EUROPEAN NETWORK OF BREAST DEVELOPMENT AND CANCER LABS
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LIST OF EUROPEAN LABS WORKING IN THIS RESEARCH AREA:
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Last name BENTIRES-ALJ
First name MOHAMED (MOMO)
Institution Friedrich Miescher Institute for Biomedical Research (FMI)
Country SWITZERLAND
Phone + 41 (0) 61 69 74048
E-mail Bentires@fmi.ch
Website http://www.fmi.ch/bentires-alj.m
Group leader since (year) 2006
Research interests Breast development and cancer, protein tyrosine phosphatases, epithelial-stroma interactions, stem cells, 11q13 amplification, signaling
Models 3D cultures, ex vivo culture models (HMECs...), xenograft, KO and transgenic mice, humanized mouse
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
none
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Yes
Last update
Thursday, January 08, 2009
 
Last name BIRNBAUM
First name DANIEL
Institution Centre de Recherche en Cancérologie de Marseille, UMR599 Inserm and Institut Paoli-Calmettes
Country
Phone 33 4 91 75 84 07
E-mail birnbaum@marseille.inserm.fr
Website http://crcm-en.marseille.inserm.fr/
Group leader since (year) 1987
Research interests Molecular Oncology, Oncogenomics, Breast cancer, Leukemia, Colon cancer, Tyrosine kinases, Oncogenes, Prognosis markers, Mitosis, Centrosome.
Models Human pathologies, cell lines, mouse models.
Methods DNA microarrays, array-CGH, FISH, sequencing, tissue microarrays, videomicroscopy, confocal microscopy, transgenesis, xenografts.
List of transgenic and KO
mice available
No
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No
Last update
Monday, September 29, 2008
 
Last name BONIZZI
First name GIUSEPPINA (GIUSY)
Institution European oncology institute (IEO)
Country
Phone +390257489396
E-mail giuseppina.bonizzi@ifom-ieo-campus.it
Website
Group leader since (year)
Research interests Breast Stem cell and Breast cancer stem cell
Models 3D cultures, xenograft, KO and transgenic mice, humanized mouse
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
none
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Yes
Last update
Monday, August 25, 2008
 
Last name BØRRESEN-DALE
First name ANNE-LISE
Institution Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
Country
Phone +47 22 78 13 73
E-mail a.l.borresen-dale@medisin.uio.no
Website http://www.radium.no/genetics/
Group leader since (year) >20 years
Research interests The Department's Research vision is exploring The Systems Biology of Breast Cancer Our research program is focusing on the molecular biology of breast and ovarian cancer with emphasis on identification of genotypes and gene expression profiles contributing to elevated cancer risk, radiation sensitivity, tumor aggressiveness and therapy resistance. The hypothesis is that both the geno- and phenotype of the tumor as well as the patients own genotype (the genetic “makeup” of the patient constituted by both high and low penetrance genes) play a role in breast and ovarian cancer risk, in the type of cancer developed, the disease course and the response to treatment. The results may be used to identify high-risk individuals that may benefit from preventing strategies, and to individualize the treatment of patients with respect to choice of drugs as well as to dose and duration. This may give a better therapeutic effect and less adverse reactions in the individual patient. Goals: 1. To join forces and expertise to create a world-leading Breast Cancer Research Center including The Dept of Medical Statistic Faculty of Medicine, Dept of Informatics, Faculty of Mathematics and Natural Sciences, UiO, The Norwegian Radium Hospital, Ullevål Univ. Hospital and potentially other hospitals in the Oslo area 2. To follow the linear time course of predisposition, initiation, early stages and advanced disease and to dissect the molecular mechanisms triggered at each stage 3. To follow the multidimentional interactions at various levels in a systems biology approach
Models large cohorts of breast cancer patients with long term follow up, and healty woman participating in a population based study NOWAC http://uit.no/kk/NOWAC/
Methods large scale analyses using various array technology to perform WGA on SNPs and CNVc, blood expression (mRNA and miRNA), Tumor mRNA and miRNA expression, aCGH, mutation, methylation and protein anaalyses using RPPA
List of transgenic and KO
mice available
No
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Yes
Last update
Tuesday, July 20, 2010
 
Last name BRACKE
First name MARC
Institution Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Country
Phone +32 9 332 3007
E-mail brackemarc@hotmail.com
Website http://www.ugent.be/people?ugentid=801000436153
Group leader since (year) 2003
Research interests Mechanisms of tumor invasion and metastasis, mammary cancer, stromal interactions with cancer cells (myofibroblasts, adipocytes and stem cells), cytoskeleton and motility, cadherin/catenin complexes in cell-cell adhesion, endoplasmic reticulum stress, radiation-induced effects on invasion, new circulating tumor markers, invasion suppressor genes, early metastasis genes, hormones and breast cancer.
Models 3D-models for invasion in vitro (embryonic chick heart, type I collagen, Matrigel, reconstituted tissues), metastasis models in laboratory mice, aggregation models for cell-cell adhesion, interaction models between stromal and cancer cells, directional migration models (wound healing, checker board analysis, radial aggregate outgrowth).
Methods Organotypic confronting cultures for invasion, Western blot, immunoprecipitation, transfection, siRNA, time-lapse microscopy, immunohisto/cytochemistry, raising monoclonal antibodies, ELISA, assays for ER stress and apoptosis, cell irradiation, PCR…
List of transgenic and KO
mice available
No
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No
Last update
Monday, September 29, 2008
 
Last name BRAGA
First name VANIA
Institution Molecular Medicine, NHLI, Faculty of Medicine Imperial College London
Country
Phone +44 20 7594-3233
E-mail v.braga@imperial.ac.uk
Website
Group leader since (year) 1996
Research interests epithelial polarization and differentiation, signalling from cell-cell adhesion receptors, small GTPases, cell-cell adhesion, cadherin receptors, morphological transformation, cancer cell biology
Models primary cultures of keratinocytes, cell lines
Methods microinjection, microscopy, RNAi, RNAi screen, protein-protein interaction, cell-cell adhesion assays, yeast two-hybrid, Q-PCR. intracellular trafficking assays
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name BRISKEN
First name CATHRIN
Institution Swiss Institute for Experimental Cancer Research (ISREC) School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL)
Country SWITZERLAND
Phone 41-21-6925851
E-mail cathrin.brisken@epfl.ch
Website http://www.nccr-oncology.ch/scripts/index.aspx?idd=85
Group leader since (year) 2001
Research interests Mammary gland development, breast cancer, hormone action, intercellular communication, morphogenesis
Models mouse mutant strains, primary human breast epithelial cells
Methods tissue recombinations techniques, primary cultures of mouse and human breast epithelial cells, retro and lentiviral infections
List of transgenic and KO
mice available
No
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Yes
Last update
Sunday, January 11, 2009
 
Last name BUESS
First name MARTIN
Institution Department of Research
Country
Phone 0041 61 265 50 74
E-mail mbuess@uhbs.ch
Website
Group leader since (year) 2005
Research interests Understanding the pathophysiology of breast cancer gene expression profiles by in vitro analysis of the tumor-stroma interaction
Models
Methods primary cell culture, breast cancer cell lines, qPCR, HEEBO microarrays, FACS, standard molecular and cell biology techniques
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name CALDAS
First name CARLOS
Institution Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge
Country
Phone +44(0)1223 404420
E-mail cc234@cam.ac.uk
Website http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/caldasc/...
Group leader since (year) 1997
Research interests Breast cancer Genomics Cancer stem cells microRNA Oncogenes and tumor supressor genes 8p12
Models Cell lines Human breast cancers Mouse models
Methods Expression microarrays Array-CGH Bioinformatics Tissue microarrays Xenografts Mammosphere assay
List of transgenic and KO
mice available
No
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Last update
Monday, September 29, 2008
 
Last name CHARIOT
First name ALAIN
Institution Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry Unit, University of Liege, Belgium
Country
Phone 32 4 366 24 72
E-mail alain.chariot@ulg.ac.be
Website http://www.chimmed.ulg.ac.be
Group leader since (year) 2005
Research interests Insight into the NF-kB and IRF-activating signaling pathways: Elucidation of the TBK1/IKKe-dependent cascades in vivo. Insight into their deregulations in breast cancer.
Models We are currently generating a transgenic model for IKKe
Methods Yeast-two hybrid, micro-array analyses, ChIP assays, kinase assays, IPs, Real-time PCRs.
List of transgenic and KO
mice available
No
Comments
(including wish list)
We are interested in exploring the oncogenic potential of two kinases, TBK1 and IKKe, by extending our knowledge from the molecular level to an in vivo model.
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Yes
Last update
Monday, September 29, 2008
 
Last name CINTI
First name SAVERIO
Institution Section of Anatomy, Dept. of Molecular Patholgy and Innovative Therapies, School of Medicine, University of Ancona (Politecnica delle Marche), Ancona, Italy
Country
Phone +39 0712206088
E-mail cinti@univpm.it
Website http://www.univpm.it/Entra/Engine/RAServePG.php/P/320710012049/idsel/3...
Group leader since (year) >20
Research interests Adipose organ. Adipose tissue of the mammary gland. Interaction between epithelial cells in mammary gland and adipocytes. White adipose tissue. Brown adipose tissue. Transdifferentiation.
Models
Methods Light microscopy. Immunohistochemistry. Immunocytochemistry. Confocal microscopy. Electron microscopy. LacZ and GFP mice. Morphometry. Micro-dissection. Whole mount tissue embedding, adipose cell culture
List of transgenic and KO
mice available
No
Comments
(including wish list)
Our data support the reversible transdifferentiation of milk secretory epithelial cells into adipocytes in the mammary gland. PNAS, 101, 48, 16801-16806, 2004; In vivo physiological transdifferentiation of adult adipose cells, De Matteis R, Zingaretti MC, Murano I, Vitali A, Frontini A, Giannulis I, Barbatelli G, Marcucci F, Bordicchia M, Sarzani R, Raviola E, Cinti S, Stem Cells. 2009 Nov;27(11):2761-8.
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Yes
Last update
Thursday, May 06, 2010
 
Last name CLARKE
First name ROB
Institution University of Manchester
Country
Phone 44-(0)161-446 3210
E-mail robert.clarke@manchester.ac.uk
Website http://www.breastcentre.manchester.ac.uk/
Group leader since (year) 2003
Research interests Human breast cancer, normal breast tissue, steroid receptors, signalling and stem cells
Models Primary human breast tissue xenografts and 3D breast cell culture: matrigel and mammospheres
Methods FACS and MACS for stem cell enrichment. RNA and protein analyses.
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name CLARKSON
First name RICHARD
Institution University of Cardiff School of Biosciences
Country
Phone +2920 870249
E-mail clarksonr@cf.ac.uk
Website http://www.cardiff.ac.uk/biosi/research/genetics/index.html
Group leader since (year) 2005
Research interests involution, apoptosis, programmed cell death, transcription factors, signaling, development, cancer
Models mouse and human, normal and cancer cell lines mouse primary cell culture conditional KO and conditional transgenics mouse transgenic models of BC
Methods chIP, microarrays, MRI, transgenesis, QPCR, immunodetection
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name COOMBES
First name R CHARLES
Institution Imperial College
Country
Phone 020 8383 5828
E-mail c.coombes@imperial.ac.uk
Website http://www.imperial.ac.uk/medicine/sora
Group leader since (year) 20+
Research interests I run a laboratory of approximately 200 staff in which we are engaged in the development of new forms of treatment for breast cancer, particularly endocrine therapy. Over the past 20 years, my group has completed the clinical development of two steroidal aromatase inhibitors, including 4-hydroxyandrostenedione and exemestane and my laboratory is currently engaged in studies aimed at understanding the role of estrogen receptor a and estrogen receptor ß in human breast cancer. We are engaged in developing novel methods for prediction of response to endocrine therapy and also doing research aimed at understanding the mechanisms of resistance to endocrine therapy.
Models
Methods
List of transgenic and KO
mice available
No
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Last update
Monday, August 25, 2008
 
Last name DALE
First name TREVOR
Institution Cardiff University
Country
Phone +44 29 2087 4652
E-mail daletc@cardiff.ac.uk
Website http://www.cardiff.ac.uk/biosi/contactsandpeople/stafflist/a-d/dale-tr...
Group leader since (year) 1992
Research interests Wnt signalling, stem cells, drug discovery, biochemistry of Wnt signalling protein complexes, signalling pathway networks.
Models gene targetted mice (knock-out and transgenic) for components of the Wnt pathway. GFP and luciferase reporter readouts for Wnt pathway activity.
Methods ES cell technologies, fat pad transplantation, protein biochemistry, high content screening
List of transgenic and KO
mice available
Yes
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Yes
Last update
Monday, May 24, 2010
 
Last name DERKSEN
First name PATRICK
Institution University Medical Center Utrecht / Medical Oncology / Lab. of Experimental Oncology
Country
Phone +31 88 75 68068
E-mail p.w.b.derksen@umcutrecht.nl
Website http://www.umcutrecht.nl/subsite/oncology/Research-groups/Derksen
Group leader since (year) 2007
Research interests Mouse Models; Mammary gland development and cancer; Metastasis
Models Human ILC and IDC cell lines; Conditional Mouse Models of ILC
Methods Orthotopic transplantations; lentiviral transductions; In vivo imaging
List of transgenic and KO
mice available
No
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Yes
Last update
Tuesday, December 01, 2009
 
Last name DEVILEE
First name PETER
Institution Leiden University Medical Center
Country
Phone +31 71 526 9510
E-mail p.devilee@lumc.nl
Website http://www.lumc.nl
Group leader since (year) 1992
Research interests Breast cancer susceptibility, somatic genetics, aneuploidy, loss of heterozygosity, genetical genomics
Models Brca1 conditional KO, human breast cancer families, breast cancer populations
Methods SNP genotyping, large scale sequencing, gene expression analysis
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name DI FIORE
First name PIER PAOLO
Institution FIRC Institute of Molecular Oncology (IFOM) Foundation, Via Adamello 16, Milano, Italy
Country
Phone +39 02 574303257
E-mail pierpaolo.difiore@ifom-ieo-campus.it
Website http://www.ifom-ieo-campus.it/
Group leader since (year) 1987
Research interests 1. Transformation by growth factor and growth factor receptor molecules as a tool to study the normal pathways regulating cell growth and their alteration in the neoplastic process. 2. Mechanisms of mitogenic signal transduction and attenuation by growth factor receptors under normal and neoplastic conditions. 3. Breast stem cell biology
Models
Methods DNA microarrays, tissue microarrays, primary cell culture, 3D breast cell culture, protein biochemistry,
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name DONTU
First name GABRIELA
Institution King's College iLondon
Country UNITED KINGDOM
Phone 44(0)2071883027
E-mail gabriela.dontu@kcl.ac.uk
Website
Group leader since (year) 2009
Research interests mammary stem cells normal breast development breast cancer stem cells
Models
Methods
List of transgenic and KO
mice available
No
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Last update
Wednesday, May 13, 2009
 
Last name EDWARDS
First name PAUL
Institution Department of Pathology and Hutchison-MRC Research Institute, University of Cambridge
Country
Phone +44 1223 763338
E-mail pawe1@cam.ac.uk
Website http://www.path.cam.ac.uk/pages/edwards/
Group leader since (year) 1977
Research interests Genomics of breast cancer, particularly chromosome translocations. Currently (2007) engaged in comprehensive analysis of translocation breakpoints in breast cancer cell lines, collecting fusion genes. Previous interest was development of normal and neoplastic mammary gland, particularly using genetic manipulation of gland by transplantation.
Models
Methods
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, December 21, 2009
 
Last name FERBY
First name INGVAR
Institution University College London (UCL)
Country
Phone +44 (0)20 7679 6293
E-mail i.ferby@ucl.ac.uk
Website http://www.ucl.ac.uk/wibr/research/cancer/if
Group leader since (year) 2006
Research interests Spatiotemporal control of ErbB receptor signalling in mammary gland development and carcinogenesis
Models Knockout and transgenic mouse models.
Methods General molecular cell biology, protein biochemistry and primary cell culture.
List of transgenic and KO
mice available
No
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Last update
Monday, September 29, 2008
 
Last name FLINT
First name DAVID
Institution Strathclyde University
Country
Phone +44 141 548 2693
E-mail david.flint@strath.ac.uk
Website http://www.strath.ac.uk
Group leader since (year) 20+
Research interests insulin-like growth factors, EMT
Models 3D co-culture approaches
Methods
List of transgenic and KO
mice available
No
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Last update
Monday, August 25, 2008
 
Last name GALLAGHER
First name WILLIAM
Institution UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Country
Phone +353-1-7166743
E-mail william.gallagher@ucd.ie
Website http://www.ucd.ie/conway/cv_188.html
Group leader since (year) 1999
Research interests (1) Systematic approaches to cancer biology, (2) Molecular basis of tumour progression, particularly metastasis, (3) Cancer biomarker discovery/validation, (4) Breast cancer and melanoma
Models Isogenic cell culture models, in vivo models, particularly xenograft (syngenic/orthotopic)
Methods Transcriptomics, proteomics, tissue microarrays, RNA interference, lentiviral transduction, non-invasive in vivo imaging (bioluminescence/biofluorescence, PET/CT)
List of transgenic and KO
mice available
No
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Last update
Monday, September 29, 2008
 
Last name GEE
First name JULIA
Institution Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, UK
Country
Phone +44 29 20875226
E-mail gee@cardiff.ac.uk
Website http://www.cf.ac.uk/phrmy/researchcentres/Tenovus/index.html
Group leader since (year) 2000
Research interests Historically the Tenovus Centre for Cancer Research has undertaken research in the area of anti-hormone and anti-growth factor resistance in breast cancer through signal transduction/pharmacological challenge studies. Our current Tenovus-funded main programme is exploring very early anti-hormone-induced signal transduction that limits initial response and promotes cell survival permitting evolution of resistance. Such drug-induced compensatory signalling also promotes further features of progression (e.g. invasion) under particular cellular contexts. A pervading goal in our studies is to reveal new therapeutic targets to subvert resistance/progression and improve response, as well as providing new markers of therapeutic response & prognosis.
Models In house panel of in vitro models derived from MCF-7 and T47D reflective of acquired resistance to various antihormones and erbB inhbitors. Our collaborations are also utilising these models in 2D/3D cell culture.
Methods Cell culture and signal transduction methodologies (including Western Blotting/PCR/reporter assays, pharmacological/antibody challenge) are core for candidate pathway studies as applied to our breast cancer models. My own areas of expertise lie in immunocytochemistry, notably using phosphospecific antibodies and their application to clinical material. I have also recently coordinated Affymetrix microarray studies as applied to our panel of cell lines that are revealing novel signalling elements induced during early drug treatment or elevated in established resistance. The relevance of these changes is subsequently being explored through functional studies, including employing SiRNA knockdown.
List of transgenic and KO
mice available
No
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Last update
Monday, September 29, 2008
 
Last name GLUKHOVA
First name MARINA
Institution UMR 144 CNRS-Institut Curie, Institut Curie, Centre de Recherche
Country
Phone +33 1 42 34 63 31
E-mail Marina.Glukhova@curie.fr
Website http://www.curie.fr/equipe/327
Group leader since (year) 1995
Research interests Cell-extracellular matrix interactions mediated by integrins in mammary development Wnt/ß-catenin signaling pathway in mammary tumorigenesis Stem/progenitor cells in the adult mouse mammary epithelium
Models Transgenic mice, mouse models of human breast tumors, primary culture of mammary cells, mouse mammary cell lines
Methods Isolation of mouse mammary epithelial cells, 2-D and 3-D cultures, transplantation into the cleared mammary fat pad, FACS, microarrays
List of transgenic and KO
mice available
No
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Monday, September 29, 2008
 
Last name GOMPEL
First name ANNE
Institution INSERM UMRS 938 Saint Antoine, Paris Paris Descartes University
Country FRANCE
Phone 0033149284692/0033142348768
E-mail anne.gompel@htd.aphp.fr
Website
Group leader since (year)
Research interests human normal breast cells hormonedependency
Models primary cultures of normal human cells xenografts of normal tissues in nude mice biopsies
Methods QPCR, IHC, Western blots, si
List of transgenic and KO
mice available
No
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Last update
Thursday, June 10, 2010
 
Last name GONZALEZ SUAREZ
First name EVA
Institution Catalan Institute of Oncology (ICO) Cancer Epigenetics and Biology Program (PEBC)
Country
Phone 34 932607500 Ext 3166
E-mail egsuarez@iconcologia.net
Website http://www.pebc.cat/grupodetalle.php?idg=15
Group leader since (year) 2007
Research interests Breast cancer and bone metastasis. RANK signaling. Tumor initiating cells. Mechanisms of resistance to current treatments. Inflammation and cancer.
Models 3D cultures, suspension cultures, primary cell cultures, orthotopic transplants of human and mouse tumors, transgenic and KO mouse models
Methods
List of transgenic and KO
mice available
No
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Yes
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Monday, September 29, 2008
 
Last name GRONER
First name BERND
Institution Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Str. 42, D-60596 Frankfurt am Main, Germany
Country
Phone +49 69 63395180
E-mail groner@em.uni-frankfurt.de
Website http://www.georg-speyer-haus.de
Group leader since (year) 1982
Research interests mammary gland biology, breast cancer, experimental therapeutics, cytokine signaling
Models mammary gland reconstitution, genetically modified mammary stem cells, in vitro differentiation
Methods cleared fat pad transplantation, lentiviral mediated transgenesis
List of transgenic and KO
mice available
No
Comments
(including wish list)
great initiative
Mailing list
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Yes
Last update
Monday, September 29, 2008
 
Last name HILKENS
First name JOHN
Institution Netherlands Cancer Institute
Country
Phone +31 20 512 2018
E-mail j.hilkens@nki.nl
Website http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Ge...
Group leader since (year) 1982
Research interests The aim of my laboratory is to identify and study novel genes involved in breast cancer and unravel the collaborating genetic pathways leading to breast cancer and breast cancer progression using mouse mammary tumor virus (MMTV) induced insertional mutagenesis in mouse models. genes of interest: R-spondin genes, Irs genes and membrane associated mucins (MUC1)
Models various mouse models including K14-cre; p53f/f and MMTV cNeu transgenics
Methods High throughput in vivo MMTV mediated insertional mutagenesis screens, protein biochemistry, retroviral transduction, in vivo tumorigeneicity and metastasis assay's
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name HOPKINS
First name ANN
Institution Royal College of Surgeons in Ireland
Country IRELAND
Phone +35318093858
E-mail annhopkins@rcsi.ie
Website http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=253&pip=team#...
Group leader since (year) 2005
Research interests - Altered cell-cell and cell-matrix adhesion in breast cancer progression; - The role of junction adhesion molecule-A (JAM-A) in breast cancer invasion; - Lipid rafts as modulators of cell migration; - Breast progenitor cells
Models Primary cultures of human breast tumours Tissue microarrays 3-dimensional cell culture models
Methods Protein biochemistry Confocal microscopy Functional assays relevant to cell motility
List of transgenic and KO
mice available
No
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Last update
Thursday, November 05, 2009
 
Last name HOWARD
First name BEATRICE
Institution Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London
Country
Phone + 44 (0) 207 153 5177
E-mail beatrice.howard@icr.ac.uk
Website http://www.breakthroughcentre.org.uk/research_groups/gene_function/bre...
Group leader since (year)
Research interests mammary morphogenetic events with relevance to breast cancer etiology: Neuregulin3 (Nrg3) and Erbb4 signalling, embryonic mammary gland development, mammary lineage commitment and differentiation
Models knockout and transgenic mice, ex vivo culture
Methods general molecular, cellular and developmental biology techniques, qPCR, IF, ISH, protein analysis, microdissection, etc.
List of transgenic and KO
mice available
No
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Last update
Monday, August 25, 2008
 
Last name HYNES
First name NANCY
Institution Friedrich Miescher Institute for Biomedical Research
Country
Phone 41 61 697 8107
E-mail hynes@fmi.ch
Website http://www.fmi.ch/hynes.n
Group leader since (year) 1981
Research interests Breast cancer, ErbB family of receptor tyrosine kinases, mammary gland development, FGFRs, Wnt pathway, cell migration,
Models Transgenic mammary tumor models, 4T1 mammary cancer model, human tumor xenograft models. mouse premature aging model
Methods Protein analysis, migration, FACs, animal cancer models, etc
List of transgenic and KO
mice available
No
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Yes
Last update
Monday, September 29, 2008
 
Last name IGGO
First name RICHARD
Institution Bergonie Cancer Institute, University of Bordeaux
Country
Phone 00 33 5 56 33 04 23
E-mail richard.iggo@me.com
Website http://www.bergonie.org/fr/basic-research/richard-iggo.html
Group leader since (year) 1991
Research interests Prediction of response to chemotherapy using gene signatures. Role of p53 in breast cancer. Quantitative transformation of normal mammary epithelial cells.
Models Orthotopic xenografts in NOD/SCID mouse mammary glands.
Methods Lentiviral infection of HMECs and BPECs to express oncogenes and inactivate tumour suppressor genes. Affymetrix expression and SNP chips from clinical samples.
List of transgenic and KO
mice available
No
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Yes
Last update
Tuesday, December 08, 2009
 
Last name JONKERS
First name JOS
Institution Netherlands Cancer Institute
Country
Phone +31-20-5122000
E-mail j.jonkers@nki.nl
Website http://research.nki.nl/molbio/Groups/jonkers/jonkersgroup.htm
Group leader since (year) 2003
Research interests BRCA1- and BRCA2-associated breast cancer, E-cadherin-mutated lobular breast cancer, inflammation and cancer, cancer stem cells, targeted anticancer therapeutics
Models Conditional knockout and transgenic mice, in vitro cultures, orthotopic grafting models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
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Yes
Last update
Monday, September 29, 2008
 
Last name KAENEL
First name PHILIP
Institution Department for Clinical Research University of Bern
Country SWITZERLAND
Phone
E-mail philip.kaenel@dkf.unibe.ch
Website
Group leader since (year)
Research interests Ephrin-B2 and EphB4 in mammary gland development
Models
Methods Flow cytometry, in vivo assays, in vitro colony-forming and mammopshere assays, confocal microscopy
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
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No
Last update
Friday, June 18, 2010
 
Last name KRESS
First name CLEMENCE
Institution Institut National de la Recherche Agronomique (INRA)
Country
Phone +33 (0) 1 34 65 25 54
E-mail Clemence.Kress@jouy.inra.fr
Website http://w3.jouy.inra.fr/unites/gpl/index.shtml
Group leader since (year)
Research interests The unit works on genomics and physiology of lactation: hormonal signalisation, gene expression control, synthesis of milk components, membrane traffic, endo/exocytosis pathways.
Models Rabbit, cattle and mouse mammary gland tissue.
Methods Cryosections of mammary tissue for DNA, RNA FISH, IF. Preservation of nuclear structure, confocal microscopy, 3D reconstitution and modelling
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
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Yes
Last update
Monday, August 25, 2008
 
Last name OREND
First name GERTRAUD
Institution INSERM U682, De l`homéostasie tissulaire au cancer et à l`inflammation Equipe: Impact du microenvironnement sur l`angiogenèse et l`invasion tumorale
Country FRANCE
Phone 33 (0)3 88 27 53 55
E-mail gertraud.orend@inserm.u-strasbg.fr
Website http://u682-inserm.u-strasbg.fr
Group leader since (year) 2002
Research interests Extracellular matrix in tissue homeostasis, inflammation, angiogenesis, metastasis, stem cells, tenascin-C, laminins
Models 3D cultures, ex vivo culture models (HMECs...), transgenic and KO tenascin-C and laminin-111 mice
Methods cell culture assays, BiAcore, biochemistry (western blot, IP, QPCR..), tissue analysis
List of transgenic and KO
mice available
No
Comments
(including wish list)
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Yes
Last update
Thursday, November 19, 2009
 
Last name ORIAN-ROUSSEAU
First name VÉRONIQUE
Institution Karlsruhe Institute of Technology, Institute for Toxicology and Genetics
Country
Phone +497247826523
E-mail veronique.orian-rousseau@kit.edu
Website http://itgmv1.fzk.de/itg/orian-rousseau/orian-rousseau.html
Group leader since (year) 2003
Research interests Molecular mechanisms involved in tumor progression, Receptor Tyrosine Kinases (EGFR, c-Met, VEGFR..) activation and internalisation, Cell Adhesion Molecules (in particular CD44, ICAM), Role of CD44 in Breast Cancer Stem cells, Signal Transduction
Models CD44 knock out, Xenograft, pancreas orthotopic models
Methods KO technology, Transgenic, Angiogenesis assays,
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
CD44 floxed mice
Mailing list
(managed by webmaster)
Yes
Last update
Wednesday, December 02, 2009
 
Last name PAGES
First name GILLES
Institution University of Nice Sophia Antipolis UMR CNRS 6543
Country
Phone 00 33 4 92 03 12 31
E-mail gpages@unice.fr
Website
Group leader since (year) 1999
Research interests Normal and tumor angiogenesis. We are looking at the regulation of angiogenic factor VEGf and IL-8 in particular at the post transcriptional level. We are studying mRNA binding protein that destabilizes the mRNA. We are looking at the loss of mRNA degradative protein in breast cancer on tumor cell lines and on tumor samples. We are also looking at the effect of targetted therapy on the expression of these proteins
Models Cell with different metastatic potential with inducible expression of mRNA degradative protein, tumor samples
Methods Stable and transient transfection of genes of interest. In vivo imaging of tumor xenografts of cells with expression of luciferase. Determination of angiogenic factor by ELISA; Reporter genes (promoters and 3'UTR)
List of transgenic and KO
mice available
No
Comments
(including wish list)
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No
Last update
Monday, September 29, 2008
 
Last name PELICCI
First name PIER GIUSEPPE
Institution Experimental Oncology European Institute of Oncology and the Campus IFOM-IEO
Country
Phone 0039-02-57489831
E-mail piergiuseppe.pelicci@ifom-ieo-campus.it
Website http://www.ifom-ieo-campus.it/
Group leader since (year) 1987
Research interests 1.Hematopoietic stem cells and Acute Myeloid Leukemias 2. Breast stem cells and breast cancer 3.Effects of checkpoint activation on tissue homeostasis and molecular mechanisms of aging 4. Epigenetics and environmental cancer risk assessment
Models Mammospheres; KO and transgenic mice, humanized mouse, conditional and constitutive models
Methods Cell culture (primary cell culture; cell lines) and mouse models; 3D cultures; xenografts; standard molecular and cell biology techniques; time-lapse microscopy; FACS sorting; siRNA technology; DNA microarrays, tissue microarrays; ChIP, ChIP-chip and ChIP-Seq.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Thursday, December 17, 2009
 
Last name RIETHDORF
First name SABINE
Institution Institute of Tumor Biology, University Medical center Hamburg-Eppendorf, Germany
Country
Phone 0049-40-42803-2628
E-mail s.riethdorf@uke.uni-hamburg.de
Website http://www.uke.uni-hamburg.de/institute/tumorbiologie
Group leader since (year) >10
Research interests Disseminated and circulating tumor cells in bone marrow and blood, molecular and phenotypical characterization of DTC, CTC, breast cancer, stem cells
Models
Methods Enrichment, detection and characterization of DTC, CTC, automatic detection systems, in situ hybridization (DNA; RNA)
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, August 25, 2008
 
Last name RIO
First name MARIE-CHRISTINE
Institution Institut de Génétique et de Biologie Moléculaire et Cellulaire
Country
Phone 0388653424
E-mail rio@igbmc.u-strasbg.fr
Website
Group leader since (year) 1989
Research interests Molecular biology of breast cancers. Normal and pathological function of few genes: pS2/TFF1, ST3/MMP11, MLN64, MLN51 and TRAF4, all cloned in the laboratory. Proteomic of breast cancers
Models Knock-out mice for the genes cited above. Several models of tumorigenesis in mice
Methods Cellular and molecular biology Transgenic mice
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name ROTTENBERG
First name SVEN
Institution The Netherlands Cancer Institute
Country
Phone +31 20 5122082
E-mail s.rottenberg@nki.nl
Website
Group leader since (year)
Research interests mouse models for anti-cancer drug resistance
Models K14-cre, Brca1F/F, p53F/F Ref.: Liu et al., PNAS 104, 12111-12116, 2007 Rottenberg et al., PNAS 104, 12117-22, 2007
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, August 25, 2008
 
Last name SCHMITT
First name FERNANDO
Institution IPATIMUP, Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias, s/n4200-465 PortoPortugalRua Dr. Roberto Frias, s/n
Country
Phone +351-225570700
E-mail fernando.schmitt@ipatimup.pt
Website http://www.ipatimup.pt
Group leader since (year) 1995
Research interests Breast cancer pathology; basal-like carcinomas; basal cell markers; breast cancer stem cells; P-cadehrin role in breast carcinogenesis: regulation and function; HER-2/EGFR-targeted therapy resistance; vitamin D effect in controlling breast cancer; PTEN role in breast cancer
Models In vitro cell culture; breast cancer tissue series; tissue microarrays (TMAs); mice xenografts
Methods Microscopy; immunohisto/cytochemistry; cell culture; western-blot; immunoprecipitation; siRNA technology; real-time PCR; cell invasion and aggregation assays; time-lapse microscopy; proteomics; cDNA cloning; luciferase-reporter assays
List of transgenic and KO
mice available
No
Comments
(including wish list)
None
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name SCHULER
First name LINDA
Institution University of Wisconsin--Madison
Country UNITED STATES
Phone 001-608-263-9825
E-mail schulerl@svm.vetmed.wisc.edu
Website
Group leader since (year) long time
Research interests hormonal contributions (especially prolactin) to the development, progression and therapeutic responsiveness of breast cancer
Models human breast cancer cell lines, NRL-PRL transgenic mouse model
Methods in vitro and in vivo
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
No
Last update
Monday, July 12, 2010
 
Last name SIERRA
First name ANGELS
Institution IDIBELL
Country
Phone 34 93 2607429
E-mail asierra@idibell.org
Website http://www.idibell.org/
Group leader since (year) 1997
Research interests Apoptotis, Breast cancer, Diagnostic markers, Metastasis pathogenesis, New diagnostic tools
Models Metastatic variants from human breast carcinomas, Brain and lung metastasis models in nude mice, Primary cultures of metastatic cells
Methods Bioinformatics, Cell biology, IHC, Proteomics, Tissue array
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name SLEEMAN
First name JONATHAN
Institution University of Heidelberg, Medical Faculty Mannheim, Ludolf-Krehl-Str 13-17, 68167 Mannheim, Germany and Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, 76021 Karlsruhe, Germany
Country
Phone +49 621 383 9955
E-mail sleeman@medma.uni-heidelberg.de
Website http://www.ma.uni-heidelberg.de/inst/cbtm/mbio/
Group leader since (year) 1997
Research interests Tumor metastasis, particularly the role of the lymphatic system in tumor dissemination, the role of cancer stem cells in metastasis and the microenvironment that supports metastatic growth
Models Knockout and transgenic mice, transplantable syngeneic and xenograft tumor models, in vitro cell models
Methods Animal technology, standard immunohistochemistry, molecular and cell biology techniques, primary cell culture, FACS sorting, microarray, in vitro metastasis assays, time lapse, cell encapsulation, synthetic organic chemistry, various immunoassays, yeast 2 hybrid, confocal, whole mounts, etc
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name SMALLEY
First name MATT
Institution Breakthrough Breast Cancer Research Centre, Institute of Cancer Research
Country
Phone +44 (0)207 153 5546
E-mail matthew.smalley@icr.ac.uk
Website http://www.breakthroughcentre.org.uk/research_groups/mammary_stem_cell...
Group leader since (year) 2006
Research interests Stem cells in normal and neoplastic mammary epithelium; control of self-renewal and differentiation in mammary stem cells
Models In vivo mouse mammary gland
Methods Harvest of primary mouse mammary epithelium; multicolour flow cytomtery; cleared fat pad transplantation; qPCR
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name SMITH
First name GILBERT
Institution National Cancer Institute
Country UNITED STATES
Phone 1-0-301-496-2385
E-mail gs4d@nih.gov
Website
Group leader since (year)
Research interests Mammary gland development, stem cell hierarchy in epithelium, growth senescence, cancer, mutations relevant to mammary epithelial transformation
Models CzechII mice (no MMTV provirus in genome); WAPCre/Rosa26flox-STOP-flox-lacZ model, reprogramming non-mammary cells in mouse mammary glands during outgrowth
Methods Tissue culture Transplantation Microscopy
List of transgenic and KO
mice available
No
Comments
(including wish list)
Not in Europe but happy to connect and collaborate/consult with members of this group...
Mailing list
(managed by webmaster)
Yes
Last update
Monday, June 21, 2010
 
Last name SONNENBERG
First name ARNOUD
Institution The Netherlands Cancer Inst.
Country
Phone 31-20-5121942
E-mail a.sonnenberg@nki.nl
Website
Group leader since (year) 1990
Research interests Role of laminin-binding integrins and associated proteins in mammary gland development, mammary differentiation and tumorigenesis. Hemidesmosomes, integrin signaling, diagnostic markers for mammary gland development and stem cells in normal and neoplastic epithelium
Models Conditional knockout mice for the integrin alpha3 (Iga3), beta4 (Itgb4) and the tetraspanin CD151.
Methods Microscopy, immunohistochemistry, cell culture, protein biochemistry, KO and transgenic mice, etc.
List of transgenic and KO
mice available
No
Comments
(including wish list)
None
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name STEIN
First name TORSTEN
Institution Division of Cancer Sciences and Molecular Pathology, University of Glasgow
Country
Phone +44 (0)141 211 1942
E-mail T.Stein@clinmed.gla.ac.uk
Website http://www.gla.ac.uk/departments/cancersciences/pathologyandgeneregula...
Group leader since (year) 2006
Research interests mammary gland development; involution; terminal end buds; breast cancer development. We are trying to identify and characterise novel pathways that are involved or control key stages of mammary gland development, and that may be deregulated in breast cancer. Particular genes of interest: Annexin A8, Reelin, TSC-22.
Models normal mouse; TSC-22D1i2 transgenic mice
Methods microarrays, IF, IHC, standard cell and molecular biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
none
Mailing list
(managed by webmaster)
Yes
Last update
Tuesday, December 01, 2009
 
Last name STINGL
First name JOHN
Institution Cancer Research UK Cambridge Research Institute
Country UNITED KINGDOM
Phone 44 1223 404 353
E-mail john.stingl@cancer.org.uk
Website http://www.cambridgecancer.org.uk/research/loc/cambridge/ccri/stinglj/...
Group leader since (year) 2008
Research interests Mouse and human mammary gland stem cells. Basal-like breast cancer. Mechanisms of resistance to anti-estrogen therapies
Models
Methods In vivo mammary stem cell assays. In vitro colony forming assays. Flow cytometry
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Tuesday, March 03, 2009
 
Last name STREULI
First name CHARLES
Institution University of Manchester
Country
Phone +44 161 27 5626
E-mail cstreuli@manchester.ac.uk
Website http://www.breastcentre.manchester.ac.uk/
Group leader since (year) 1991
Research interests normal mammary gland development and function; integrins and integrin signalling; extracellular matrix; apoptosis; inhibitor-of-apoptosis-proteins; early breast cancer
Models primary mammary cell cultures; mammary-specific gene deletion in vivo and culture
Methods primary cell culture; 3D culture; 3D immunstaining; gene deletion in vivo with mammary-specific Cre; gene deletion in primary culture with 4-OHT (CreER) or viral infection with adenoCre; apoptosis methods; siRNA oligos, shRNA vectors and shRNA lentiviruses
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name VAN DE WATER
First name BOB
Institution Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
Country
Phone 31 71-5276223
E-mail b.water@lacdr.leidenuniv.nl
Website
Group leader since (year) 1999
Research interests Role of cell-ECM signaling in mammary gland development and breast cancer development and progression/metastasis. Integrated signaling between receptor protein tyrosine kinase and focal adhesion kinase (FAK). FAK-mediated signaling.
Models Conditional knockouts for FAK and p53. Mammary gland reconstitution models. Orthotopic breast tumor/metastasis models. 2D and 3D migration/invasion models. 3D branching morphogenesis models. Models for focal adhesion dynamics.
Methods siRNA and shRNA libraries. Retro- and lenti-viral transduction of MMEC and breast tumor cell lines. 2D and 3D MEC cultures. Live cell imaging (spectral imaging, TIRF microscopy, confocal, DIC) followed by quantitative image analysis. Fluorescence and bioluminescence analysis of breast cancer progression. Conditional expression of DN and DA target genes in orthotopic breast tumor models. Intravital imaging of breast tumor cell migration in primary tumor. Gene expression profilling.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
No
Last update
Monday, September 29, 2008
 
Last name VAN LOHUIZEN
First name MAARTEN
Institution The Netherlands Cancer Institute
Country
Phone +31-20-5122030
E-mail m.v.lohuizen@nki.nl
Website http://research.nki.nl/lohuizenlab/
Group leader since (year) 1995
Research interests We study epigenetic gene regulation and transcriptional repression by Polycomb-group (Pc-G) protein complexes, and the effects of deregulation of Pc-G genes on development, Cell cycle control, cancer formation and stem cell maintenance. In addition, we are performing large-scale genetic screens in primary cells and in cancer-predisposed mice to identify cancer-relevant combinations of collaborating oncogenes and tumor-suppressor genes.
Models Diverse animal models: Bmi1 KO and conditional KO mice; EZH2 conditional KO mice, RNF2 conditional KO mice;Tissue-specific inducible Bmi1 transgenic mice;MMTV-Wnt1; MMTV-NEU; MMTV-Myc;
Methods mouse and human ES cell technologies, fat pad transplantation, 2D MEC culture, protein biochemistry, high content screening, lentiviral or retroviral transduction, stem cell FACS sorting, DAMid chromatin profiling, High throughput in vivo retroviral insertional mutagenesis screens
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name VAN RHEENEN
First name JACCO
Institution Hubrecht Institute
Country NETHERLANDS
Phone +31 (0)30-2121905
E-mail j.vanrheenen@hubrecht.eu
Website http://www.niob.knaw.nl/research/vanrheenen/index.html
Group leader since (year) 2008
Research interests Complication of metastasis, the process in which cells detach from the primary tumor to form new distant tumor sites, is the primary reason why women die from breast cancer. The metastatic behavior of tumor cells is highly dependent on the cell’s intrinsic characteristics and on the tumor microenvironment, such as stromal cells and the extracellular matrix. We study both by combining conditional mouse models that recapitulate human breast tumors and intravital imaging techniques (high resolution imaging of metastasis in living animals in real time). By these experiments we hope to indentify new drug targets that combined with current clinical approaches may lead to new therapies.
Models allograft tumor models:1) Ola/FVB mice with Kep1_11 cells (Cdh-/-;Trp53-/-, Derksen et al, Canc Cell 2004)2) BalbC with 4T1 cell line. Genetic model:MMTV-Neu tumor model
Methods Our lab studies the behavior of metastasizing tumor cells inside living mice by intravital imaging; the imaging of living tissue. Whole mice bearing metastasizing tumors are imaged at subcellular resolution by confocal or two-photon microscopy. Our lab, together with the labs of Drs Segall and Condeelis (Albert Einstein College of Medicine, Bronx, NY, USA) has developed a mammary gland imaging window in order to image and track cells for multiple days inside mammary tumors in living mice. Moreover, we use intravital FRET imaging to study activity of several signaling pathways inside metastasizing tumor cells.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
No
Last update
Monday, January 11, 2010
 
Last name VANHAESEBROECK
First name BART
Institution Centre for Cell Signalling - Institute of Cancer - Barts and the London Medical School -
Country
Phone 00-44-207-882-8201
E-mail bart.vanh@qmul.ac.uk
Website http://www.cancer.qmul.ac.uk/research/cell_signalling/
Group leader since (year) 1998
Research interests Signal transduction - cancer and inflammation
Models mouse models - knock-in gene-targeting - PI 3-kinase and related pathways
Methods standard cell and molecular biology - biochemistry - mass spectrometry
List of transgenic and KO
mice available
No
Comments
(including wish list)
special interest in cancer and inflammation, in relation to breast cancer
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name VELTMAAT
First name JACQUELINE
Institution A*STAR Institute of Molecular and Cell Biology
Country SINGAPORE
Phone +65 6586 9618
E-mail jmveltmaat@imcb.a-star.edu.sg
Website http://www.imcb.a-star.edu.sg/php/jv.php
Group leader since (year) 2006
Research interests - molecular regulation of embryonic phase of mammary gland development (in particular induction) as well as postnatal morphogenesis and differentiation - creation of software for image analysis
Models mouse mutants
Methods histology, RNA-RNA in situ hybridization and immunochemistry on whole mount and sectioned embryos, tissue separation and recombination, organ culture, transplantation, micro-array
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Thursday, July 08, 2010
 
Last name VENEZIANI
First name BIANCA MARIA
Institution Dipartimento di Biologia e Patologia Cellulare e Molecolare Facoltà di Medicina e Chirurgia Università di Napoli "Federico II"
Country ITALY
Phone 390817463758
E-mail bianca.veneziani@unina.it
Website http://www.dbpcm.org/cms/
Group leader since (year) 2000
Research interests Human breast cancer, steroid receptors, signalling and stem cells. Mechanisms of resistance to current treatments. Stromal and adipose tissue of the mammary gland.
Models Breast cancer epithelial-stromal co-cultures, mammospheres.
Methods Primary cell culture, breast cancer cell lines, in vitro analysis of the tumor-stroma interaction, cryopreservation, qPCR, FACS, stem cell sorting, RNA and protein analyses.
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Friday, January 29, 2010
 
Last name VIVANCO
First name MARIA
Institution CIC bioGUNE, Cell Biology and Stem Cells Unit, Bilbao, Spain
Country
Phone +34 94 406 1322
E-mail mdmvivanco@cicbiogune.es
Website http://www.cicbiogune.es/
Group leader since (year) 1997
Research interests Steroid hormone receptors, human mammary gland, breast cancer, stem cells, regulation of self-renewal and differentiation in human breast stem cells
Models human mammary epithelial cells
Methods 2D and 3D cultures, FACS, qPCR, multiplex RT-PCR, general molecular and cellular biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name WATSON
First name CHRISTINE
Institution University of cambridge
Country
Phone +44 1223 333725
E-mail cjw53@cam.ac.uk
Website http://www.path.cam.ac.uk~madgroup
Group leader since (year)
Research interests
Models
Methods
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, June 07, 2010
 
Last name WHITELAW
First name BRUCE
Institution Roslin Institute and Royal (Dick) School of Veterinary Studies Univeristy fo Edinburgh Roslin Midlothian EH25 9PS, UK
Country
Phone +44-(0)131-527-4200
E-mail bruce.whitelaw@rolsin.ed.ac.uk
Website
Group leader since (year) 1994
Research interests gene transfer gene expression systems cancer stem cell biology mammary growth and development
Models transgenic mice transgenic sheep and pigs
Methods general molecular biology
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Monday, September 29, 2008
 
Last name WIESMÜLLER
First name LISA
Institution Gynaecological Oncology, Head Department of Obstetrics and Gynaecology of the University of Ulm
Country GERMANY
Phone +49-(0)731-500-58800/58801
E-mail lisa.wiesmueller@uni-ulm.de
Website http://www.uni-ulm.de/klinik/ufk/cms/html/forschung_gyn-onko.htm
Group leader since (year) 2001
Research interests apoptosis breast cancer risk chemoprevention DNA double strand break repair homologous recombination replication fork stalling prediction of therapeutic responsiveness
Models - patient cell lines - peripheral lymphocytes, fibroblasts, and primary epithelial cells from mammary gland of probands/patients - MEFs from mice differing in breast cancer susceptibilities
Methods - analysis of distinct DNA double strand repair pathways - nuclear foci analysis for DNA damage/repair factors - apoptosis analyses - characterization of genotoxic, chemopreventive, and therapeutic agents agents
List of transgenic and KO
mice available
No
Comments
(including wish list)
Mailing list
(managed by webmaster)
No
Last update
Monday, September 07, 2009
 
Last name YOUNG
First name LEONIE
Institution Royal College of Surgeons in Ireland
Country IRELAND
Phone +35314028576
E-mail lyoung@rcsi.ie
Website http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=35&pip=pubs#t...
Group leader since (year) 2001
Research interests - Coactivator proteins in endocrine-resistant breast cancer - Identification of biomarkers to predict endocrine-sensitivity and endocrine-resistance in breast cancer patients
Models Breast cancer patient primary cultures Tissue microarrays Murine tumour models
Methods Immunohistochemistry In situ FRET CHIP-Seq Transcription factor binding
List of transgenic and KO
mice available
Yes
Comments
(including wish list)
Mailing list
(managed by webmaster)
Yes
Last update
Thursday, November 05, 2009