
Models	human breast cancer cell lines, NRL-PRL transgenic mouse model
Methods	in vitro and in vivo
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	SIERRA
First name	ANGELS
Institution	IDIBELL
Country
Phone	34 93 2607429
E-mail	asierra@idibell.org
Website	http://www.idibell.org/
Group leader since (year)	1997
Research interests	Apoptotis, Breast cancer, Diagnostic markers, Metastasis pathogenesis, New diagnostic tools
Models	Metastatic variants from human breast carcinomas, Brain and lung metastasis models in nude mice, Primary cultures of metastatic cells
Methods	Bioinformatics, Cell biology, IHC, Proteomics, Tissue array
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	SLEEMAN
First name	JONATHAN
Institution	University of Heidelberg, Medical Faculty Mannheim, Ludolf-Krehl-Str 13-17, 68167 Mannheim, Germany and Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, 76021 Karlsruhe, Germany
Country
Phone	+49 621 383 9955
E-mail	sleeman@medma.uni-heidelberg.de
Website	http://www.ma.uni-heidelberg.de/inst/cbtm/mbio/
Group leader since (year)	1997
Research interests	Tumor metastasis, particularly the role of the lymphatic system in tumor dissemination, the role of cancer stem cells in metastasis and the microenvironment that supports metastatic growth
Models	Knockout and transgenic mice, transplantable syngeneic and xenograft tumor models, in vitro cell models
Methods	Animal technology, standard immunohistochemistry, molecular and cell biology techniques, primary cell culture, FACS sorting, microarray, in vitro metastasis assays, time lapse, cell encapsulation, synthetic organic chemistry, various immunoassays, yeast 2 hybrid, confocal, whole mounts, etc
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	SMALLEY
First name	MATT
Institution	European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff
Country
Phone
E-mail	SmalleyMJ@Cardiff.ac.uk
Website
Group leader since (year)	2006
Research interests	Stem cells in normal and neoplastic mammary epithelium; control of self-renewal and differentiation in mammary stem cells
Models	In vivo mouse mammary gland
Methods	Harvest of primary mouse mammary epithelium; multicolour flow cytomtery; cleared fat pad transplantation; qPCR
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, December 01, 2011

Last name	SMITH
First name	GILBERT
Institution	National Cancer Institute
Country	UNITED STATES
Phone	1-0-301-496-2385
E-mail	gs4d@nih.gov
Website	http://ccr.cancer.gov/staff/staff.asp?profileid=5602
Group leader since (year)	1970
Research interests	Mammary gland development, stem cell hierarchy in epithelium, growth senescence, cancer, mutations relevant to mammary epithelial transformation
Models	CzechII mice (no MMTV provirus in genome); WAPCre/Rosa26flox-STOP-flox-lacZ model, reprogramming non-mammary cells in mouse mammary glands during outgrowth
Methods	Tissue culture Transplantation Microscopy
List of transgenic and KO mice available	No
Comments (including wish list)	Not in Europe but happy to connect and collaborate/consult with members of this group...
Last update	Wednesday, January 05, 2011

Last name	SONNENBERG
First name	ARNOUD
Institution	The Netherlands Cancer Inst.
Country
Phone	31-20-5121942
E-mail	a.sonnenberg@nki.nl
Website
Group leader since (year)	1990
Research interests	Role of laminin-binding integrins and associated proteins in mammary gland development, mammary differentiation and tumorigenesis. Hemidesmosomes, integrin signaling, diagnostic markers for mammary gland development and stem cells in normal and neoplastic epithelium
Models	Conditional knockout mice for the integrin alpha3 (Iga3), beta4 (Itgb4) and the tetraspanin CD151.
Methods	Microscopy, immunohistochemistry, cell culture, protein biochemistry, KO and transgenic mice, etc.
List of transgenic and KO mice available	No
Comments (including wish list)	None
Last update	Monday, September 29, 2008

Last name	STEIN
First name	TORSTEN
Institution	Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Country
Phone	+44 (0)141 211 1942
E-mail	Torsten.Stein@glasgow.ac.uk
Website	http://www.gla.ac.uk/departments/cancersciences/pathologyandgeneregula...
Group leader since (year)	2006
Research interests	mammary gland development; involution; terminal end buds; breast cancer development. We are trying to identify and characterise novel pathways that are involved or control key stages of mammary gland development, and that may be deregulated in breast cancer. Particular genes of interest: Annexin A8, Reelin, TSC-22.
Models	normal mouse; TSC-22D1i2 transgenic mice
Methods	microarrays, IF, IHC, standard cell and molecular biology
List of transgenic and KO mice available	No
Comments (including wish list)	none
Last update	Friday, September 17, 2010

Last name	STINGL
First name	JOHN
Institution	Cancer Research UK Cambridge Research Institute
Country	UNITED KINGDOM
Phone	44 1223 404 353
E-mail	john.stingl@cancer.org.uk
Website	http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/stinglj/...
Group leader since (year)	2008
Research interests	Mouse and human mammary gland stem cells. Basal-like breast cancer. Mechanisms of resistance to anti-estrogen therapies
Models
Methods	In vivo mammary stem cell assays. In vitro colony forming assays. Flow cytometry
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Tuesday, March 03, 2009

Last name	STREULI
First name	CHARLES
Institution	University of Manchester
Country
Phone	+44 161 27 5626
E-mail	cstreuli@manchester.ac.uk
Website	http://www.breastcentre.manchester.ac.uk/
Group leader since (year)	1991
Research interests	normal mammary gland development and function; integrins and integrin signalling; extracellular matrix; apoptosis; inhibitor-of-apoptosis-proteins; early breast cancer
Models	primary mammary cell cultures; mammary-specific gene deletion in vivo and culture
Methods	primary cell culture; 3D culture; 3D immunstaining; gene deletion in vivo with mammary-specific Cre; gene deletion in primary culture with 4-OHT (CreER) or viral infection with adenoCre; apoptosis methods; siRNA oligos, shRNA vectors and shRNA lentiviruses
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	SWARBRICK
First name	ALEX
Institution	Garvan Institute of Medical Research
Country	AUSTRALIA
Phone	+61-2-9295-8366
E-mail	alex.swarbrick@gmail.com
Website	http://www.garvan.org.au/about-us/our-people/dr-alex-swarbrick
Group leader since (year)	2007
Research interests	Stem cell pathways in mammary development, breast cancer and metastatic progression. MicroRNAs in cancer progression. Inhibitor of Differentiation proteins, Id1, Id2, Id3, Id4 Hedgehog pathway in breast cancer. Development of novel therapeutics / biomarkers for therapeutic response to existing agents
Models	Chimeric (transplant) Mouse models of mammary development and cancer. ID1- and ID4- GFP knock-in mice. LSL-SmoM2 and Ptc-LacZ knockin mice. C3-SV40 Large T transgenic. Cell lines in vivo: Comma-d-b, 4T1, M6, MDA-MB-231
Methods	In vivo and in vitro stem and progenitor assays. In vivo imaging. Inducible gene expression and knockdown
List of transgenic and KO mice available	Yes
Comments (including wish list)
Last update	Monday, November 29, 2010

Last name	VAN DE WATER
First name	BOB
Institution	Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
Country
Phone	31 71-5276223
E-mail	b.water@lacdr.leidenuniv.nl
Website
Group leader since (year)	1999
Research interests	Role of cell-ECM signaling in mammary gland development and breast cancer development and progression/metastasis. Integrated signaling between receptor protein tyrosine kinase and focal adhesion kinase (FAK). FAK-mediated signaling.
Models	Conditional knockouts for FAK and p53. Mammary gland reconstitution models. Orthotopic breast tumor/metastasis models. 2D and 3D migration/invasion models. 3D branching morphogenesis models. Models for focal adhesion dynamics.
Methods	siRNA and shRNA libraries. Retro- and lenti-viral transduction of MMEC and breast tumor cell lines. 2D and 3D MEC cultures. Live cell imaging (spectral imaging, TIRF microscopy, confocal, DIC) followed by quantitative image analysis. Fluorescence and bioluminescence analysis of breast cancer progression. Conditional expression of DN and DA target genes in orthotopic breast tumor models. Intravital imaging of breast tumor cell migration in primary tumor. Gene expression profilling.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	VAN LOHUIZEN
First name	MAARTEN
Institution	The Netherlands Cancer Institute
Country
Phone	+31-20-5122030
E-mail	m.v.lohuizen@nki.nl
Website	http://research.nki.nl/lohuizenlab/
Group leader since (year)	1995
Research interests	We study epigenetic gene regulation and transcriptional repression by Polycomb-group (Pc-G) protein complexes, and the effects of deregulation of Pc-G genes on development, Cell cycle control, cancer formation and stem cell maintenance. In addition, we are performing large-scale genetic screens in primary cells and in cancer-predisposed mice to identify cancer-relevant combinations of collaborating oncogenes and tumor-suppressor genes.
Models	Diverse animal models: Bmi1 KO and conditional KO mice; EZH2 conditional KO mice, RNF2 conditional KO mice;Tissue-specific inducible Bmi1 transgenic mice;MMTV-Wnt1; MMTV-NEU; MMTV-Myc;
Methods	mouse and human ES cell technologies, fat pad transplantation, 2D MEC culture, protein biochemistry, high content screening, lentiviral or retroviral transduction, stem cell FACS sorting, DAMid chromatin profiling, High throughput in vivo retroviral insertional mutagenesis screens
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	VAN RHEENEN
First name	JACCO
Institution	Hubrecht Institute
Country	NETHERLANDS
Phone	+31 (0)30-2121905
E-mail	j.vanrheenen@hubrecht.eu
Website	http://www.niob.knaw.nl/research/vanrheenen/index.html
Group leader since (year)	2008
Research interests	Complication of metastasis, the process in which cells detach from the primary tumor to form new distant tumor sites, is the primary reason why women die from breast cancer. The metastatic behavior of tumor cells is highly dependent on the cell’s intrinsic characteristics and on the tumor microenvironment, such as stromal cells and the extracellular matrix. We study both by combining conditional mouse models that recapitulate human breast tumors and intravital imaging techniques (high resolution imaging of metastasis in living animals in real time). By these experiments we hope to indentify new drug targets that combined with current clinical approaches may lead to new therapies.
Models	allograft tumor models:1) Ola/FVB mice with Kep1_11 cells (Cdh-/-;Trp53-/-, Derksen et al, Canc Cell 2004)2) BalbC with 4T1 cell line. Genetic model:MMTV-Neu tumor model
Methods	Our lab studies the behavior of metastasizing tumor cells inside living mice by intravital imaging; the imaging of living tissue. Whole mice bearing metastasizing tumors are imaged at subcellular resolution by confocal or two-photon microscopy. Our lab, together with the labs of Drs Segall and Condeelis (Albert Einstein College of Medicine, Bronx, NY, USA) has developed a mammary gland imaging window in order to image and track cells for multiple days inside mammary tumors in living mice. Moreover, we use intravital FRET imaging to study activity of several signaling pathways inside metastasizing tumor cells.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	VANHAESEBROECK
First name	BART
Institution	Centre for Cell Signalling - Institute of Cancer - Barts and the London Medical School -
Country
Phone	00-44-207-882-8201
E-mail	bart.vanh@qmul.ac.uk
Website	http://www.cancer.qmul.ac.uk/research/cell_signalling/
Group leader since (year)	1998
Research interests	Signal transduction - cancer and inflammation
Models	mouse models - knock-in gene-targeting - PI 3-kinase and related pathways
Methods	standard cell and molecular biology - biochemistry - mass spectrometry
List of transgenic and KO mice available	No
Comments (including wish list)	special interest in cancer and inflammation, in relation to breast cancer
Last update	Monday, September 29, 2008

Last name	VELTMAAT
First name	JACQUELINE
Institution	A*STAR Institute of Molecular and Cell Biology
Country	SINGAPORE
Phone	+65 6586 9618
E-mail	jmveltmaat@imcb.a-star.edu.sg
Website	http://www.imcb.a-star.edu.sg/php/jv.php
Group leader since (year)	2006
Research interests	- molecular regulation of embryonic phase of mammary gland development (in particular induction) as well as postnatal morphogenesis and differentiation - creation of software for image analysis
Models	mouse mutants
Methods	histology, RNA-RNA in situ hybridization and immunochemistry on whole mount and sectioned embryos, tissue separation and recombination, organ culture, transplantation, micro-array
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, July 08, 2010

Last name	VENEZIANI
First name	BIANCA MARIA
Institution	Dipartimento di Biologia e Patologia Cellulare e Molecolare Facoltà di Medicina e Chirurgia Università di Napoli "Federico II"
Country	ITALY
Phone	390817463758
E-mail	bianca.veneziani@unina.it
Website	http://www.dbpcm.org/cms/
Group leader since (year)	2000
Research interests	Human breast cancer, steroid receptors, signalling and stem cells. Mechanisms of resistance to current treatments. Stromal and adipose tissue of the mammary gland.
Models	Breast cancer epithelial-stromal co-cultures, mammospheres.
Methods	Primary cell culture, breast cancer cell lines, in vitro analysis of the tumor-stroma interaction, cryopreservation, qPCR, FACS, stem cell sorting, RNA and protein analyses.
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Friday, January 29, 2010

Last name	VIVANCO
First name	MARIA
Institution	CIC bioGUNE, Cell Biology and Stem Cells Unit, Bilbao, SPAIN
Country
Phone	+34 94 406 1322
E-mail	mdmvivanco@cicbiogune.es
Website	http://www.cicbiogune.es/
Group leader since (year)	1997
Research interests	Steroid hormone receptors, human mammary gland, breast cancer, stem cells, regulation of self-renewal and differentiation in human breast stem cells
Models	human mammary epithelial cells (normal and tumour)
Methods	primary cultures, 2D and 3D cultures, FACS, qPCR, multiplex RT-PCR, confocal microscopy, general molecular and cellular biology techniques
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, December 01, 2011

Last name	WAKEFIELD
First name	LALAGE
Institution	National Cancer Institute
Country	UNITED STATES
Phone	+1-301-496-8351
E-mail	lw34g@nih.gov
Website	http://ccr.cancer.gov/staff/staff.asp?profileid=13665
Group leader since (year)	1989
Research interests	TGF-beta pathway in mammary gland development and neoplasia. Development of TGF-beta path targeted therapeutics. Metastasis. Breast cancer stem cells.
Models	Human xenograft, mouse syngeneic transplant, genetically engineered mouse breast cancer models
Methods	Transcriptomics, Chip-Chip/Seq, RNAi, confocal microscopy, transgenesis, ex vivo metastasis assays, immunophenotyping, techniques for quantitative analysis of TGF-beta pathway
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Thursday, November 11, 2010

Last name	WATSON
First name	CHRISTINE
Institution	University of cambridge
Country
Phone	+44 1223 333725
E-mail	cjw53@cam.ac.uk
Website	http://www.path.cam.ac.uk~madgroup
Group leader since (year)
Research interests
Models
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	WHITELAW
First name	BRUCE
Institution	Roslin Institute and Royal (Dick) School of Veterinary Studies Univeristy fo Edinburgh Roslin Midlothian EH25 9PS, UK
Country
Phone	+44-(0)131-527-4200
E-mail	bruce.whitelaw@rolsin.ed.ac.uk
Website
Group leader since (year)	1994
Research interests	gene transfer gene expression systems cancer stem cell biology mammary growth and development
Models	transgenic mice transgenic sheep and pigs
Methods	general molecular biology
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Monday, September 29, 2008

Last name	WIESMÜLLER
First name	LISA
Institution	Gynaecological Oncology, Head Department of Obstetrics and Gynaecology of the University of Ulm
Country	GERMANY
Phone	+49-(0)731-500-58800/58801
E-mail	lisa.wiesmueller@uni-ulm.de
Website	http://www.uni-ulm.de/klinik/ufk/cms/html/forschung_gyn-onko.htm
Group leader since (year)	2001
Research interests	apoptosis breast cancer risk chemoprevention DNA double strand break repair homologous recombination replication fork stalling prediction of therapeutic responsiveness
Models	- patient cell lines - peripheral lymphocytes, fibroblasts, and primary epithelial cells from mammary gland of probands/patients - MEFs from mice differing in breast cancer susceptibilities
Methods	- analysis of distinct DNA double strand repair pathways - nuclear foci analysis for DNA damage/repair factors - apoptosis analyses - characterization of genotoxic, chemopreventive, and therapeutic agents agents
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, January 05, 2011

Last name	WOOD
First name	TERRI
Institution	New Jersey Medical School Cancer Center/UMDNJ
Country	UNITED STATES
Phone	973-972-6529
E-mail	woodte@umdnj.edu
Website	http://njmsuhcc.umdnj.edu/home/index.php/Wood-Lab.html
Group leader since (year)	1993
Research interests	Mammary/breast development and cancer, insulin-like growth factors, stem cells, signaling pathways
Models	Transgenic/KO mice, in vitro non-adherent mammospheres
Methods
List of transgenic and KO mice available	No
Comments (including wish list)
Last update	Wednesday, July 20, 2011

Last name	YOUNG
First name	LEONIE
Institution	Royal College of Surgeons in Ireland
Country	IRELAND
Phone	+35314028576
E-mail	lyoung@rcsi.ie
Website	http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=35&pip=pubs#t...
Group leader since (year)	2001
Research interests	- Coactivator proteins in endocrine-resistant breast cancer - Identification of biomarkers to predict endocrine-sensitivity and endocrine-resistance in breast cancer patients
Models	Breast cancer patient primary cultures Tissue microarrays Murine tumour models
Methods	Immunohistochemistry In situ FRET CHIP-Seq Transcription factor binding
List of transgenic and KO mice available	Yes
Comments (including wish list)
Last update	Thursday, November 05, 2009